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Endocrine
Published in: Endocrine 2/2018

01-05-2018 | Research Letter

Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?

Authors: Juliana de Moraes Rodrigues, Dhemerson Souza de Lima, Vinicius N. C. Leal, Adriana A. Bosco, Valeria Sandrim, Alessandra Pontillo

Published in: Endocrine | Issue 2/2018

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Excerpt

Inflammation represents a cause, but also a consequence of obesity, contributing to disrupt metabolic homeostasis. Previously associated to high fat diets and physical inactivity, the contribution of gut microbiota and genetic inheritance are also being evaluated as risk factors for obesity. [1] …
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Metadata
Title
Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?
Authors
Juliana de Moraes Rodrigues
Dhemerson Souza de Lima
Vinicius N. C. Leal
Adriana A. Bosco
Valeria Sandrim
Alessandra Pontillo
Publication date
01-05-2018
Publisher
Springer US
Published in
Endocrine / Issue 2/2018
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-017-1343-0

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