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Fluids and Barriers of the CNS
Published in: Fluids and Barriers of the CNS 1/2013

Open Access 01-12-2013 | Review

Genetic mouse models to study blood–brain barrier development and function

Authors: Fabien Sohet, Richard Daneman

Published in: Fluids and Barriers of the CNS | Issue 1/2013

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Abstract

The blood–brain barrier (BBB) is a complex physiological structure formed by the blood vessels of the central nervous system (CNS) that tightly regulates the movement of substances between the blood and the neural tissue. Recently, the generation and analysis of different genetic mouse models has allowed for greater understanding of BBB development, how the barrier is regulated during health, and its response to disease. Here we discuss: 1) Genetic mouse models that have been used to study the BBB, 2) Available mouse genetic tools that can aid in the study of the BBB, and 3) Potential tools that if generated could greatly aid in our understanding of the BBB.
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Metadata
Title
Genetic mouse models to study blood–brain barrier development and function
Authors
Fabien Sohet
Richard Daneman
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Fluids and Barriers of the CNS / Issue 1/2013
Electronic ISSN: 2045-8118
DOI
https://doi.org/10.1186/2045-8118-10-3

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