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Archives of Orthopaedic and Trauma Surgery

Open Access 17-04-2024 | Gene Therapy in Oncology | Knee Arthroplasty

Orthobiologics in knee osteoarthritis, dream or reality?

Authors: Nicolaas Cyrillus Budhiparama, Dananjaya Putramega, Imelda Lumban-Gaol

Published in: Archives of Orthopaedic and Trauma Surgery

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Abstract

Cartilage restoration or repair, also known as orthobiologic therapy, is indicated after the failure of conservative or supportive treatment. However, there is paucity in evidence supporting the efficacy of orthobiologic therapy. The blood-derived products, such as platelet-rich plasma (PRP), is one of the commonly used orthobiologic therapy for knee osteoarthritis. Several studies have shown that PRP is superior to other treatments, but the anatomic changes are scarce. Treatment with mesenchymal stem cells (MSCs) offers the greatest potential for curing degenerative disease due to their self-renewal ability, ability to migrate towards injured tissues (homing/trafficking), and ability to promote repair and regeneration of osteochondral defects. However, ethical concerns and high costs remain major challenges associated with MSC therapy. Gene therapy, another promising orthobiologic therapy, is currently in phase II clinical trial and has shown promising results. The key factors for successful orthobiologic therapy include patient selection, appropriate dosing, treatment of underlying mechanical problems, age, severity, and cost-effectiveness.
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Metadata
Title
Orthobiologics in knee osteoarthritis, dream or reality?
Authors
Nicolaas Cyrillus Budhiparama
Dananjaya Putramega
Imelda Lumban-Gaol
Publication date
17-04-2024
Publisher
Springer Berlin Heidelberg
Published in
Archives of Orthopaedic and Trauma Surgery
Print ISSN: 0936-8051
Electronic ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-024-05310-9