Published in:
01-04-2012 | Immunology in Serbia
Functional properties of granulocytes after thermal injury
Authors:
Biljana Draskovic-Pavlovic, Dragana Vucevic, Biljana Bozic, Ivana Majstorovic, Miodrag Colic
Published in:
Immunologic Research
|
Issue 1-2/2012
Login to get access
Abstract
Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increased accumulation of granulocytes in the lungs or liver, the results from our laboratory demonstrated reduced granulocyte influx in the wound that heals in conditions of thermal injury. We also demonstrated evidence that indicates impaired signal transduction in granulocytes following thermal injury, as well as their divergent response regarding the adhesiveness, oxidative burst and nitric oxide production at the wound site.