Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Gastroenterology
Published in: BMC Gastroenterology 1/2023

Open Access 01-12-2023 | Gastric Cancer | Research

Histopathological features of glandular atrophy of the lamina propria of the gastric mucosa during its occurrence and development

Authors: Yang-kun Wang, Dong-mei Ran, Ying-ying Li, Chao-ya Zhu, Ren-bing Zhang, Bo Jiang, Su-nan Wang

Published in: BMC Gastroenterology | Issue 1/2023

Login to get access

Abstract

Objective

To explore the histopathological features of glandular atrophy of the lamina propria of gastric mucosa during its occurrence and development.

Method

We performed detailed histological observation and immunohistochemical examination on the endoscopic biopsy and ESD endoscopic resection specimens of 896 patients with glandular atrophy of the lamina propria of gastric mucosa. The EnVision two-step method was used for immunohistochemical staining, and the slices were incubated with primary antibody CK7, CK20, villin, CDX2, MUC5AC, MUC6, p53 and ki-67. Hematoxylin staining was performed and observed under the microscope and statistically analyzed.

Results

In the initial stage of glandular atrophy of the lamina propria, the proliferation area of the deep gastric pits, and the isthmus and neck of the gastric glands are characterized by roughly normal structure of the glandular structure, increased mesenchyme, and widened space between glands. Subsequently, the gland becomes smaller in volume and less in number, especially at the base, in the gastric glandular part of the gastric unit. The disease at this stage has higher incidence, and occurs more often in the elderly who account for 64.0% (573/896) of our study group. The disease in this stage may exhibit some lesions that are physiologic (age-related degeneration) while others are pathological. Therefore, this condition is called simple glandular atrophy of the lamina propria of the gastric mucosa. When the gastric mucosal epithelium is subjected to infection or repeated infections, chemical stimuli, immune factors, and genetic factors, it can lead to the proliferation and transformation of stem cells in the proliferation area of the deep gastric pits, and the isthmus and neck of the gastric glands, forming single ducts, multiple ducts, or a proliferation of patchy cells. Then, atypical hyperplasia (intraepithelial neoplasia) presents, finally leading to gastric adenocarcinoma.

Conclusion

Understanding the histopathological characteristics of glandular atrophy of the lamina propria of gastric mucosa is of great significance in controlling the occurrence and development of gastric cancer.
Literature
1.
Cho JH, Jeon SR, Jin SY, Park S. Standard vs magnifying narrow-band imaging endoscopy for diagnosis of Helicobacter pylori Infection and gastric precancerous conditions. World J Gastroenterol. 2021;27(18):2238–50.CrossRefPubMedPubMedCentral
2.
Ishikawa T, Matsumura T, Okimoto K, Nagashima A, Shiratori W, Kaneko T, Oura H, Tokunaga M, Akizue N, Ohta Y, Saito K, Arai M, Kato J. Kato N.Efficacy of texture and Color Enhancement Imaging in visualizing gastric mucosal atrophy and gastric Neoplasms. Sci Rep. 2021;11(1):6910.CrossRefPubMedPubMedCentral
3.
Fernández-Esparrach G, Marín-Gabriel JC, de Tejada AH, Albéniz E, Nogales O, Del Pozo-García AJ, Rosón PJ, Goicotxea U, Uchima H, Terán A, Alberto A, Joaquín RS, Liseth RS, José S. En representación del grupo de DSE de la SEED.Implementation of endoscopic submucosal dissection in a country with a low incidence of gastric cancer: results from a prospective national registry. United Eur Gastroenterol J. 2021;9(6):718–26.CrossRef
4.
Matysiak-Budnik T, Camargo MC, Piazuelo MB, Leja M. Recent guidelines on the management of patients with gastric atrophy: common points and controversies. Dig Dis Sci. 2020;65(7):1899–903.CrossRefPubMed
5.
Mezmale L, Isajevs S, Bogdanova I, Polaka I, Krigere A, Rudzite D, Rudule A, Kikuste I, Parshutin S, Tazhedinov A, Mushinskiy D, Sametayev D, Belikhina T, Igissinov N, Park JY, Herrero R, Leja M. Prevalence of Atrophic Gastritis in Kazakhstan and the Accuracy of Pepsinogen tests to detect gastric mucosal atrophy. Asian Pac J Cancer Prev. 2019;20(12):3825–9.CrossRefPubMedPubMedCentral
6.
Massironi S, Zilli A, Elvevi A, Invernizzi P. The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective. Autoimmun Rev. 2019;18(3):215–22.CrossRefPubMed
7.
Kim HJ, Kim N, Yun CY, Lee HS. The clinical meaning of the indefinite for atrophy lesions within gastric mucosa biopsy specimens in a region with a high prevalence of gastric cancer. Helicobacter. 2019;24(5):e12605.CrossRefPubMed
8.
Bockerstett KA, Osaki LH, Petersen CP, Cai CW, Wong CF, Nguyen TM, Ford EL, Hoft DF, Mills JC, Goldenring JR, DiPaolo RJ. Interleukin-17A promotes parietal cell atrophy by inducing apoptosis. Cell Mol Gastroenterol Hepatol. 2018;5(4):678–690e1.CrossRefPubMedPubMedCentral
9.
Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 1996;20(10):1161-81.
10.
11.
Genta RM. Review article: gastric atrophy and atrophic gastritis–nebulous concepts in search of a definition. Aliment Pharmacol Ther. 1998;12(Suppl 1):17–23.CrossRefPubMed
12.
Rugge M, Correa P, Dixon MF, Fiocca R, Hattori T, Lechago J, Leandro G, Price AB, Sipponen P, Solcia E, Watanabe H, Genta RM. Gastric mucosal atrophy: interobserver consistency using new criteria for classification and grading. Aliment Pharmacol Ther. 2002;16(7):1249–59.CrossRefPubMed
13.
Crafa P, Russo M, Miraglia C, Barchi A, Moccia F, Nouvenne A, Leandro G, Meschi T. De’ angelis GL, Di Mario F.From Sidney to OLGA: an overview of atrophic gastritis. Acta Biomed. 2018;89(8–S):93–9.PubMed
14.
Yang-kun. Wang.Gastric Tumor pathology[M]//Chun-fang Gao,Yang-kun Wang, Editor-in-Chief.Digestive oncology. Beijing:People’s Military Medical Publishing House; 2012. pp. 296–404.
15.
Wang YK, Shen L, Yun T, Yang BF, Zhu CY, Wang SN. Histopathological classification and follow-up analysis of chronic atrophic gastritis. World J Clin Cases. 2021;9(16):3838–47.CrossRefPubMedPubMedCentral
16.
Wang YK, Zhou JL, Meng NL, Zhu CY, Wang SN, Chen XD. How does Helicobacter pylori Infection cause gastric mucosal atrophy. Infect Drug Resist. 2022;15:3619–29.CrossRefPubMedPubMedCentral
17.
Bockerstett KA, Lewis SA, Noto CN, Ford EL, Saenz JB, Jackson NM, Ahn TH, Mills JC, DiPaolo RJ. Single-cell transcriptional analyses identify lineage-specific epithelial responses to inflammation and Metaplastic Development in the gastric Corpus. Gastroenterology. 2020;159(6):2116–2129e4.CrossRefPubMed
18.
19.
Rodriguez-Castro KI, Franceschi M, Noto A, Miraglia C, Nouvenne A, Leandro G, Meschi T. De’ angelis GL, Di Mario F.Clinical manifestations of chronic atrophic gastritis. Acta Biomed. 2018;89(8–S):88–92.PubMed
20.
21.
Cavalcoli F, Zilli A, Conte D, Massironi S. Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: a review. World J Gastroenterol. 2017;23(4):563–72.CrossRefPubMedPubMedCentral
22.
Rugge M, Bricca L, Guzzinati S, Sacchi D, Pizzi M, Savarino E, Farinati F, Zorzi M, Fassan M, Dei Tos AP, Malfertheiner P, Genta RM, Graham DY. Autoimmune gastritis: long-term natural history in naïve Helicobacter pylori-negative patients. Gut. 2023;72(1):30–8.CrossRefPubMed
23.
Rugge M, Genta RM, Malfertheiner P, Graham DY. Gastric cancer risk in autoimmune gastritis: evidence versus opinion. Gut. 2023 Feb;27:gutjnl–2023.
24.
Genta RM, Turner KO, Robiou C, Singhal A, Rugge M. Incomplete intestinal metaplasia is Rare in Autoimmune Gastritis. Dig Dis. 2023;41(3):369–76.CrossRefPubMed
25.
Rugge M, Genta RM, Bricca L, Savarino E. Not all autoimmune gastritis are created the same. Gastroenterol Res. 2021;14(6):348–9.CrossRef
26.
Kotelevets SM, Chekh SA. Screening, monitoring, and treatment of Precancerous Atrophic Gastritis in the prospective study for seven years. Asian Pac J Cancer Prev. 2020;21(2):331–6.CrossRefPubMedPubMedCentral
27.
Mejías-Luque RS. A novel driver of Helicobacter pylori-Induced gastric atrophy. Cell Mol Gastroenterol Hepatol. 2021;11(3):887–8.CrossRefPubMed
28.
Russi S, Calice G, Ruggieri V, Laurino S, La Rocca F, Amendola E, Lapadula C, Compare D, Nardone G, Musto P, De Felice M, Falco G, Zoppoli P. Gastric normal adjacent mucosa Versus Healthy and Cancer tissues: distinctive transcriptomic profiles and Biological features. Cancers (Basel). 2019;11(9):1248.CrossRefPubMed
29.
Souza SM, Valiente AEF, Sá KM, Juanes CC, Rodrigues BJ, Farias ACC, Campelo CC, Silva PGB, Almeida PRC. Immunoexpression of LGR4 and beta-catenin in gastric Cancer and normal gastric mucosa. Asian Pac J Cancer Prev. 2019;20(2):519–27.CrossRefPubMedPubMedCentral
30.
Tarnawski AS, Ahluwalia A. Increased susceptibility of aging gastric mucosa to injury and delayed healing: clinical implications. World J Gastroenterol. 2018;24(42):4721–7.CrossRefPubMedPubMedCentral
31.
Heidari Z, Mahmoudzadeh-Sagheb H, Narouei M. Quantitative changes of gastric mucosa during carcinogenesis using stereological methods. J BUON. 2017 Jul-Aug;22(4):905–10.
32.
Mills. Stacey E.Histology for pathologists:editor, Stacey E. Mills 2012 Chap. 23.
33.
Wang Yk G, Cf, Yun T, Chen Z, Zhang Xw L, Xx M, Nl, Zhao Wz. Assessment of ERBB2 and EGFR gene amplification and protein expression in gastric carcinoma by immunohistochemistry and fluorescence in situ hybridization. Mol Cytogenet. 2011;4(1):14.CrossRefPubMed
34.
Wang YK, Chen Z, Yun T, Li CY, Jiang B, Lv XX, Chu GH, Wang SN, Yan H, Shi LF. Human epidermal growth factor receptor 2 expression in mixed gastric carcinoma. World J Gastroenterol. 2015;21(15):4680–7.CrossRefPubMedPubMedCentral
35.
Wang YK, Wang SN, Li YY, Wang GP, Yun T, Zhu CY, Yang BF, Li CY, Jiang B, Zhu ML. Methods and significance of the combined detection of HER2 gene amplification and chemosensitivity in gastric cancer. Cancer Biomark. 2018;21(2):439–47.CrossRefPubMed
36.
Tian Yun S, Wang B, Jiang C, Wang N, Meng X, Yuan Y, Wang. Significance of detection of the HER2 gene and PD-1/PD-L1 in gastric Cancer. J Oncol. 2020;2020:8678945.PubMedPubMedCentral
37.
Necula L, Matei L, Dragu D, Neagu AI, Mambet C, Nedeianu S, Bleotu C, Diaconu CC. Chivu-Economescu M.Recent advances in gastric cancer early diagnosis. World J Gastroenterol. 2019;25(17):2029–44.CrossRefPubMedPubMedCentral
38.
Jin S, Jeon SW, Kwon Y, Nam SY, Yeo SJ, Kwon SH, Lee SJ. Optimal endoscopic screening interval for early detection of gastric Cancer: a single-center study. J Korean Med Sci. 2018;33(23):e166.CrossRefPubMedPubMedCentral
39.
Shinozaki S, Osawa H, Hayashi Y, Lefor AK, Yamamoto H. Linked color imaging for the detection of early gastrointestinal Neoplasms. Th Adv Gastroenterol. 2019;12:1756284819885246.
40.
Barros R, Freund JN, David L, Almeida R. Gastric intestinal metaplasia revisited: function and regulation of CDX2. Trends Mol Med. 2012;18(9):555–63.CrossRefPubMed
41.
Mizoshita T, Inada K, Tsukamoto T, Kodera Y, Yamamura Y, Hirai T, Kato T, Joh T, Itoh M, Tatematsu M. Expression of Cdx1 and Cdx2 mRNAs and relevance of this expression to differentiation in human gastrointestinal mucosa–with special emphasis on participation in intestinal metaplasia of the human stomach. Gastric Cancer. 2001;4(4):185–91. https://​doi.​org/​10.​1007/​pl00011741. PMID: 11846061.CrossRefPubMed
42.
43.
Metadata
Title
Histopathological features of glandular atrophy of the lamina propria of the gastric mucosa during its occurrence and development
Authors
Yang-kun Wang
Dong-mei Ran
Ying-ying Li
Chao-ya Zhu
Ren-bing Zhang
Bo Jiang
Su-nan Wang
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2023
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-023-03033-6

Other articles of this Issue 1/2023

BMC Gastroenterology 1/2023 Go to the issue

Research

Young adults with colon cancer: clinical features and surgical outcomes

Research article

Impact of comorbidities on hospital mortality in patients with acute pancreatitis: a population-based study of 110,021 patients

Research

Prognostic assessment capability of a five-gene signature in pancreatic cancer: a machine learning based-study

Research

Multicentre prospective study to evaluate effectiveness and safety of gel-forming and hyaluronic-acid containing chewable tablets as add-on treatment in patients with gastroesophageal reflux disease (GERD) symptoms and unsatisfying proton pump inhibitor therapy

Research

International diet quality index and revised diet quality index relationship with non-alcoholic fatty liver disease: a case-control study

Research

Risk factors for the mortality of hepatitis B virus-associated acute-on-chronic liver failure: a systematic review and meta-analysis
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits