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Immunologic Research
Published in: Immunologic Research 1-2/2012

01-04-2012 | Immunology in Serbia

Trichinella spiralis: shaping the immune response

Authors: Natasa Ilic, Alisa Gruden-Movsesijan, Ljiljana Sofronic-Milosavljevic

Published in: Immunologic Research | Issue 1-2/2012

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Abstract

The co-evolution of a wide range of helminth parasites and vertebrates represented a constant pressure on the host’s immune system and a selective force for shaping the immune response. Modulation of the immune system by parasites is accomplished partly by dendritic cells. When exposed to helminth parasites or their products, dendritic cells do not become classically mature and are potent inducers of Th2 and regulatory responses. Treating animals with helminths (eggs, larvae, extracts) causes dampening or in some cases prevention of allergic or autoimmune diseases. Trichinella spiralis (T. spiralis) possess a capacity to retune the immune cell repertoire, acting as a moderator of the host response not only to itself but also to third party antigens. In this review, we will focus on the ability of T. spiralis-stimulated dendritic cells to polarize the immune response toward Th2 and regulatory mode in vitro and in vivo and also on the capacity of this parasite to modulate autoimmune disease—such as experimental autoimmune encephalomyelitis.
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Metadata
Title
Trichinella spiralis: shaping the immune response
Authors
Natasa Ilic
Alisa Gruden-Movsesijan
Ljiljana Sofronic-Milosavljevic
Publication date
01-04-2012
Publisher
Springer-Verlag
Published in
Immunologic Research / Issue 1-2/2012
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-012-8287-5

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