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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 13/2023

13-10-2023 | Gastric Cancer | ASO Author Reflections

ASO Author Reflections: A Role for Neoadjuvant Radiation in the Treatment of Locally Advanced Gastric Cancer?

Authors: Caressa Hui, MD, Lucas K. Vitzthum, MD, MS

Published in: Annals of Surgical Oncology | Issue 13/2023

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Excerpt

Perioperative chemotherapy and adjuvant chemoradiation therapy have been shown to improve outcomes versus surgery alone in the treatment of locally advanced gastric cancer.1,2 More recently, studies have found that the addition of adjuvant radiotherapy to multi-agent chemotherapy does not reduce recurrence after D2 gastrectomy. Although the general cohort of patients treated with gastrectomy and multi-agent chemotherapy does not benefit from adjuvant radiotherapy, it is possible that there is a subset of patients with a dominant risk of locoregional recurrence that could benefit. …
Literature
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Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019;393:1948–57. https://​doi.​org/​10.​1016/​S0140-6736(18)32557-1.CrossRefPubMed
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Leong T, Smithers BM, Haustermans K, et al. TOPGEAR: a randomized, phase III trial of perioperative ECF chemotherapy with or without preoperative chemoradiation for resectable gastric cancer: interim results from an international, intergroup trial of the AGITG, TROG, EORTC, and CCTG. Ann Surg Oncol. 2017;24:2252–8. https://​doi.​org/​10.​1245/​s10434-017-5830-6.CrossRefPubMed
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Slagter AE, Jansen EPM, van Laarhoven HWM, et al. CRITICS-II: a multicentre randomised phase II trial of neo-adjuvant chemotherapy followed by surgery versus neo-adjuvant chemotherapy and subsequent chemoradiotherapy followed by surgery versus neo-adjuvant chemoradiotherapy followed by surgery in resectable gastric cancer. BMC Cancer. 2018;18:877. https://​doi.​org/​10.​1186/​s12885-018-4770-2.CrossRefPubMedPubMedCentral
Metadata
Title
ASO Author Reflections: A Role for Neoadjuvant Radiation in the Treatment of Locally Advanced Gastric Cancer?
Authors
Caressa Hui, MD
Lucas K. Vitzthum, MD, MS
Publication date
13-10-2023
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 13/2023
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-023-14403-5

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