Tamoxifen treatment for DCIS - NSABP B-24 trial

Excerpt

The management of ductal carcinoma in situ (DCIS) has changed markedly since the mid-1980s with many cases now being treated by breast conserving treatment. The National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-17 clearly showed that lumpectomy followed by radiation therapy was more effective than lumpectomy alone in prevention of an invasive tumor in the ipsilateral breast. Tamoxifen has also been reported to prevent tumour recurrences in the ipsilateral breast and second primary tumors in the contralateral breast of women who have undergone lumpectomy and radiation therapy for primary invasive breast cancer. …