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Current Atherosclerosis Reports
Published in: Current Atherosclerosis Reports 3/2011

01-06-2011

Genetics of Redox Systems and Their Relationship with Cardiovascular Disease

Authors: Dan Farbstein, Yitzchak Z. Soloveichik, Nina S. Levy, Andrew P. Levy

Published in: Current Atherosclerosis Reports | Issue 3/2011

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Abstract

As atherosclerosis is still one of the major causes of death in Western populations, it is important to identify those individuals who are at increased risk for the disease so that aggressive treatment may be administered as early as possible. Following the understanding that oxidative stress has a pivotal role in the development and progression of atherosclerosis, many polymorphisms in genes that are related to redox systems were examined for their association with increased risk for cardiovascular disease (CVD). Although many polymorphisms were studied, only a handful showed consistent relevance to CVD in different trials. This article focuses on six of these polymorphisms, examining their effect on the risk for CVD as well as their effect on protein expression and function. Reports regarding pharmacogenetic implications of these polymorphisms, where such exist, are discussed as well.
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Metadata
Title
Genetics of Redox Systems and Their Relationship with Cardiovascular Disease
Authors
Dan Farbstein
Yitzchak Z. Soloveichik
Nina S. Levy
Andrew P. Levy
Publication date
01-06-2011
Publisher
Current Science Inc.
Published in
Current Atherosclerosis Reports / Issue 3/2011
Print ISSN: 1523-3804
Electronic ISSN: 1534-6242
DOI
https://doi.org/10.1007/s11883-011-0170-7

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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