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Virology Journal
Published in: Virology Journal 1/2011

Open Access 01-12-2011 | Short report

Genetic characterization of avian influenza subtype H4N6 and H4N9 from live bird market, Thailand

Authors: Trong Wisedchanwet, Manoosak Wongphatcharachai, Supanat Boonyapisitsopa, Napawan Bunpapong, Pravina Kitikoon, Alongkorn Amonsin

Published in: Virology Journal | Issue 1/2011

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Abstract

A one year active surveillance program for influenza A viruses among avian species in a live-bird market (LBM) in Bangkok, Thailand was conducted in 2009. Out of 970 samples collected, influenza A virus subtypes H4N6 (n = 2) and H4N9 (n = 1) were isolated from healthy Muscovy ducks. All three viruses were characterized by whole genome sequencing with subsequent phylogenetic analysis and genetic comparison. Phylogenetic analysis of all eight viral genes showed that the viruses clustered in the Eurasian lineage of influenza A viruses. Genetic analysis showed that H4N6 and H4N9 viruses display low pathogenic avian influenza characteristics. The HA cleavage site and receptor binding sites were conserved and resembled to LPAI viruses. This study is the first to report isolation of H4N6 and H4N9 viruses from birds in LBM in Thailand and shows the genetic diversity of the viruses circulating in the LBM. In addition, co-infection of H4N6 and H4N9 in the same Muscovy duck was observed.
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Metadata
Title
Genetic characterization of avian influenza subtype H4N6 and H4N9 from live bird market, Thailand
Authors
Trong Wisedchanwet
Manoosak Wongphatcharachai
Supanat Boonyapisitsopa
Napawan Bunpapong
Pravina Kitikoon
Alongkorn Amonsin
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2011
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-8-131

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