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01-08-2013 | Original Contributions

Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-α. Prospective Clinical Trial

Authors: Elaine Cristina Viana, Karine L. Araujo-Dasilio, Gustavo Peixoto Soares Miguel, Josefina Bressan, Elenice Moreira Lemos, Margareth Ribeiro Moyses, Gláucia Rodrigues de Abreu, João Luiz Moreira Coutinho de Azevedo, Perseu Seixas Carvalho, Maria Rita S. Passos-Bueno, Flávia Imbroisi Valle Errera, Nazaré Souza Bissoli

Published in: Obesity Surgery | Issue 8/2013

Abstract

Background

Due to the association between the quantity of adipose tissue and concentrations of interleukin-6 (IL-6) and tumor necrosis factor (TNF-α), this work aimed to assess the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) procedures on serum IL-6 and TNF-α concentrations.

Methods

This study evaluated serum IL-6 and TNF-α levels, as well as routine anthropometric and biochemical values, before and 1 year post-bariatric surgery. Fifty percent of patients (n = 24) underwent RYGB, and 50 % (n = 24) underwent SG. Prior to bariatric surgery, IL-6 and TNF-α mRNA expression levels in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) were investigated in obese women.

Results

There was a significant reduction (p < 0.05) in all anthropometric and routine biochemical measurements in patients in the RYGB and SG groups 1 year post-surgery. The serum concentrations of IL-6 and TNF-α were reduced following surgery in both groups (p < 0.05). No differences in the relative expression levels of IL-6 and TNF-α were found between SAT and VAT prior to bariatric surgery.

Conclusions

RYGB and SG procedures demonstrated a similar impact on adipokine levels in women 1 year post-surgery. Both techniques may improve the course of chronic diseases and the state of inflammation associated with obesity.

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Title: Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-α. Prospective Clinical Trial
Authors: Elaine Cristina Viana
Karine L. Araujo-Dasilio
Gustavo Peixoto Soares Miguel
Josefina Bressan
Elenice Moreira Lemos
Margareth Ribeiro Moyses
Gláucia Rodrigues de Abreu
João Luiz Moreira Coutinho de Azevedo
Perseu Seixas Carvalho
Maria Rita S. Passos-Bueno
Flávia Imbroisi Valle Errera
Nazaré Souza Bissoli
Publication date: 01-08-2013
Publisher: Springer US
Published in: Obesity Surgery / Issue 8/2013
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-013-0894-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Gastric Bypass and Sleeve Gastrectomy: the Same Impact on IL-6 and TNF-α. Prospective Clinical Trial

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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