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Journal of Clinical Immunology

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01-10-2021 | Generalized Pustular Psoriasis | Letter to Editor

SARS-CoV-2 infection inducing severe flare up of Deficiency of Interleukin Thirty-six (IL-36) Receptor Antagonist (DITRA) resulting from a mutation invalidating the activating cleavage site of the IL-36 receptor antagonist

Authors: Alizée Bozonnat, Florence Assan, Jérôme LeGoff, Emmanuelle Bourrat, Hervé Bachelez

Published in: Journal of Clinical Immunology | Issue 7/2021

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To the Editor, …

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Bal E, Lim AC, Shen M, Douangpanya J, Madrange M, Gazah R, et al. Mutation in IL36RN impairs the processing and regulatory function of the interleukin-36-receptor antagonist and is associated with DITRA syndrome. Exp Dermatol. 2019;28(10):1114–7. https://doi.org/10.1111/exd.13387.CrossRefPubMed

Macleod T, Doble R, McGonagle D, Wasson CW, Alase A, Stacey M, et al. Neutrophil Elastase-mediated proteolysis activates the anti-inflammatory cytokine IL-36 Receptor antagonist. Sci Rep. 2016;6:24880. https://doi.org/10.1038/srep24880.CrossRefPubMedPubMedCentral

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Lepelley A, Martin-Niclós MJ, Le Bihan M, Marsh JA, Uggenti C, Rice GI, et al. Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling. J Exp Med. 2020;217(11):e20200600. https://doi.org/10.1084/jem.20200600.CrossRefPubMedPubMedCentral

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Title: SARS-CoV-2 infection inducing severe flare up of Deficiency of Interleukin Thirty-six (IL-36) Receptor Antagonist (DITRA) resulting from a mutation invalidating the activating cleavage site of the IL-36 receptor antagonist
Authors: Alizée Bozonnat
Florence Assan
Jérôme LeGoff
Emmanuelle Bourrat
Hervé Bachelez
Publication date: 01-10-2021
Publisher: Springer US
Keywords: Generalized Pustular Psoriasis
SARS-CoV-2
Published in: Journal of Clinical Immunology / Issue 7/2021
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-021-01076-6

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