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European Radiology
Published in: European Radiology 4/2016

01-04-2016 | Hepatobiliary-Pancreas

Functional gadoxetate disodium-enhanced MRI in patients with primary sclerosing cholangitis (PSC)

Authors: Heiko Hinrichs, Jan B. Hinrichs, Marcel Gutberlet, Henrike Lenzen, Hans-Juergen Raatschen, Frank Wacker, Kristina I. Ringe

Published in: European Radiology | Issue 4/2016

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Abstract

Objectives

To assess the value of variable flip angle-based T1 liver mapping on gadoxetate disodium-enhanced MRI in patients with primary sclerosing cholangitis (PSC) for evaluation of global and segmental liver function, and determine a possible correlation with disease severity.

Methods

Sixty-one patients (19 female, 42 male; mean age 41 years) with PSC were included in this prospective study. T1 mapping was performed using a 3D-spoiled GRE sequence (flip angles 5°, 15°, 20°, 30°) before, 16 (HP1) and 132 min (HP2) after contrast injection. T1 values were measured and compared (Wilcoxon-Test) by placing ROIs in each liver segment. The mean reduction of T1 relaxation time at HP1 and HP2 was calculated and correlated with liver function tests (LFTs), MELD, Mayo Risk and Amsterdam Scores (Spearman correlation).

Results

Significant changes of T1 relaxation times between non-enhanced and gadoxetate disodium-enhanced MRI at HP1 and HP2 could be observed in all liver segments (p < 0.0001). A significant correlation of T1 reduction could be observed with LFTs, MELD and Mayo Risk Score (p < 0.05).

Conclusions

T1 mapping of the liver using a variable flip angle-based sequence is a feasible technique to evaluate liver function on a global level, and may be extrapolated on a segmental level in patients with PSC.

Key Points

• T1 mapping enables evaluation of global liver function in PSC.
• T1 relaxation time reduction correlates with the MELD and MayoRisk Score.
• Extrapolated, T1 mapping may allow for segmental evaluation of liver function.
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Metadata
Title
Functional gadoxetate disodium-enhanced MRI in patients with primary sclerosing cholangitis (PSC)
Authors
Heiko Hinrichs
Jan B. Hinrichs
Marcel Gutberlet
Henrike Lenzen
Hans-Juergen Raatschen
Frank Wacker
Kristina I. Ringe
Publication date
01-04-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 4/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3913-y

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