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Published in: Familial Cancer 2/2013

Open Access 01-06-2013 | Original Article

Genetic modifiers of cancer risk in Lynch syndrome: a review

Authors: Bente A. Talseth-Palmer, Juul T. Wijnen, Desma M. Grice, Rodney J. Scott

Published in: Familial Cancer | Issue 2/2013

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Abstract

The report by Aldred Scott Warthin in 1913 of a cancer family history and expanded on by Henry T. Lynch demonstrated one of the most enduring traits observed in patients with Lynch syndrome. The recognition of a variety of malignancies occurring at differing ages within a single family suggested the role of genetic variance on disease expression in an autosomal dominantly inherited genetic condition. With the identification of the genetic basis of Lynch syndrome and the subsequent collection of families and their medical records it has become possible to identify subtle genetic effects that influence the age at which disease onset occurs in this cancer predisposition. Knowledge about genetic modifiers influencing disease expression has the potential to be used to personalise prophylactic screening measures to maximise the benefits for family members and their carers.
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Metadata
Title
Genetic modifiers of cancer risk in Lynch syndrome: a review
Authors
Bente A. Talseth-Palmer
Juul T. Wijnen
Desma M. Grice
Rodney J. Scott
Publication date
01-06-2013
Publisher
Springer Netherlands
Published in
Familial Cancer / Issue 2/2013
Print ISSN: 1389-9600
Electronic ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-013-9614-2

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