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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2021

Open Access 01-12-2021 | Gastroesophageal Reflux Disease | Research article

Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

Authors: Shu-Leei Tey, Chi-Ying Li, Li-Wei Lin, Li-Ching Chang, Yea-Ling Chen, Fang-Rong Chang, San-Nan Yang, Ching-Chung Tsai

Published in: BMC Complementary Medicine and Therapies | Issue 1/2021

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Abstract

Background

Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility.

Methods

We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES.

Results

The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES.

Conclusion

A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.
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Metadata
Title
Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors
Authors
Shu-Leei Tey
Chi-Ying Li
Li-Wei Lin
Li-Ching Chang
Yea-Ling Chen
Fang-Rong Chang
San-Nan Yang
Ching-Chung Tsai
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2021
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-021-03442-8

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