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01-09-2017 | Brief Report

Genetic diversity of human papillomavirus types 35, 45 and 58 in cervical cancer in Brazil

Authors: Diogo Lisbôa Basto, João Paulo Vidal, Valéria Barbosa Pontes, Shayany Pinto Felix, Laine Celestino Pinto, Bruno Moreira Soares, Luis Felipe Martins, Flávia Miranda Correa, Raquel Carvalho Montenegro, Cláudia Bessa Pereira Chaves, Liz Maria Almeida, Miguel Ângelo Martins Moreira

Published in: Archives of Virology | Issue 9/2017

Abstract

In Brazil, most studies of intra-type variants of human papillomavirus (HPV) have focused on HPV16 and HPV18, but other high-risk HPV types have not been studied. Here, we report the prevalence of lineages and variants of HPV35, HPV45 and HPV58 in cervical cancers from the Amazonian and Southeast Brazilian regions. The most frequent sublineages were A1 for HPV35, B2 for HPV45, and A2 for HPV58. The Southeast region had a higher frequency of the B2 sublineage of HPV45, and for HPV35, the genetic and nucleotide sequence diversity were higher in the Southeast region, suggesting that regional factors are influencing the diversity and lineage prevalence.

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Title: Genetic diversity of human papillomavirus types 35, 45 and 58 in cervical cancer in Brazil
Authors: Diogo Lisbôa Basto
João Paulo Vidal
Valéria Barbosa Pontes
Shayany Pinto Felix
Laine Celestino Pinto
Bruno Moreira Soares
Luis Felipe Martins
Flávia Miranda Correa
Raquel Carvalho Montenegro
Cláudia Bessa Pereira Chaves
Liz Maria Almeida
Miguel Ângelo Martins Moreira
Publication date: 01-09-2017
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 9/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-017-3439-5

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