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Published in:

01-11-2010

Gene Therapy for Erectile Dysfunction: What Is the Future?

Authors: Arnold Melman, Kelvin Davies

Published in: Current Urology Reports | Issue 6/2010

Abstract

Gene transfer for the treatment of erectile dysfunction has completed phase 1 safety testing and has shown the necessary safety to proceed to the next level of clinical trial. This review focuses on the background of the components of that have led to US Food and Drug Administration acceptance of human gene transfer trials for nonlethal disease.

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•• Christ GJ, Andersson KE, Williams K, et al.: Smooth-Muscle-Specific Gene Transfer with the Human Maxi-K Channel Improves Erectile Function and Enhances Sexual Behavior in Atherosclerotic Cynomolgus Monkeys. Eur Urol 2008 Dec 25 (Epub ahead of print). This report demonstrates the versatility of plasmid-based therapy. In this case, the hSlo gene was used in a plasmid backbone with a smooth muscle–activated-only promoter. In addition, it demonstrated that the product could correct erectile dysfunction that was caused by atherosclerosis in a primate model.

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• Porst H, Vardi Y, Akkus E, et al.: Standards for clinical trials in male sexual dysfunctions. J Sex Med 2010, 7:414–444. This wonderful review forms a basis of understanding for the basic requirements of clinical trials.CrossRefPubMed

Title: Gene Therapy for Erectile Dysfunction: What Is the Future?
Authors: Arnold Melman
Kelvin Davies
Publication date: 01-11-2010
Publisher: Current Science Inc.
Published in: Current Urology Reports / Issue 6/2010
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI: https://doi.org/10.1007/s11934-010-0145-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gene Therapy for Erectile Dysfunction: What Is the Future?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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