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Malaria Journal
Published in: Malaria Journal 1/2004

Open Access 01-12-2004 | Review

Gametocytogenesis : the puberty of Plasmodium falciparum

Authors: Arthur M Talman, Olivier Domarle, F Ellis McKenzie, Frédéric Ariey, Vincent Robert

Published in: Malaria Journal | Issue 1/2004

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Abstract

The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P. falciparum has evolved a remarkable biology and adaptive phenotypes to insure its transmission despite the dangers of sex. This review mainly focuses on the current knowledge on commitment to sexual development, gametocytogenesis and the evolutionary significance of various aspects of gametocyte biology. It goes further than pure biology to look at the strategies used to improve successful transmission. Although gametocytes are inevitable stages for transmission and provide a potential target to fight malaria, they have received less attention than the pathogenic asexual stages. There is a need for research on gametocytes, which are a fascinating stage, responsible to a large extent for the success of P. falciparum.
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Metadata
Title
Gametocytogenesis : the puberty of Plasmodium falciparum
Authors
Arthur M Talman
Olivier Domarle
F Ellis McKenzie
Frédéric Ariey
Vincent Robert
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2004
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-3-24

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