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Current HIV/AIDS Reports
Published in: Current HIV/AIDS Reports 3/2014

01-09-2014 | Co-infections and Comorbidity (CM Wyatt and K Sigel, Section Editors)

Functional Impairment, Disability, and Frailty in Adults Aging with HIV-Infection

Authors: Kristine M. Erlandson, Jennifer A. Schrack, Catherine M. Jankowski, Todd T. Brown, Thomas B. Campbell

Published in: Current HIV/AIDS Reports | Issue 3/2014

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Abstract

The integration of antiretroviral therapy (i.e., ART) into HIV care has dramatically extended the life expectancy of those living with HIV. However, in comparison to similar HIV-uninfected populations, HIV-infected persons experience an excess of morbidity and mortality with an early onset of aging complications including neurocognitive decline, osteoporosis, impaired physical function, frailty, and falls. Recent consensus guidelines encourage clinicians and researchers to consider functional impairment of HIV-infected adults as a measure to understand the impact of aging across a range of abilities. Despite the importance of assessing function in persons aging with HIV infection, a lack of consistent terminology and standardization of assessment tools has limited the application of functional assessments in clinical or research settings. Herein, we distinguish between different approaches used to assess function, describe what is known about function in the aging HIV population, and consider directions for future research.
Literature
1.
Effros RB, Fletcher CV, Gebo K, Halter JB, Hazzard WR, Horne FM, et al. Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions. Clin Infect Dis. 2008;47:542–53.PubMedCentralPubMed
2.••
Summary report from the Human Immunodeficiency Virus and Aging Consensus Project: treatment strategies for clinicians managing older individuals with the human immunodeficiency virus. J Am Geriatr Soc 2012,60:974-979. This is a nice summary of the key points from the HIV and Aging Consensus Project document and highlights issues in clinical care and research priorities.
3.
Guaraldi G, Orlando G, Zona S, Menozzi M, Carli F, Garlassi E, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis. 2011;53:1120–6.PubMed
4.
Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 2008,372:293-299.
5.
Sacktor N, Skolasky RL, Cox C, Selnes O, Becker JT, Cohen B, et al. Longitudinal psychomotor speed performance in human immunodeficiency virus-seropositive individuals: impact of age and serostatus. J Neurovirol. 2010;16:335–41.PubMedCentralPubMed
6.
Womack JA, Goulet JL, Gibert C, Brandt C, Chang CC, Gulanski B, et al. Increased risk of fragility fractures among HIV infected compared to uninfected male veterans. PLoS One. 2011;6:e17217.PubMedCentralPubMed
7.
Young B, Dao CN, Buchacz K, Baker R, Brooks JT. Increased rates of bone fracture among HIV-infected persons in the HIV Outpatient Study (HOPS) compared with the US general population, 2000-2006. Clin Infect Dis. 2011;52:1061–8.PubMed
8.
Walker Harris V, Brown TT. Bone loss in the HIV-infected patient: evidence, clinical implications, and treatment strategies. J Infect Dis. 2012;205 Suppl 3:S391–8.PubMedCentralPubMed
9.
Erlandson KM, Allshouse AA, Jankowski CM, Duong S, Mawhinney S, Kohrt WM, et al. Comparison of functional status instruments in HIV-infected adults on effective antiretroviral therapy. HIV Clin Trials. 2012;13:324–34.PubMed
10.
Oursler KK, Sorkin JD, Smith BA, Katzel LI. Reduced aerobic capacity and physical functioning in older HIV-infected men. AIDS Res Hum Retroviruses. 2006;22:1113–21.PubMed
11.
Richert L, Dehail P, Mercie P, Dauchy FA, Bruyand M, Greib C, et al. High frequency of poor locomotor performance in HIV-infected patients. AIDS. 2011;25:797–805.PubMed
12.
Desquilbet L, Jacobson LP, Fried LP, Phair JP, Jamieson BD, Holloway M, et al. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007;62:1279–86.PubMed
13.
Desquilbet L, Jacobson LP, Fried LP, Phair JP, Jamieson BD, Holloway M, et al. A frailty-related phenotype before HAART initiation as an independent risk factor for AIDS or death after HAART among HIV-infected men. J Gerontol A Biol Sci Med Sci. 2011;66:1030–8.PubMed
14.
Desquilbet L, Margolick JB, Fried LP, Phair JP, Jamieson BD, Holloway M, et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr. 2009;50:299–306.PubMedCentralPubMed
15.
Onen NF, Agbebi A, Shacham E, Stamm KE, Onen AR, Overton ET. Frailty among HIV-infected persons in an urban outpatient care setting. J Infect. 2009;59:346–52.PubMed
16.
Terzian AS, Holman S, Nathwani N, Robison E, Weber K, Young M, et al. Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART. J Womens Health. 2009;18:1965–74.
17.
Erlandson KM, Allshouse AA, Jankowski CM, Duong S, Mawhinney S, Kohrt WM, et al. Risk Factors for Falls in HIV-Infected Persons. J Acquir Immune Defic Syndr. 2012;61:484–9.PubMedCentralPubMed
18.
Holroyd-Leduc JM, Reddy M. Evidence-based geriatric medicine : a practical clinical guide. Chichester: Blackwell Pub; 2012.
19.
20.
21.••
High KP, Brennan-Ing M, Clifford DB, Cohen MH, Currier J, Deeks SG, et al. HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group. J Acquir Immunodef Syndr. 2012;60 Suppl 1:S1–18. A high yield summary of priority areas in HIV and Aging as identified by leaders and funding agencies.
22.
High KP, Bradley S, Loeb M, Palmer R, Quagliarello V, Yoshikawa T. A new paradigm for clinical investigation of infectious syndromes in older adults: assessment of functional status as a risk factor and outcome measure. Clin Infect Dis. 2005;40:114–22.PubMed
23.
Justice AC. HIV and aging: time for a new paradigm. Current HIV/AIDS reports. 2010;7:69–76.PubMed
24.
Nagi SZ. A Study in the Evaluation of Disability and Rehabilitation Potential: Concepts, Methods, and Procedures. Am J Public Health Nations Health. 1964;54:1568–79.PubMedCentralPubMed
25.
Verbrugge LM, Jette AM. The disablement process. Soc Sci Med. 1994;38:1–14.PubMed
26.
Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;332:556–61.PubMed
27.
Kelley AS, Ettner SL, Morrison RS, Du Q, Sarkisian CA. Disability and Decline in Physical Function Associated with Hospital Use at End of Life. J Gen Intern Med 2012
28.
Newman AB, Simonsick EM, Naydeck BL, Boudreau RM, Kritchevsky SB, Nevitt MC, et al. Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability. JAMA. 2006;295:2018–26.PubMed
29.
Rolland Y, Lauwers-Cances V, Cesari M, Vellas B, Pahor M, Grandjean H. Physical performance measures as predictors of mortality in a cohort of community-dwelling older French women. Eur J Epidemiol. 2006;21:113–22.PubMed
30.•
Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, et al. Gait speed and survival in older adults. JAMA. 2011;305:50–8. This landmark study demonstrates the remarkable ability of a simple measure of gait speed to predict mortality.PubMedCentralPubMed
31.
Vestergaard S, Patel KV, Bandinelli S, Ferrucci L, Guralnik JM. Characteristics of 400-meter walk test performance and subsequent mortality in older adults. Rejuvenation Res. 2009;12:177–84.PubMedCentralPubMed
32.
De Buyser SL, Petrovic M, Taes YE, Toye KR, Kaufman JM, Goemaere S. Physical function measurements predict mortality in ambulatory older men. Eur J Clin Invest. 2013;43:379–86.PubMed
33.
Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004;59:255–63.PubMed
34.
Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–86.PubMed
35.
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of Illness in the Aged. The Index of Adl: A Standardized Measure of Biological and Psychosocial Function. JAMA. 1963;185:914–9.PubMed
36.
Jette AM. Toward a common language of disablement. J Gerontol A Biol Sci Med Sci. 2009;64:1165–8.PubMed
37.
In: The Future of Disability in America. Edited by Field MJ, Jette AM. Washington (DC); 2007.
38.
Ustun TB, Chatterji S, Kostanjsek N, Rehm J, Kennedy C, Epping-Jordan J, et al. Developing the World Health Organization Disability Assessment Schedule 2.0. Bull World Health Organ. 2010;88:815–23.PubMedCentralPubMed
39.
Garin O, Ayuso-Mateos JL, Almansa J, Nieto M, Chatterji S, Vilagut G, et al. Validation of the "World Health Organization Disability Assessment Schedule, WHODAS-2" in patients with chronic diseases. Health Qual Life Outcomes. 2010;8:51.PubMedCentralPubMed
40.
Patrick DL, Erickson P. Health status and health policy : quality of life in health care evaluation and resource allocation. New York: Oxford University Press; 1993.
41.
42.
Cress ME, Schechtman KB, Mulrow CD, Fiatarone MA, Gerety MB, Buchner DM. Relationship between physical performance and self-perceived physical function. J Am Geriatr Soc. 1995;43:93–101.PubMed
43.
Wittink H, Rogers W, Sukiennik A, Carr DB. Physical functioning: self-report and performance measures are related but distinct. Spine. 2003;28:2407–13.PubMed
44.
Kempen GI, Steverink N, Ormel J, Deeg DJ. The assessment of ADL among frail elderly in an interview survey: self-report versus performance-based tests and determinants of discrepancies. J Gerontol B Psychol Sci Soc Sci. 1996;51:P254–60.PubMed
45.
Oursler KK, Katzel LI, Smith BA, Scott WB, Russ DW, Sorkin JD. Prediction of cardiorespiratory fitness in older men infected with the human immunodeficiency virus: clinical factors and value of the six-minute walk distance. J Am Geriatr Soc. 2009;57:2055–61.PubMedCentralPubMed
46.
Longenberger A, Lim JY, Brown TT, Abraham A, Palella FJ, Effros RB, et al. Low physical function as a risk factor for incident diabetes mellitus and insulin resistance. Futur Virol. 2011;6:439–49.
47.
Longenberger A, Lim JY, Orchard T, Brooks MM, Brach J, Mertz K, et al. Self-reported low physical function is associated with diabetes mellitus and insulin resistance in HIV-positive and HIV-negative men. Futur HIV Ther. 2008;2:539–49.PubMedCentralPubMed
48.
Oursler KK, Goulet JL, Leaf DA, Akingicil A, Katzel LI, Justice A, et al. Association of comorbidity with physical disability in older HIV-infected adults. AIDS Patient Care STDS. 2006;20:782–91.PubMed
49.
Rodriguez-Penney AT, Iudicello JE, Riggs PK, Doyle K, Ellis RJ, Letendre SL, et al. Co-morbidities in persons infected with HIV: increased burden with older age and negative effects on health-related quality of life. AIDS Patient Care STDS. 2013;27:5–16.PubMedCentralPubMed
50.
Stanton DL, Wu AW, Moore RD, Rucker SC, Piazza MP, Abrams JE, et al. Functional status of persons with HIV infection in an ambulatory setting. J Acquir Immune Defic Syndr. 1994;7:1050–6.PubMed
51.
Rusch M, Nixon S, Schilder A, Braitstein P, Chan K, Hogg RS. Impairments, activity limitations and participation restrictions: prevalence and associations among persons living with HIV/AIDS in British Columbia. Health Qual Life Outcomes. 2004;2:46.PubMedCentralPubMed
52.
Harding R, Clucas C, Lampe FC, Date HL, Fisher M, Johnson M, et al. What factors are associated with patient self-reported health status among HIV outpatients? A multi-centre UK study of biomedical and psychosocial factors. AIDS Care. 2012;24:963–71.PubMed
53.
Morgan EE, Iudicello JE, Weber E, Duarte NA, Riggs PK, Delano-Wood L, et al. Synergistic effects of HIV infection and older age on daily functioning. J Acquir Immune Defic Syndr. 2012;61:341–8.PubMedCentralPubMed
54.
Merlin JS, Westfall AO, Chamot E, Overton ET, Willig JH, Ritchie C, et al. Pain is Independently Associated with Impaired Physical Function in HIV-Infected Patients. Pain Med. 2013;14:1985–93.PubMed
55.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56.PubMed
56.
Fried LP, Xue QL, Cappola AR, Ferrucci L, Chaves P, Varadhan R, et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci. 2009;64:1049–57.PubMed
57.
Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, Chaves P, et al. Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci. 2006;61:262–6.PubMed
58.
Conroy S. Defining frailty–the Holy Grail of geriatric medicine. J Nutr Health Aging. 2009;13:389.PubMed
59.
Lang PO, Michel JP, Zekry D. Frailty syndrome: a transitional state in a dynamic process. Gerontology. 2009;55:539–49.PubMed
60.
Blaum CS, Xue QL, Tian J, Semba RD, Fried LP, Walston J. Is hyperglycemia associated with frailty status in older women? J Am Geriatr Soc. 2009;57:840–7.PubMed
61.
Drey M, Pfeifer K, Sieber CC, Bauer JM. The Fried frailty criteria as inclusion criteria for a randomized controlled trial: personal experience and literature review. Gerontology. 2011;57:11–8.PubMed
62.
Avila-Funes JA, Amieva H, Barberger-Gateau P, Le Goff M, Raoux N, Ritchie K, et al. Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city study. J Am Geriatr Soc. 2009;57:453–61.PubMed
63.
Gobbens RJ, van Assen MA, Luijkx KG, Wijnen-Sponselee MT, Schols JM. The Tilburg Frailty Indicator: psychometric properties. J Am Med Dir Assoc. 2010;11:344–55.PubMed
64.
Schuurmans H, Steverink N, Lindenberg S, Frieswijk N, Slaets JP. Old or frail: what tells us more? J Gerontol A Biol Sci Med Sci. 2004;59:M962–5.PubMed
65.
Rolfson DB, Majumdar SR, Tsuyuki RT, Tahir A, Rockwood K. Validity and reliability of the Edmonton Frail Scale. Age Ageing. 2006;35:526–9.PubMed
66.
Morley JE, Haren MT, Rolland Y, Kim MJ. Frailty. Med Clin North Am. 2006;90:837–47.PubMed
67.
Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci. 2007;62:738–43.PubMed
68.
Jones D, Song X, Mitnitski A, Rockwood K. Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians. Aging Clin Exp Res. 2005;17:465–71.PubMed
69.
Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K. A standard procedure for creating a frailty index. BMC Geriatr. 2008;8:24.PubMedCentralPubMed
70.
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381:752–62.PubMed
71.
Pialoux T, Goyard J, Lesourd B. Screening tools for frailty in primary health care: a systematic review. Geriatr Gerontol Int. 2012;12:189–97.PubMed
72.
Theou O, Brothers TD, Mitnitski A, Rockwood K. Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality. J Am Geriatr Soc. 2013;61:1537–51.PubMed
73.
Avila-Funes JA, Amieva H. Frailty: an overused term among the elderly… even in gastroenterology. J Clin Gastroenterol 2009,43:199; author reply 199.
74.
Margolick JB, Chopra RK. Relationship between the immune system and frailty: pathogenesis of immune deficiency in HIV infection and aging. Aging (Milano). 1992;4:255–7.
75.•
Althoff KN, Jacobson LP, Cranston RD, Detels R, Phair JP, Li X, et al. Age, Comorbidities, and AIDS Predict a Frailty Phenotype in Men Who Have Sex With Men. J Gerontol A Biol Sci Med Sci. 2013. doi:10.​1093/​gerona/​glt148. Using the frailty-related phenotype in the MACS Cohort, these authors provide the first data on the stability of the frail state among HIV-infected men and clinical risk factors associated with transition in or out of the frail state. PubMed
76.•
Piggott DA, Muzaale AD, Mehta SH, Brown TT, Patel KV, Leng SX, et al. Frailty, HIV infection, and mortality in an aging cohort of injection drug users. PLoS One. 2013;8:e54910. This study in a nicely matched cohort of HIV-infected and HIV-uninfected intravenous drug users demonstrates the synergistic effect of both frailty and HIV in predicting mortality. PubMedCentralPubMed
77.
Onen NF, Patel P, Baker J, Conley L, Brooks JT, Bush T, et al. Frailty and pre-frailty in a contemporary cohort of HIV-infected adults. The Journal of Frailty & Aging 2013
78.
Rees HC, Ianas V, McCracken P, Smith S, Georgescu A, Zangeneh T, et al. Measuring frailty in HIV-infected individuals. Identification of frail patients is the first step to amelioration and reversal of frailty. J Vis Exp 2013.
79.
Sandkovsky U, Robertson KR, Meza JL, High RR, Bonasera SJ, Fisher CM, et al. Pilot study of younger and older HIV-infected adults using traditional and novel functional assessments. HIV Clin Trials. 2013;14:165–74.PubMedCentralPubMed
80.
Pathai S, Gilbert C, Weiss HA, Cook C, Wood R, Bekker LG, et al. Frailty in HIV-infected adults in South Africa. J Acquir Immune Defic Syndr. 2013;62:43–51.PubMedCentralPubMed
81.
Morley JE, Perry HM, Miller DK. Editorial: Something About Frailty. J Gerontol A Biol Sci Med Sci. 2002;57:M698–704.PubMed
82.
Morley JE. Diabetes, sarcopenia, and frailty. Clin Geriatr Med. 2008;24:455–69.PubMed
83.
Sayers SP, Guralnik JM, Newman AB, Brach JS, Fielding RA. Concordance and discordance between two measures of lower extremity function: 400 meter self-paced walk and SPPB. Aging Clin Exp Res. 2006;18:100–6.PubMed
84.
Vasunilashorn S, Coppin AK, Patel KV, Lauretani F, Ferrucci L, Bandinelli S, et al. Use of the Short Physical Performance Battery Score to predict loss of ability to walk 400 meters: analysis from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2009;64:223–9.PubMed
85.
Cesari M, Onder G, Zamboni V, Manini T, Shorr RI, Russo A, et al. Physical function and self-rated health status as predictors of mortality: results from longitudinal analysis in the ilSIRENTE study. BMC Geriatr. 2008;8:34.PubMedCentralPubMed
86.
Justice AC, McGinnis KA, Skanderson M, Chang CC, Gibert CL, Goetz MB, et al. Towards a combined prognostic index for survival in HIV infection: the role of 'non-HIV' biomarkers. HIV Med. 2010;11:143–51.PubMedCentralPubMed
87.
Sourial N, Bergman H, Karunananthan S, Wolfson C, Payette H, Gutierrez-Robledo LM, et al. Implementing frailty into clinical practice: a cautionary tale. J Gerontol A Biol Sci Med Sci. 2013;68:1505–11.PubMed
88.
Simonsick EM, Newman AB, Nevitt MC, Kritchevsky SB, Ferrucci L, Guralnik JM, et al. Measuring higher level physical function in well-functioning older adults: expanding familiar approaches in the Health ABC study. J Gerontol A Biol Sci Med Sci. 2001;56:M644–9.PubMed
89.
De Lorenzo A, Meirelles V, Vilela F, Souza FC. Use of the exercise treadmill test for the assessment of cardiac risk markers in adults infected with HIV. J Int Assoc Provid AIDS Care. 2013;12:110–6.PubMed
90.
Mbada CE, Onayemi O, Ogunmoyole Y, Johnson OE, Akosile CO. Health-related quality of life and physical functioning in people living with HIV/AIDS: a case-control design. Health Qual Life Outcomes. 2013;11:106.PubMedCentralPubMed
91.
Mapstone M, Hilton TN, Yang H, Guido JJ, Luque AE, Hall WJ, et al. Poor Aerobic Fitness May Contribute to Cognitive Decline in HIV-infected Older Adults. Aging Dis. 2013;4:311–9.PubMedCentralPubMed
92.
Campo M, Oursler KK, Huang L, Goetz MB, Rimland D, Hoo GS, et al. Association of Chronic Cough and Pulmonary Function With 6-Minute Walk Test Performance in HIV Infection. JAIDS J Acquir Immune Defic Syndr. 2014;65:557–63.
93.
Grinspoon S, Corcoran C, Rosenthal D, Stanley T, Parlman K, Costello M, et al. Quantitative assessment of cross-sectional muscle area, functional status, and muscle strength in men with the acquired immunodeficiency syndrome wasting syndrome. J Clin Endocrinol Metab. 1999;84:201–6.PubMed
94.
Holguin A, Banda M, Willen EJ, Malama C, Chiyenu KO, Mudenda VC, et al. HIV-1 effects on neuropsychological performance in a resource-limited country, Zambia. AIDS Behav. 2011;15:1895–901.PubMedCentralPubMed
95.
Robertson KR, Parsons TD, Sidtis JJ, Hanlon Inman T, Robertson WT, Hall CD, et al. Timed Gait test: normative data for the assessment of the AIDS dementia complex. J Clin Exp Neuropsychol. 2006;28:1053–64.PubMed
96.
Robertson K, Jiang H, Kumwenda J, Supparatpinyo K, Evans S, Campbell TB, et al. Improved neuropsychological and neurological functioning across three antiretroviral regimens in diverse resource-limited settings: AIDS Clinical Trials Group study a5199, the International Neurological Study. Clin Infect Dis. 2012;55:868–76.PubMedCentralPubMed
97.
Crawford KW, Li X, Xu X, Abraham AG, Dobs AS, Margolick JB, et al. Lipodystrophy and inflammation predict later grip strength in HIV-infected men: the MACS Body Composition substudy. AIDS Res Hum Retroviruses. 2013;29:1138–45.PubMedCentralPubMed
98.
Negin J, Martiniuk A, Cumming RG, Naidoo N, Phaswana-Mafuya N, Madurai L, et al. Prevalence of HIV and chronic comorbidities among older adults. AIDS. 2012;26 Suppl 1:S55–63.PubMed
99.
Souza PM, Jacob-Filho W, Santarem JM, Zomignan AA, Burattini MN. Effect of progressive resistance exercise on strength evolution of elderly patients living with HIV compared to healthy controls. Clinics (Sao Paulo). 2011;66:261–6.
100.
Raso V, Shephard RJ. do Rosario Casseb JS, da Silva Duarte AJ, D'Andrea Greve JM. Handgrip force offers a measure of physical function in individuals living with HIV/AIDS. J Acquir Immune Defic Syndr. 2013;63:e30–2.PubMed
101.
Baranoski AS, Harris A, Michaels D, Miciek R, Storer T, Sebastiani P, et al. Relationship Between Poor Physical Function, Inflammatory Markers, and Comorbidities in HIV-Infected Women on Antiretroviral Therapy. J Womens Health (Larchmt). 2014;23:69–76.
102.•
Richert L, Brault M, Mercie P, Dauchy FA, Bruyand M, Greib C, et al. Decline in locomotor functions over time in HIV-infected patients. AIDS. 2014. doi:10.​1097/​QAD.​0000000000000246​. Although the follow-up time was short, this study provides some of the first rates of change in several measures of objective physical function, essential data needed to power future interventional studies to prevent physical function decline.
103.
Sullivan EV, Rosenbloom MJ, Rohlfing T, Kemper CA, Deresinski S, Pfefferbaum A. Pontocerebellar contribution to postural instability and psychomotor slowing in HIV infection without dementia. Brain Imaging Behav. 2011;5:12–24.PubMedCentralPubMed
104.
Wasserman P, Segal-Maurer S, Rubin DS. High Prevalence of Low Skeletal Muscle Mass Associated with Male Gender in Midlife and Older HIV-Infected Persons Despite CD4 Cell Reconstitution and Viral Suppression. J Int Assoc Provid AIDS Care. 2013. doi:10.​1177/​2325957413495919​.PubMed
105.
Bauer LO, Wu Z, Wolfson LI. An obese body mass increases the adverse effects of HIV/AIDS on balance and gait. Phys Ther. 2011;91:1063–71.PubMedCentralPubMed
106.
Bauer LO, Ceballos NA, Shanley JD, Wolfson LI. Sensorimotor dysfunction in HIV/AIDS: effects of antiretroviral treatment and comorbid psychiatric disorders. AIDS. 2005;19:495–502.PubMedCentralPubMed
107.
Fama R, Eisen JC, Rosenbloom MJ, Sassoon SA, Kemper CA, Deresinski S, et al. Upper and lower limb motor impairments in alcoholism, HIV infection, and their comorbidity. Alcohol Clin Exp Res. 2007;31:1038–44.PubMed
108.
Scott WB, Oursler KK, Katzel LI, Ryan AS, Russ DW. Central activation, muscle performance, and physical function in men infected with human immunodeficiency virus. Muscle Nerve. 2007;36:374–83.PubMedCentralPubMed
109.
Shah K, Hilton TN, Myers L, Pinto JF, Luque AE, Hall WJ. A new frailty syndrome: central obesity and frailty in older adults with the human immunodeficiency virus. J Am Geriatr Soc. 2012;60:545–9.PubMedCentralPubMed
Metadata
Title
Functional Impairment, Disability, and Frailty in Adults Aging with HIV-Infection
Authors
Kristine M. Erlandson
Jennifer A. Schrack
Catherine M. Jankowski
Todd T. Brown
Thomas B. Campbell
Publication date
01-09-2014
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 3/2014
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-014-0215-y

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The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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