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01-12-2021 | Gastric Cancer | Research article

Trastuzumab-based palliative chemotherapy for HER2-positive gastric cancer: a single-center real-world data

Authors: Tae-Hwan Kim, Hun Do Cho, Yong Won Choi, Hyun Woo Lee, Seok Yun Kang, Geum Sook Jeong, Jin-Hyuk Choi, Mi Sun Ahn, Seung-Soo Sheen

Published in: BMC Cancer | Issue 1/2021

Abstract

Background

Since the results of the ToGA trial were published, trastuzumab-based chemotherapy has been used as the standard first-line treatment for HER2-positive recurrent or primary metastatic gastric cancer (RPMGC). However, the real-world data has been rarely reported. Therefore, we investigated the outcomes of trastuzumab-based chemotherapy in a single center.

Methods

This study analyzed the real-world data of 47 patients with HER2-positive RPMGC treated with trastuzumab-based chemotherapy in a single institution.

Results

With the median follow-up duration of 18.8 months in survivors, the median overall survival (OS) and progression-free survival were 12.8 and 6.9 months, respectively, and the overall response rate was 64%. Eastern Cooperative Oncology Group performance status 2 and massive amount of ascites were independent poor prognostic factors for OS, while surgical resection before or after chemotherapy was associated with favorable OS, in multivariate analysis. In addition, 5 patients who underwent conversion surgery after chemotherapy demonstrated an encouraging median OS of 30.8 months, all with R0 resection.

Conclusions

Trastuzumab-based chemotherapy in patients with HER2-positive RPMGC in the real world demonstrated outcomes almost comparable to those of the ToGA trial. Moreover, conversion surgery can be actively considered in fit patients with a favorable response after trastuzumab-based chemotherapy.

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Title: Trastuzumab-based palliative chemotherapy for HER2-positive gastric cancer: a single-center real-world data
Authors: Tae-Hwan Kim
Hun Do Cho
Yong Won Choi
Hyun Woo Lee
Seok Yun Kang
Geum Sook Jeong
Jin-Hyuk Choi
Mi Sun Ahn
Seung-Soo Sheen
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Gastric Cancer
Ascites
Gastric Cancer
Trastuzumab
Cytostatic Therapy
Published in: BMC Cancer / Issue 1/2021
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08058-2

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Abstract

Background

Methods

Results

Conclusions

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