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Journal of Translational Medicine
Published in: Journal of Translational Medicine 1/2012

Open Access 01-12-2012 | Meeting report

FUTURE PERSPECTIVES IN MELANOMA RESEARCH. Meeting report from the “Melanoma Research: a bridge from Naples to the World. Napoli, December 5th–6 th2011”

Authors: Paolo A Ascierto, Antonio M Grimaldi, Brendan Curti, Mark B Faries, Soldano Ferrone, Keith Flaherty, Bernard A Fox, Thomas F Gajewski, Jeffrey E Gershenwald, Helen Gogas, Kenneth Grossmann, Axel Hauschild, F Stephen Hodi, Richard Kefford, John M Kirkwood, Sancy Leachmann, Michele Maio, Richard Marais, Giuseppe Palmieri, Donald L Morton, Antoni Ribas, David F Stroncek, Rodney Stewart, Ena Wang, Nicola Mozzillo, Franco M Marincola

Published in: Journal of Translational Medicine | Issue 1/2012

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Abstract

After more than 30 years, landmark progress has been made in the treatment of cancer, and melanoma in particular, with the success of new molecules such as ipilimumab, vemurafenib and active specific immunization.
After the first congress in December 2010, the second edition of “Melanoma Research: a bridge from Naples to the World” meeting, organized by Paolo A. Ascierto (INT, Naples, Italy), Francesco M. Marincola (NIH, Bethesda, USA), and Nicola Mozzillo (INT, Naples, Italy) took place in Naples, on 5–6 December 2011. We have identified four new topics of discussion: Innovative Approaches in Prevention, Diagnosis and Surgical Treatment, New Pathways and Targets in Melanoma: An Update about Immunotherapy, and Combination Strategies.
This international congress gathered more than 30 international faculty members and was focused on recent advances in melanoma molecular biology, immunology and therapy, and created an interactive atmosphere which stimulated discussion of new approaches and strategies in the field of melanoma.
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Literature
1.
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB, Byrd DR, Buzaid AC, Cochran AJ, Coit DG, Ding S, Eggermont AM, Flaherty KT, Gimotty P, Kirkwood JM, McMasters KM, Mihm MC, Morton DL, Ross MI, Sober AJ, Sondak VK: Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009, 27: 6199-6206. 10.1200/JCO.2009.23.4799.CrossRefPubMedPubMedCentral
2.
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Ding S, Byrd David R, Cascinelli N, Cochran AJ, Coit DG, Eggermont AM, Johnson T, Kirkwood JM, Leong SP, McMasters KM, Mihm MC, Morton DL, Ross MI, Sondak VK: Multivariate analysis of prognostic factors among 2,313 patients with stage III melanoma: comparison of nodal micrometastases versus macrometastases. J Clin Oncol. 2010, 28: 2452-2459. 10.1200/JCO.2009.27.1627.CrossRefPubMedPubMedCentral
3.
Balch CM, Gershenwald JE, Soong SJ, Thompson JF, Atkins MB: Melanoma of the skin. AJCC Cancer Staging Manual (ed 7th). Edited by: Edge SE, Byrd DR, Carducci MA. 2009, Springer, New York
4.
Thompson JF, Soong SJ, Balch CM, Gershenwald JE, Ding S, Coit DG, Flaherty KT, Gimotty PA, Johnson T, Johnson MM, Leong SP, Ross MI, Byrd DR, Cascinelli N, Cochran AJ, Eggermont AM, McMasters KM, Mihm MC, Morton DL, Sondak VK: Prognostic significance of mitotic rate in localized primary cutaneous melanoma: an analysis of patients in the multi-institutional American Joint Committee on Cancer melanoma staging database. J Clin Oncol. 2011, 29: 2199-2205. 10.1200/JCO.2010.31.5812.CrossRefPubMedPubMedCentral
5.
Gershenwald JE, Soong SJ, Balch CM: 2010 TNM staging system for cutaneous melanoma…and beyond. Ann Surg Oncol. 2010, 17: 1475-1477. 10.1245/s10434-010-0986-3.CrossRefPubMed
6.
Bowles TL, Xing Y, Hu CY, Mungovan KS, Askew RL, Chang GJ, Gershenwald JE, Lee JE, Mansfield PF, Ross MI, Cormier JN: Conditional survival estimates improve over 5 years for melanoma survivors with node-positive disease. Ann Surg Oncol. 2010, 17: 2015-2023. 10.1245/s10434-010-1051-y.CrossRefPubMed
7.
Jakob JA, Bassett RL, Ng CS, Curry JL, Joseph RW, Alvarado GC, Rohlfs ML, Richard J, Gershenwald JE, Kim KB, Lazar AJ, Hwu P, Davies MA: NRAS mutation status is an independent prognostic factor in metastatic melanoma. Cancer. 2011, 10.1002/cncr.26724. Dec 16
8.
Soong SJ, Ding S, Coit D, Balch CM, Gershenwald JE, Thompson JF, Gimotty P: Predicting survival outcome of localized melanoma: an electronic prediction tool based on the AJCC Melanoma Database. Ann Surg Oncol. 2010, 17: 2006-2014. 10.1245/s10434-010-1050-z.CrossRefPubMed
9.
10.
Puzanov I, Burnett P, Flaherty KT: Biological challenges of BRAF inhibitor therapy. Mol Oncol. 2011, 5: 116-123. 10.1016/j.molonc.2011.01.005.CrossRefPubMed
11.
Curran K, Lister JA, Kunkel GR, Prendergast A, Parichy DM, Raible DW: Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Dev Biol. 2010, 344: 107-118. 10.1016/j.ydbio.2010.04.023.CrossRefPubMedPubMedCentral
12.
Thomas AJ, Erickson CA: FOXD3 regulates the lineage switch between neural crest-derived glial cells and pigment cells by repressing MITF through a non-canonical mechanism. Development. 2009, 136: 1849-1858. 10.1242/dev.031989.CrossRefPubMedPubMedCentral
13.
Curran K, Raible DW, Lister JA: Foxd3 controls melanophore specification in the zebrafish neural crest by regulation of Mitf. Dev Biol. 2009, 332: 408-417. 10.1016/j.ydbio.2009.06.010.CrossRefPubMedPubMedCentral
14.
Stewart RA: Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell. 2010, 18: 750-762. 10.1016/j.devcel.2010.03.009.CrossRefPubMedPubMedCentral
15.
Abel EV, Aplin AE: FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells. Cancer Res. 2010, 70: 2891-2900. 10.1158/0008-5472.CAN-09-3139.CrossRefPubMedPubMedCentral
16.
Katiyar P, Aplin AE: FOXD3 Regulates Migration Properties and Rnd3 Expression in Melanoma Cells. Mol Cancer Res. 2011, 9: 545-552. 10.1158/1541-7786.MCR-10-0454.CrossRefPubMedPubMedCentral
17.
Stroncek DF, Berger C, Cheever MA, Childs RW, Dudley ME, Flynn P, Gattinoni L, Heath JR, Kalos M, Marincola FM, Miller JS, Mostoslavsky G, Powell DJ, Rao M, Restifo NP, Rosenberg SA, O’Shea J, Melief CJ: New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer. J Transl Med. 2012 Mar 15, 10 (1): 48-10.1186/1479-5876-10-48.CrossRefPubMedPubMedCentral
18.
Dudley ME, Gross CA, Langhan MM, Garcia MR, Sherry RM, Yang JC, Phan GQ, Kammula US, Hughes MS, Citrin DE, Restifo NP, Wunderlich JR, Prieto PA, Hong JJ, Langan RC, Zlott DA, Morton KE, White DE, Laurencot CM, Rosenberg SA: CD8+ enriched “young” tumor infiltrating lymphocytes can mediate regression of metastatic melanoma. Clin Cancer Res. 2010 Dec 15, 16 (24): 6122-6131. 10.1158/1078-0432.CCR-10-1297.CrossRefPubMedPubMedCentral
19.
Rosenberg SA, Yang JC, Sherry RM, Kammula US, Hughes MS, Phan GQ, Citrin DE, Restifo NP, Robbins PF, Wunderlich JR, Morton KE, Laurencot CM, Steinberg SM, White DE, Dudley ME: Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res. 2011 Jul 1, 17 (13): 4550-4557. 10.1158/1078-0432.CCR-11-0116.CrossRefPubMedPubMedCentral
20.
Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, Kammula US, Hughes MS, Restifo NP, Raffeld M, Lee CC, Levy CL, Li YF, El-Gamil M, Schwarz SL, Laurencot C, Rosenberg SA: Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol. 2011 Mar 1, 29 (7): 917-924. 10.1200/JCO.2010.32.2537.CrossRefPubMedPubMedCentral
21.
Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP: A human memory T cell subset with stem cell-like properties. Nat Med. 2011 Sep 18, 17 (10): 1290-1297. 10.1038/nm.2446.CrossRefPubMedPubMedCentral
22.
Jin J, Sabatino M, Somerville R, Wilson JR, Dudley ME, Stroncek DF, Rosenberg SA: Simplified Method of the Growth of Human Tumor Infiltrating Lymphocytes in Gas-permeable Flasks to Numbers Needed for Patient Treatment. J Immunother. 2012 Apr, 35 (3): 283-292. 10.1097/CJI.0b013e31824e801f.CrossRefPubMedPubMedCentral
23.
Kirkwood JM, Strawderman MH, Ernstoff MS, Smith TJ, Borden EC, Blum RH: Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol. 1996, 14: 7-17.PubMed
24.
Tatsumi T, Kierstead LS, Ranieri E, Gesualdo L, Schena FP, Finke JH, Bukowski RM, Mueller-Berghaus J, Kirkwood JM, Kwok WW, Storkus WJ: Disease-associated bias in T helper type 1 (Th1)/Th2 CD4(+) T cell responses against MAGE-6 in HLA-DRB10401(+) patients with renal cell carcinoma or melanoma. J Exp Med. 2002, 196: 619-628. 10.1084/jem.20012142.CrossRefPubMedPubMedCentral
25.
Wheatley K, Ives N, Hancock B, Gore M, Eggermont A, Suciu S: Does adjuvant interferon-alpha for high-risk melanoma provide a worthwhile benefit? A meta-analysis of the randomised trials. Cancer treatment reviews. 2003, 29: 241-252. 10.1016/S0305-7372(03)00074-4.CrossRefPubMed
26.
Wheatley K, Ives N, Eggermont A, Kirkwood J, Cascinelli N, Markovic SN, Hancock B, Lee S, Suciu S, on behalf of International Malignant Melanoma Collaborative Group: Interferon-α as adjuvant therapy for melanoma: An individual patient data meta-analysis of randomised trials [abstract]. Proc Am Soc Clin Oncol. 2007, 25 (abstr 8526): 478S-
27.
Mocellin S, Pasquali S, Rossi CR, Nitti D: Interferon Alpha Adjuvant Therapy in Patients With High-Risk Melanoma: A Systematic Review and Meta-analysis. J Natl Cancer Inst. 2010, 102: 493-501. 10.1093/jnci/djq009.CrossRefPubMed
28.
Agarwala SS, Lee SJ, Flaherty LE, Smylie M, Kefford RF, Carson WE, Cohen G, Kirkwood JM: Randomized phase III trial of high-dose interferon alfa-2b (HDI) for 4 weeks induction only in patients with intermediate- and high-risk melanoma (Intergroup trial E 1697). J Clin Oncol. 2011, 29 (suppl; abstr 8505): 5276s-
29.
Gogas H, Ioannovich J, Dafni U, Stavropoulou-Giokas C, Frangia K, Tsoutsos D, Panagiotou P, Polyzos A, Papadopoulos O, Stratigos A, Markopoulos C, Bafaloukos D, Pectasides D, Fountzilas G, Kirkwood JM: Prognostic significance of autoimmunity during treatment of melanoma with interferon. N Engl J Med. 2006, 354: 709-718. 10.1056/NEJMoa053007.CrossRefPubMed
30.
Tarhini AA, Edington H, Butterfield LH, Sinha M, Moschos SJ, Tawbi H, Shuai Y, Shipe-Spotloe J, Simonetta M, Milburn C, Horak M, Sander C, Kirkwood JM: Neoadjuvant ipilimumab in patients with stage IIIB/C melanoma: Immunogenicity and biomarker analysis. J Clin Oncol. 2011, 29 (suppl; abstr 8536): 534s-
31.
Tarhini AA, Cherian J, Moschos SJ, Tawbi HA, Shuai Y, Gooding WE, Sander C, Kirkwood JM: Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma. J Clin Oncol. 2012, 30: 322-328. 10.1200/JCO.2011.37.5394.CrossRefPubMedPubMedCentral
32.
Korn EL, Liu PY, Lee SJ, Chapman JA, Niedzwiecki D, Suman VJ, Moon J, Sondak VK, Atkins MB, Eisenhauer EA, Parulekar W, Markovic SN, Saxman S, Kirkwood JM: Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. J Clin Oncol. 2008, 26: 527-534. 10.1200/JCO.2007.12.7837.CrossRefPubMed
33.
Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJM, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ: Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010, 363: 711-723. 10.1056/NEJMoa1003466.CrossRefPubMedPubMedCentral
34.
Robert C, Thomas L, Bondarenko I, O’Day S, DJ M, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, Davidson N, Richards J, Maio M, Hauschild A, Miller WA, Gascon P, Lotem M, Harmankaya K, Ibrahim R, Francis S, Chen T-T, Humphrey R, Hoos A, Wolchok JD: Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011, 364: 2517-2526. 10.1056/NEJMoa1104621.CrossRefPubMed
35.
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O’Day SJ, Sosman JA, Kirkwood JM, Eggermont AMM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA: Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011, 364: 2507-2516. 10.1056/NEJMoa1103782.CrossRefPubMedPubMedCentral
36.
Kim KB, Flaherty KT, Chapman PB, Sosman JA, Ribas A, McArthur GA, Amaravadi RK, Lee RJ, Nolop KB, Puzanov I: Pattern and outcome of disease progression in phase I study of vemurafenib in patients with metastatic melanoma (MM). J Clin Oncol. 2011, 29 (abstr 8519): 530s-
37.
Infante JR, Falchook GS, Lawrence DP, Weber JS, Kefford RF, Bendell JC, Kurzrock R, Shapiro G, Kudchadkar RR, Long GV, Burris A, Kim KB, Clements A, Peng S, Yi B, Allred AJ, Ouellet D, Patel K, Lebowitz PF, Flaherty KT: Phase I/II study to assess safety, pharmacokinetics, and efficacy of the oral MEK 1/2 inhibitor GSK1120212 (GSK212) dosed in combination with the oral BRAF inhibitor GSK2118436 (GSK436). J Clin Oncol. 2011, 29 (abstr CRA8503): 526s-
38.
Ascierto PA, Marincola FM, Ribas A: Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application. J Transl Med. 2011, 9: 196-10.1186/1479-5876-9-196.CrossRefPubMedPubMedCentral
39.
Di Giacomo AM, Ascierto PA, Fonsatti E, Pittiglio E, Queirolo P, Pilla L, Ridolfi R, Santinami M, Testori A, Parmiani G, Maio M: A phase II study combining ipilimumab and fotemustine in patients with metastatic melanoma: The NIBIT-M1 trial. [2011 ASCO Meeting abstract TPS230]. J Clin Oncol. 2011, 29: TPS230-CrossRef
40.
Hodi FS, Friedlander PA, Atkins MB, McDermott DF, Lawrence DP, Ibrahim N, Wu X, Zhou J, Giobbie-Hurder A, Murphy G, Hollman T, Velazquez E, Russell S, Dipiro P, Yap JT, Van Den Abbeele AD: A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma. J Clin Oncol. 2011, 29 (suppl; abstr 8511): 529s-
Metadata
Title
FUTURE PERSPECTIVES IN MELANOMA RESEARCH. Meeting report from the “Melanoma Research: a bridge from Naples to the World. Napoli, December 5th–6 th2011”
Authors
Paolo A Ascierto
Antonio M Grimaldi
Brendan Curti
Mark B Faries
Soldano Ferrone
Keith Flaherty
Bernard A Fox
Thomas F Gajewski
Jeffrey E Gershenwald
Helen Gogas
Kenneth Grossmann
Axel Hauschild
F Stephen Hodi
Richard Kefford
John M Kirkwood
Sancy Leachmann
Michele Maio
Richard Marais
Giuseppe Palmieri
Donald L Morton
Antoni Ribas
David F Stroncek
Rodney Stewart
Ena Wang
Nicola Mozzillo
Franco M Marincola
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2012
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-10-83

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