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Endocrine
Published in: Endocrine 2/2018

01-08-2018 | Original Article

Gender-specific differences of interaction between cadmium exposure and obesity on prediabetes in the NHANES 2007–2012 population

Authors: Fei Jiang, Xueyuan Zhi, Miao Xu, Bingyan Li, Zengli Zhang

Published in: Endocrine | Issue 2/2018

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Abstract

Purpose

Data from National Health and Nutrition Examination Survey (NHANES) for the years 2007–2012 were used to evaluate the interactions of cadmium (Cd) exposure with being overweight/obesity on the risk of prediabetes among adults 20 years older.

Methods

A total of 3552 subjects were included in the analysis. Urinary cadmium levels (UCd) was used as a biomarker for long-term exposure to Cd. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S).

Results

Following covariates adjustments, we found significant associations of UCd with higher prediabetes prevalence, and this association was more apparent in males (Q4 vs Q1: OR = 1.95, 95%CI: 1.34–2.84); while overweight/obesity was associated with prediabetes both in males and in females. Additionally, there was a significant interaction between Cd exposure and being overweight/obesity on prediabetes risk among males (RERI = 1.18, 95% CI: 0.42–1.93; AP = 0.35, 95% CI: 0.12–0.58; S = 2.00, 95% CI: 0.92–4.34).

Conclusions

Our results suggest that being overweight/obesity may substantially amplify the adverse effects of long-term cadmium exposure on prediabetes risk, and this interaction is more severe in male adults. Further studies are needed to confirm these findings.
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Metadata
Title
Gender-specific differences of interaction between cadmium exposure and obesity on prediabetes in the NHANES 2007–2012 population
Authors
Fei Jiang
Xueyuan Zhi
Miao Xu
Bingyan Li
Zengli Zhang
Publication date
01-08-2018
Publisher
Springer US
Published in
Endocrine / Issue 2/2018
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-018-1623-3

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