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European Archives of Oto-Rhino-Laryngology

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08-01-2024 | Gastroesophageal Reflux Disease | Rhinology

Causal analysis between gastroesophageal reflux disease and chronic rhinosinusitis

Authors: Gui Chen, Wucheng Guo, Shenrong Liu, Yingqi Wang, Xiaowen Zhang

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2024

Abstract

Background

Gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) have been shown to be potentially closely related, but the relationship between these conditions, particularly the possibility of a causal link, is not fully understood. This study used Mendelian randomization (MR) to assess the causal relationship between these two disorders.

Methods

We extracted genome-wide association study data sets for GERD and CRS from publicly available gene summaries, and used MR to conduct a causal inference analysis. The main robustness test used in this study included MR-Egger regression, a leave-one-out sensitivity test, and multivariate MR (MVMR).

Results

GERD increased the risk of developing CRS by 36%, based on the inverse-variance weighted method, a statistically significant association (odds ratio [OR] 1.360, 95% confidence interval [CI] 1.179–1.568, P < 0.001). Other MR assessment methods, such as weighted median, simple mode, and weighted mode, similarly observed a significant increase in the risk of CRS occurrence (OR 1.434, 95% CI 1.186–1.734, P < 0.001; OR 1.927, 95% CI 1.166–3.184, P = 0.013; and OR 1.910, 95% CI 1.222–2.983, P = 0.006, respectively). No significant bias was found in the heterogeneity or pleiotropy tests (P = 0.071 and P = 0.700, respectively). Even after excluding possible mediators using MVMR, GERD appeared to significantly increase the risk of developing CRS (OR 1.013, 95% CI 1.008–1.023, P = 0.002).

Conclusions

This study provides new, significant evidence that GERD is genetically associated with a higher incidence rate of CRS. However, further research is needed to elucidate the potential underlying biological mechanisms of this relationship.

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Title: Causal analysis between gastroesophageal reflux disease and chronic rhinosinusitis
Authors: Gui Chen
Wucheng Guo
Shenrong Liu
Yingqi Wang
Xiaowen Zhang
Publication date: 08-01-2024
Publisher: Springer Berlin Heidelberg
Keywords: Gastroesophageal Reflux Disease
Rhinosinusitis
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08350-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Causal analysis between gastroesophageal reflux disease and chronic rhinosinusitis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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