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Breast Cancer Research
Published in: Breast Cancer Research 6/2007

01-12-2007 | Commentary

Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes

Authors: Silje H Nordgard, Fredrik E Johansen, Grethe IG Alnæs, Bjørn Naume, Anne-Lise Børresen-Dale, Vessela N Kristensen

Published in: Breast Cancer Research | Issue 6/2007

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Abstract

Recently, genome-wide association studies of breast cancer revealed single nucleotide polymorphisms (SNPs) in five genes with novel association to susceptibility. While there is little doubt that the novel susceptibility markers produced from such highly powered studies are true, the mechanisms by which they cause the susceptibility remain undetermined. We have looked at the expression levels of the identified genes in tumours and found that they are highly significantly differentially expressed between the five established breast cancer subtypes. Also, a significant association between SNPs in these genes and their expression in tumours was seen as well as a significantly different frequency of the SNPs between the subtypes. This suggests that the observed genes are associated with different breast cancer subtypes, and may exert their effect through their expression in the tumours. Thus, future studies stratifying patients by their molecular subtypes may give much more power to classic case control studies, and genes of no or borderline significance may appear to be high-penetrant for certain subtypes and, therefore, be identifiable.
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Metadata
Title
Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes
Authors
Silje H Nordgard
Fredrik E Johansen
Grethe IG Alnæs
Bjørn Naume
Anne-Lise Børresen-Dale
Vessela N Kristensen
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2007
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1784

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