Top

Published in:

01-08-2010 | Review

G protein-coupled receptor 30 in tumor development

Authors: Dengfeng Wang, Lina Hu, Guonan Zhang, Lin Zhang, Chen Chen

Published in: Endocrine | Issue 1/2010

Abstract

Estrogen plays several important physiological and pathological functions in not only reproductive system but many other systems as well. Its transcriptional activation has been traditionally described as being mediated by classic nuclear estrogen receptors (ERs). It is however established recently that a novel functional estrogen transmembrane receptor, G protein-coupled receptor 30 (GPR30), modulates both rapid non-genomic events and genomic transcriptional events of estrogen. It has been demonstrated that GPR30 promotes the progress of estrogen-related tumors through mitogen-activated protein kinase (MAPK) signaling pathways. Effects mediated by GPR30 are maintained when classic ERs are absent or blocked. In addition, GPR30 is involved in drug resistance, which is often occurring during cancer treatments. All these new findings strongly imply that GPR30 may be an important therapeutic target for estrogen-related tumors. Simultaneously blocking both GPR30 and classic ERs may be a better strategy for the treatment of estrogen-related tumors.

G.R. Frank, Med. Pediatr. Oncol. 41, 217–221 (2003)CrossRefPubMed

L. Baker, K.K. Meldrum, M. Wang et al., J. Surg. Res. 115, 325–344 (2003)CrossRefPubMed

C.D. Toran-Allerand, Endocrinology 145, 1069–1074 (2004)CrossRefPubMed

E.J. Kovacs, K.A. Messingham, M.S. Gregory, Mol. Cell. Endocrinol. 193, 129–135 (2002)CrossRefPubMed

E.V. Jensen, E.R. DeSombre, Science 182, 126–134 (1973)CrossRefPubMed

G.G. Kuiper, E. Enmark, M. Pelto-Huikko, S. Nilsson, J.A. Gustafsson, Proc Natl Acad Sci USA 93, 5925–5930 (1996)CrossRefPubMed

J.M. Hall, J.F. Couse, K.S. Korach, J. Biol. Chem. 276, 36869–36872 (2001)CrossRefPubMed

G.G. Kuiper, B. Carlsson, K. Grandien et al., Endocrinology 138, 863–870 (1997)CrossRefPubMed

K. Dechering, C. Boersma, S. Mosselman, Curr. Med. Chem. 7, 561–576 (2000)PubMed

10.

G.G. Chen, Q. Zeng, G.M. Tse, Med. Res. Rev. 28, 954–974 (2008)CrossRefPubMed

11.

A. Strom, J. Hartman, J.S. Foster et al., Proc. Natl. Acad. Sci. USA 101, 1566–1571 (2004)CrossRefPubMed

12.

L.A. Helguero, M.H. Faulds, J.A. Gustafsson, L.A. Haldosen, Oncogene 24, 6605–6616 (2005)CrossRefPubMed

13.

Z. Weihua, S. Saji, S. Makinen et al., Proc. Natl. Acad. Sci. USA 97, 5936–5941 (2000)CrossRefPubMed

14.

W.A. Ricke, S.J. McPherson, J.J. Bianco et al., FASEB J. 22, 1512–1520 (2008)CrossRefPubMed

15.

J. Cheng, E.J. Lee, L.D. Madison, G. Lazennec, FEBS Lett. 566, 169–172 (2004)CrossRefPubMed

16.

Q. Zeng, G.G. Chen, A.C. Vlantis, C.A. van Hasselt, Cell Prolif. 40, 921–935 (2007)CrossRefPubMed

17.

E.R. Prossnitz, L.A. Sklar, T.I. Oprea, J.B. Arterburn, Trends Pharmacol. Sci. 29, 116–123 (2008)PubMed

18.

E.R. Prossnitz, J.B. Arterburn, L.A. Sklar, Mol. Cell. Endocrinol. 265–266, 138–142 (2007)CrossRefPubMed

19.

E.J. Filardo, J.A. Quinn, A.R. Frackelton Jr., K.I. Bland, Mol. Endocrinol. 16, 70–84 (2002)CrossRefPubMed

20.

P. Thomas, Y. Pang, E.J. Filardo, J. Dong, Endocrinology 146, 624–632 (2005)CrossRefPubMed

21.

L. Albanito, A. Madeo, R. Lappano et al., Cancer Res. 67, 1859–1866 (2007)CrossRefPubMed

22.

E.R. Prossnitz, T.I. Oprea, L.A. Sklar, J.B. Arterburn, J Steroid Biochem. Mol. Biol. 109, 350–353 (2008)CrossRefPubMed

23.

M. Maggiolini, A. Vivacqua, G. Fasanella et al., J. Biol. Chem. 279, 27008–27016 (2004)CrossRefPubMed

24.

Y. Takada, C. Kato, S. Kondo, R. Korenaga, J. Ando, Biochem. Biophys. Res. Commun. 240, 737–741 (1997)CrossRefPubMed

25.

C. Owman, P. Blay, C. Nilsson, S.J. Lolait, Biochem. Biophys. Res. Commun. 228, 285–292 (1996)CrossRefPubMed

26.

C. Carmeci, D.A. Thompson, H.Z. Ring, U. Francke, R.J. Weigel, Genomics 45, 607–617 (1997)CrossRefPubMed

27.

B.F. O’Dowd, T. Nguyen, A. Marchese et al., Genomics 47, 310–313 (1998)CrossRefPubMed

28.

E.J. Filardo, J.A. Quinn, K.I. Bland, A.R. Frackelton Jr., Mol. Endocrinol. 14, 1649–1660 (2000)CrossRefPubMed

29.

Y.Y. He, B. Cai, Y.X. Yang, X.L. Liu, X.P. Wan, Cancer Sci. 100(6), 1051–1061 (2009)CrossRefPubMed

30.

E.J. Filardo, C.T. Graeber, J.A. Quinn et al., Clin. Cancer Res. 12, 6359–6366 (2006)CrossRefPubMed

31.

Z. Zhang, L. Duan, X. Du et al., Prostate 68, 508–516 (2008)CrossRefPubMed

32.

E. Haas, M.R. Meyer, U. Schurr et al., Hypertension 49, 1358–1363 (2007)CrossRefPubMed

33.

E.R. Hugo, T.D. Brandebourg, J.G. Woo et al., Environ. Health Perspect. 116, 1642–1647 (2008)CrossRefPubMed

34.

L. Albanito, D. Sisci, S. Aquila et al., Endocrinology 149, 3799–3808 (2008)CrossRefPubMed

35.

C. Wang, E.R. Prossnitz, S.K. Roy, Endocrinology 148, 4853–4864 (2007)CrossRefPubMed

36.

F. Gobeil, A. Fortier, T. Zhu et al., Can. J. Physiol. Pharmacol. 84, 287–297 (2006)CrossRefPubMed

37.

T. Funakoshi, A. Yanai, K. Shinoda, M.M. Kawano, Y. Mizukami, Biochem. Biophys. Res. Commun. 346, 904–910 (2006)CrossRefPubMed

38.

E. Filardo, J. Quinn, Y. Pang et al., Endocrinology 148, 3236–3245 (2007)CrossRefPubMed

39.

C.M. Revankar, D.F. Cimino, L.A. Sklar, J.B. Arterburn, E.R. Prossnitz, Science 307, 1625–1630 (2005)CrossRefPubMed

40.

C.M. Revankar, H.D. Mitchell, A.S. Field et al., ACS Chem. Biol. 2, 536–544 (2007)CrossRefPubMed

41.

C. Wang, E.R. Prossnitz, S.K. Roy, Endocrinology 149, 4452–4461 (2008)CrossRefPubMed

42.

K. Matsuda, H. Sakamoto, H. Mori et al., Neurosci. Lett. 441, 94–99 (2008)CrossRefPubMed

43.

C. Otto, B. Rohde-Schulz, G. Schwarz et al., Endocrinology 149, 4846–4856 (2008)CrossRefPubMed

44.

C.G. Bologa, C.M. Revankar, S.M. Young et al., Nat. Chem. Biol. 2, 207–212 (2006)CrossRefPubMed

45.

A. Vivacqua, D. Bonofiglio, A.G. Recchia et al., Mol. Endocrinol. 20, 631–646 (2006)CrossRefPubMed

46.

A. Vivacqua, D. Bonofiglio, L. Albanito et al., Mol. Pharmacol. 70, 1414–1423 (2006)CrossRefPubMed

47.

D.P. Pandey, R. Lappano, L. Albanito et al., EMBO J. 28, 523–532 (2009)CrossRefPubMed

48.

P. Thomas, J. Dong, J. Steroid Biochem. Mol. Biol. 102, 175–179 (2006)CrossRefPubMed

49.

K. Leblanc, E. Sexton, S. Parent et al., Int. J. Oncol. 30, 477–487 (2007)PubMed

50.

R.E. Muller, T.C. Johnston, A.M. Traish, H.H. Wotiz, Adv. Exp. Med. Biol. 117, 401–421 (1979)PubMed

51.

G.M. Dick, A.C. Hunter, K.M. Sanders, Mol. Pharmacol. 61, 1105–1113 (2002)CrossRefPubMed

52.

C. Hermenegildo, A. Cano, Hum. Reprod. Update 6, 237–243 (2000)CrossRefPubMed

53.

I. Vivanco, C.L. Sawyers, Nat. Rev. Cancer 2, 489–501 (2002)CrossRefPubMed

54.

G. Posern, R. Treisman, Trends Cell Biol. 16, 588–596 (2006)CrossRefPubMed

55.

A. Gutierrez-Hartmann, D.L. Duval, A.P. Bradford, Trends Endocrinol. Metab. 18, 150–158 (2007)CrossRefPubMed

56.

W.H. Kuo, L.Y. Chang, D.L. Liu et al., Taiwan J. Obstet. Gynecol. 46, 135–145 (2007)CrossRefPubMed

57.

E.J. Filardo, J Steroid Biochem. Mol. Biol. 80, 231–238 (2002)CrossRefPubMed

58.

E.J. Filardo, J.A. Quinn, E. Sabo, Steroids 73, 870–873 (2008)CrossRefPubMed

59.

H.O. Smith, K.K. Leslie, M. Singh et al. Am. J. Obstet. Gynecol. 196, 386 e381–389; discussion 386 e389–311 (2007)

60.

E. Henic, V. Noskova, G. Hoyer-Hansen, S. Hansson, B. Casslen, Int. J. Gynecol. Cancer 19, 214–222 (2009)PubMed

61.

L. Albanito, R. Lappano, A. Madeo et al., Environ. Health Perspect. 116, 1648–1655 (2008)CrossRefPubMed

62.

R.A. Alyea, S.E. Laurence, S.H. Kim et al., J. Neurochem. 106, 1525–1533 (2008)CrossRefPubMed

63.

Z. Liu, X. Yu, Z.A. Shaikh, Toxicol. Appl. Pharmacol. 228, 286–294 (2008)CrossRefPubMed

64.

K. Kang, S.B. Lee, S.H. Jung et al., Mol. Cells 27, 351–357 (2009)CrossRefPubMed

65.

B. Kleuser, D. Malek, R. Gust, H.H. Pertz, H. Potteck, Mol. Pharmacol. 74, 1533–1543 (2008)CrossRefPubMed

66.

E.W. Lapensee, T.R. Tuttle, S.R. Fox, N. Ben-Jonathan, Environ. Health Perspect. 117, 175–180 (2009)PubMed

67.

L.I. Gold, Crit. Rev. Oncog. 10, 303–360 (1999)PubMed

68.

G.I. Evan, K.H. Vousden, Nature 411, 342–348 (2001)CrossRefPubMed

69.

A.J. Ridley, M.A. Schwartz, K. Burridge et al., Science 302, 1704–1709 (2003)CrossRefPubMed

70.

D. Hanahan, R.A. Weinberg, Cell 100, 57–70 (2000)CrossRefPubMed

71.

M.B. Sporn, Lancet 347, 1377–1381 (1996)CrossRefPubMed

72.

P.L. Fitzgibbons, D.L. Page, D. Weaver et al., Arch. Pathol. Lab. Med. 124, 966–978 (2000)PubMed

73.

D.M. Parkin, F. Bray, J. Ferlay, P. Pisani, CA Cancer J. Clin. 55, 74–108 (2005)CrossRefPubMed

74.

B. Hanstein, S. Djahansouzi, P. Dall, M.W. Beckmann, H.G. Bender, Eur. J. Endocrinol. 150, 243–255 (2004)CrossRefPubMed

75.

S. Ali, R.C. Coombes, J Mammary Gland Biol. Neoplasia 5, 271–281 (2000)CrossRefPubMed

76.

Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Lancet 365, 1687–1717 (2005)

77.

O. Treeck, B. Wackwitz, U. Haus, O. Ortmann, Gynecol. Oncol. 102, 292–299 (2006)CrossRefPubMed

78.

J.Z. Yang, C. O’Flatharta, B.J. Harvey, W. Thomas, Steroids 73, 1110–1122 (2008)CrossRefPubMed

79.

N.G. Azios, S.F. Dharmawardhane, Neoplasia 7, 128–140 (2005)CrossRefPubMed

80.

J.M. Rey, P. Pujol, P. Callier et al., J. Mol. Endocrinol. 24, 433–440 (2000)CrossRefPubMed

81.

R. Strick, S. Ackermann, M. Langbein et al., J. Mol. Med. 85, 23–38 (2007)CrossRefPubMed

82.

E.R. Prossnitz, J.B. Arterburn, H.O. Smith et al., Annu. Rev. Physiol. 70, 165–190 (2008)CrossRefPubMed

Title: G protein-coupled receptor 30 in tumor development
Authors: Dengfeng Wang
Lina Hu
Guonan Zhang
Lin Zhang
Chen Chen
Publication date: 01-08-2010
Publisher: Springer US
Published in: Endocrine / Issue 1/2010
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-010-9363-z

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits

STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2010

Functional interactions between pancreatic beta cells and (pre)adipocytes

Liver failure due to antithyroid drugs: report of a case and literature review

MicroRNA expression in ACTH-producing pituitary tumors: up-regulation of microRNA-122 and -493 in pituitary carcinomas

The transcription factor prolactin regulatory element-binding protein mediates prolactin transcription induced by thyrotropin-releasing hormone in GH3 cells

SRC-3 deficient mice developed fat redistribution under high-fat diet

Diet-induced obesity, exogenous leptin-, and MADB106 tumor cell challenge affect tissue leukocyte distribution and serum levels of cytokines in F344 rats

Highlights from the ACC 2024 Congress

ACC 2024 Congress Coverage