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Published in: Journal of the Association for Research in Otolaryngology 1/2023

04-01-2023 | Gene Therapy in Oncology | Review

Cochlear Health and Cochlear-implant Function

Authors: Kara C. Schvartz-Leyzac, Deborah J. Colesa, Donald L. Swiderski, Yehoash Raphael, Bryan E. Pfingst

Published in: Journal of the Association for Research in Otolaryngology | Issue 1/2023

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Abstract

The cochlear implant (CI) is widely considered to be one of the most innovative and successful neuroprosthetic treatments developed to date. Although outcomes vary, CIs are able to effectively improve hearing in nearly all recipients and can substantially improve speech understanding and quality of life for patients with significant hearing loss. A wealth of research has focused on underlying factors that contribute to success with a CI, and recent evidence suggests that the overall health of the cochlea could potentially play a larger role than previously recognized. This article defines and reviews attributes of cochlear health and describes procedures to evaluate cochlear health in humans and animal models in order to examine the effects of cochlear health on performance with a CI. Lastly, we describe how future biologic approaches can be used to preserve and/or enhance cochlear health in order to maximize performance for individual CI recipients.
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Metadata
Title
Cochlear Health and Cochlear-implant Function
Authors
Kara C. Schvartz-Leyzac
Deborah J. Colesa
Donald L. Swiderski
Yehoash Raphael
Bryan E. Pfingst
Publication date
04-01-2023
Publisher
Springer US
Published in
Journal of the Association for Research in Otolaryngology / Issue 1/2023
Print ISSN: 1525-3961
Electronic ISSN: 1438-7573
DOI
https://doi.org/10.1007/s10162-022-00882-y

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