Functional electrical stimulation of lower limbs in patients with chronic heart failure

go back to reference Sullivan MJ, Cobb FR (1992) Central hemodynamic response to exercise in patients with chronic heart failure. Chest 101(5 suppl):340S–346SPubMed Sullivan MJ, Cobb FR (1992) Central hemodynamic response to exercise in patients with chronic heart failure. Chest 101(5 suppl):340S–346SPubMed

go back to reference Franciosa JA, Park M, Levine TB (1981) Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol 47:33–39PubMed Franciosa JA, Park M, Levine TB (1981) Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol 47:33–39PubMed

go back to reference Wilson JR, Martin JL, Schwartz D et al (1984) Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle. Circulation 69:1079–1087PubMed Wilson JR, Martin JL, Schwartz D et al (1984) Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle. Circulation 69:1079–1087PubMed

go back to reference Cohn JN, Ferrari R, Sharpe N (2000) Cardiac remodeling: concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am Coll Cardiol 35:569–582PubMed Cohn JN, Ferrari R, Sharpe N (2000) Cardiac remodeling: concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am Coll Cardiol 35:569–582PubMed

go back to reference Brunner-La Rocca HP, Weilenmann D, Schalcher C et al (1999) Prognostic significance of oxygen uptake kinetics during low level exercise in patients with heart failure. Am J Cardiol 84:741–744PubMed Brunner-La Rocca HP, Weilenmann D, Schalcher C et al (1999) Prognostic significance of oxygen uptake kinetics during low level exercise in patients with heart failure. Am J Cardiol 84:741–744PubMed

go back to reference Nanas S, Nanas J, Kassiotis C et al (1999) Respiratory muscles performance is related to oxygen kinetics during maximal exercise and early recovery in patients with congestive heart failure. Circulation 100:503–508PubMed Nanas S, Nanas J, Kassiotis C et al (1999) Respiratory muscles performance is related to oxygen kinetics during maximal exercise and early recovery in patients with congestive heart failure. Circulation 100:503–508PubMed

go back to reference Puri S, Baker BL, Dutka DP, Oakley CM, Hughes JM, Cleland JG (1995) Reduced alveolar-capillary membrane diffusing capacity in chronic heart failure. Its pathophysiological relevance and relationship to exercise performance. Circulation 91(11):2769–2774PubMed Puri S, Baker BL, Dutka DP, Oakley CM, Hughes JM, Cleland JG (1995) Reduced alveolar-capillary membrane diffusing capacity in chronic heart failure. Its pathophysiological relevance and relationship to exercise performance. Circulation 91(11):2769–2774PubMed

go back to reference Clark AL, Volterrani M, Swan JW, Coats AJ (1997) The increased ventilatory response to exercise in chronic heart failure: relation to pulmonary pathology. Heart 77(2):138–146PubMed Clark AL, Volterrani M, Swan JW, Coats AJ (1997) The increased ventilatory response to exercise in chronic heart failure: relation to pulmonary pathology. Heart 77(2):138–146PubMed

go back to reference Wilson JR, Mancini DM (1993) Factors contributing to exercise limitation of heart failure. J Am Coll Cardiol 22(Suppl A):93A–98APubMed Wilson JR, Mancini DM (1993) Factors contributing to exercise limitation of heart failure. J Am Coll Cardiol 22(Suppl A):93A–98APubMed

go back to reference Drexler H, Riede U, Münzel T, König H, Funke E, Just H (1992) Alterations of skeletal muscle in chronic heart failure. Circulation 85:1751–1759PubMed Drexler H, Riede U, Münzel T, König H, Funke E, Just H (1992) Alterations of skeletal muscle in chronic heart failure. Circulation 85:1751–1759PubMed

go back to reference Mancini DM, Coyle E, Coggan A, Beltz J, Ferraro N, Montain S, Wilson JR (1989) Contribution of intrinsic skeletal muscle metabolic changes to 31P NMR skeletal muscle metabolic abnormalities in patients with chronic heart failure. Circulation 80:1338–1346PubMed Mancini DM, Coyle E, Coggan A, Beltz J, Ferraro N, Montain S, Wilson JR (1989) Contribution of intrinsic skeletal muscle metabolic changes to 31P NMR skeletal muscle metabolic abnormalities in patients with chronic heart failure. Circulation 80:1338–1346PubMed

go back to reference Sullivan MJ, Green HJ, Cobb FR (1991) Altered skeletal muscle metabolic response to exercise in chronic heart failure. Relation to skeletal muscle aerobic enzyme activity. Circulation 84:1868–1870 Sullivan MJ, Green HJ, Cobb FR (1991) Altered skeletal muscle metabolic response to exercise in chronic heart failure. Relation to skeletal muscle aerobic enzyme activity. Circulation 84:1868–1870

go back to reference Piepoli M, Clark AL, Coats AJ (1995) Muscle metaboreceptors in hemodynamic, autonomic, and ventilatory responses to exercise in men. Am J Physiol 269(4 Pt 2):H1428–H1436PubMed Piepoli M, Clark AL, Coats AJ (1995) Muscle metaboreceptors in hemodynamic, autonomic, and ventilatory responses to exercise in men. Am J Physiol 269(4 Pt 2):H1428–H1436PubMed

go back to reference Coats AJS (1993) Exercise rehabilitation in chronic heart failure. Am Coll Cardiol 22:172A–177A Coats AJS (1993) Exercise rehabilitation in chronic heart failure. Am Coll Cardiol 22:172A–177A

go back to reference Katz SD, Krum H, Khan T, Knecht M (1996) Exercise-induced vasodilation in forearm circulation of normal subjects and patients with congestive heart failure: role of endothelium-derived nitric oxide. J Am Coll Cardiol 28(3):585–590PubMed Katz SD, Krum H, Khan T, Knecht M (1996) Exercise-induced vasodilation in forearm circulation of normal subjects and patients with congestive heart failure: role of endothelium-derived nitric oxide. J Am Coll Cardiol 28(3):585–590PubMed

go back to reference Piña IL, Apstein CS, Balady JG, Belardinelli R, Chaitman BR, Duscha BD (2003) AHA scientific statement: exercise and heart failure. A statement from the American Heart Association Committee on exercise, rehabilitation and prevention. Circulation 107:1210–1225PubMed Piña IL, Apstein CS, Balady JG, Belardinelli R, Chaitman BR, Duscha BD (2003) AHA scientific statement: exercise and heart failure. A statement from the American Heart Association Committee on exercise, rehabilitation and prevention. Circulation 107:1210–1225PubMed

go back to reference Sullivan MJ, Hawthorne MH (1995) Exercise intolerance in patients with chronic heart failure. Prog Cardiovasc Dis 38:1–22PubMed Sullivan MJ, Hawthorne MH (1995) Exercise intolerance in patients with chronic heart failure. Prog Cardiovasc Dis 38:1–22PubMed

go back to reference Myers J, Froelicher VF (1991) Hemodynamic determinants of exercise capacity in chronic heart failure. Ann Int Med 115:377–386PubMed Myers J, Froelicher VF (1991) Hemodynamic determinants of exercise capacity in chronic heart failure. Ann Int Med 115:377–386PubMed

go back to reference Nakamura M, Ishikawa M, Funakoshi T et al (1994) Attenuated endothelium-dependent peripheral vasodilation and clinical characteristics in patients with chronic heart failure. Am Heart J 128:1164–1169PubMed Nakamura M, Ishikawa M, Funakoshi T et al (1994) Attenuated endothelium-dependent peripheral vasodilation and clinical characteristics in patients with chronic heart failure. Am Heart J 128:1164–1169PubMed

go back to reference Zelis R, Sinoway LI, Musch TL et al (1988) Regional blood flow in congestive heart failure: concept of compensatory mechanisms with short and long time constants. Am J Cardiol 62:2E–8EPubMed Zelis R, Sinoway LI, Musch TL et al (1988) Regional blood flow in congestive heart failure: concept of compensatory mechanisms with short and long time constants. Am J Cardiol 62:2E–8EPubMed

go back to reference Le Jemtel T, Padeletti M, Jelic S (2007) Diagnostic and therapeutic challenges in patients with coexistent chronic obstructive pulmonary disease and chronic heart failure. J Am Coll Cardiol 49:171–180PubMed Le Jemtel T, Padeletti M, Jelic S (2007) Diagnostic and therapeutic challenges in patients with coexistent chronic obstructive pulmonary disease and chronic heart failure. J Am Coll Cardiol 49:171–180PubMed

go back to reference Vescovo G, Zennaro R, Sandri M, Carraro U, Leprotti C, Ceconi C, Ambrosio GB, Dalla Libera L (1998) Apoptosis of skeletal muscle myofibers and interstitial cells in experimental heart failure. J Mol Cell Cardiol 30:2449–2459PubMed Vescovo G, Zennaro R, Sandri M, Carraro U, Leprotti C, Ceconi C, Ambrosio GB, Dalla Libera L (1998) Apoptosis of skeletal muscle myofibers and interstitial cells in experimental heart failure. J Mol Cell Cardiol 30:2449–2459PubMed

go back to reference Piepoli MF, Kaczmarek A, Francis DP, Davies LC, Rauchhaus M, Jankowska EA, Anker SC, Capucci A, Banasiak W, Ponikowski P (2006) Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure. Circluation 114(2):126–134 Piepoli MF, Kaczmarek A, Francis DP, Davies LC, Rauchhaus M, Jankowska EA, Anker SC, Capucci A, Banasiak W, Ponikowski P (2006) Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure. Circluation 114(2):126–134

go back to reference Clark AL, Poole-Wilson PA (1996) Exercise limitation in chronic heart failure: central role of periphery. J Am Coll Cardiol 28:1092–1102PubMed Clark AL, Poole-Wilson PA (1996) Exercise limitation in chronic heart failure: central role of periphery. J Am Coll Cardiol 28:1092–1102PubMed

go back to reference Bacurau AV, Jardim MA, Ferreira JC, Bechara LR, Bueno CR Jr, Alba-Loureiro TC, Negrao CE, Casarini DE, Curi R, Ramires PR, Moriscot AS, Brum PC (2009) Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training. J Appl Physiol 106(5):1631–1640 (Epub 2009 Jan 29)PubMed Bacurau AV, Jardim MA, Ferreira JC, Bechara LR, Bueno CR Jr, Alba-Loureiro TC, Negrao CE, Casarini DE, Curi R, Ramires PR, Moriscot AS, Brum PC (2009) Sympathetic hyperactivity differentially affects skeletal muscle mass in developing heart failure: role of exercise training. J Appl Physiol 106(5):1631–1640 (Epub 2009 Jan 29)PubMed

go back to reference Adams V, Nehrhoff B, Späte U, Linke A, Schulze PC, Baur A, Gielen S, Hambrecht R, Schuler G (2002) Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study. Cardiovasc Res 54(1):95–104PubMed Adams V, Nehrhoff B, Späte U, Linke A, Schulze PC, Baur A, Gielen S, Hambrecht R, Schuler G (2002) Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study. Cardiovasc Res 54(1):95–104PubMed

go back to reference Schulze PC, Gielen S, Adams V, Linke A, Möbius-Winkler S, Erbs S, Kratzsch J, Hambrecht R, Schuler G (2003) Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulin like growth factor-I in chronic heart failure. Basic Res Cardiol 98(4):267–274PubMed Schulze PC, Gielen S, Adams V, Linke A, Möbius-Winkler S, Erbs S, Kratzsch J, Hambrecht R, Schuler G (2003) Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulin like growth factor-I in chronic heart failure. Basic Res Cardiol 98(4):267–274PubMed

go back to reference Hambrecht R, Schulze PC, Gielen S, Linke A, Möbius-Winkler S, Yu J, Kratzsch JJ, Baldauf G, Busse MW, Schubert A, Adams V, Schuler G (2002) Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure. J Am Coll Cardiol 39:1175–1181PubMed Hambrecht R, Schulze PC, Gielen S, Linke A, Möbius-Winkler S, Yu J, Kratzsch JJ, Baldauf G, Busse MW, Schubert A, Adams V, Schuler G (2002) Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic patients with chronic heart failure. J Am Coll Cardiol 39:1175–1181PubMed

go back to reference Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, Lin HC, Yancopoulos GD, Glass DJ (2005) Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem 280:2737–2744PubMed Latres E, Amini AR, Amini AA, Griffiths J, Martin FJ, Wei Y, Lin HC, Yancopoulos GD, Glass DJ (2005) Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway. J Biol Chem 280:2737–2744PubMed

go back to reference Schulze PC, Fang J, Kassik KA, Gannon J, Cupesi M, MacGillivray C, Lee RT, Rosenthal N (2005) Transgenic overexpression of locally acting IGF-1 inhibits ubiquitin-mediated muscle atrophy in chronic left ventricular dysfunction. Circ Res 97:418–426PubMed Schulze PC, Fang J, Kassik KA, Gannon J, Cupesi M, MacGillivray C, Lee RT, Rosenthal N (2005) Transgenic overexpression of locally acting IGF-1 inhibits ubiquitin-mediated muscle atrophy in chronic left ventricular dysfunction. Circ Res 97:418–426PubMed

go back to reference Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117:399–412PubMed Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117:399–412PubMed

go back to reference Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE (2004) Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113:115–123PubMed Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE (2004) Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113:115–123PubMed

go back to reference Conraads VM, Hoymans VY, Vermeulen T, Beckers P, Possemiers N, Maeseneer MD, Vrints C, Martinet W (2009) Exercise capacity in chronic heart failure patients is related to active gene transcription in skeletal muscle and not apoptosis. Eur J Cardiovasc Prev Rehabil 16(3):325–332PubMed Conraads VM, Hoymans VY, Vermeulen T, Beckers P, Possemiers N, Maeseneer MD, Vrints C, Martinet W (2009) Exercise capacity in chronic heart failure patients is related to active gene transcription in skeletal muscle and not apoptosis. Eur J Cardiovasc Prev Rehabil 16(3):325–332PubMed

go back to reference Giannuzzi P, Temporelli PL, Corra U, Tavazzi L, ELVD-CHF Study Group (2003) Antiremodelling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) Trial. Circulation 108(5):554–559PubMed Giannuzzi P, Temporelli PL, Corra U, Tavazzi L, ELVD-CHF Study Group (2003) Antiremodelling effect of long-term exercise training in patients with stable chronic heart failure: results of the Exercise in Left Ventricular Dysfunction and Chronic Heart Failure (ELVD-CHF) Trial. Circulation 108(5):554–559PubMed

go back to reference Guazzi M, Reina G, Tumminello G, Guazzi MD (2004) Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure. J Appl Physiol 97(5):1866–1873PubMed Guazzi M, Reina G, Tumminello G, Guazzi MD (2004) Improvement of alveolar-capillary membrane diffusing capacity with exercise training in chronic heart failure. J Appl Physiol 97(5):1866–1873PubMed

go back to reference Piepoli ME (2005) Exercise training in heart failure. Curr Cardiol Reports 7(3):216–222 Piepoli ME (2005) Exercise training in heart failure. Curr Cardiol Reports 7(3):216–222

go back to reference Hornig B, Maier V, Drexler H (1996) Physical training improves endothelial function in patients with chronic heart failure. Circulation 93(2):210–214PubMed Hornig B, Maier V, Drexler H (1996) Physical training improves endothelial function in patients with chronic heart failure. Circulation 93(2):210–214PubMed

go back to reference Hambrecht R, Fiehn E, Yu J, Niebauer J, Weigl C, Hilbrich L, Adams V, Riede U, Schuler G (1997) Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure. J Am Coll Cardiol 29:1067–1073PubMed Hambrecht R, Fiehn E, Yu J, Niebauer J, Weigl C, Hilbrich L, Adams V, Riede U, Schuler G (1997) Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure. J Am Coll Cardiol 29:1067–1073PubMed

go back to reference Adamopoulos S, Coats AJ, Brunotte F, Arnolda L, Meyer T, Thompson CH, Dunn JF, Stratton J, Kemp GJ, Radda GK, Sleight P, Rajagopalan B (1993) Physical training improves skeletal muscle metabolism in patients with chronic heart failure. J Am Coll Cardiol 21(5):1101–1106PubMed Adamopoulos S, Coats AJ, Brunotte F, Arnolda L, Meyer T, Thompson CH, Dunn JF, Stratton J, Kemp GJ, Radda GK, Sleight P, Rajagopalan B (1993) Physical training improves skeletal muscle metabolism in patients with chronic heart failure. J Am Coll Cardiol 21(5):1101–1106PubMed

go back to reference Schulze PC, Gielen S, Schuler G, Hambrecht R (2002) Chronic heart failure and skeletal muscle catabolism: effects of exercise training. Int J Cardiol 85(1):141–149PubMed Schulze PC, Gielen S, Schuler G, Hambrecht R (2002) Chronic heart failure and skeletal muscle catabolism: effects of exercise training. Int J Cardiol 85(1):141–149PubMed

go back to reference Piepoli M, Clark AL, Volterrani M, Adamopoulos S, Sleight P, Coats AJ (1996) Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training. Circulation 93(5):940–952PubMed Piepoli M, Clark AL, Volterrani M, Adamopoulos S, Sleight P, Coats AJ (1996) Contribution of muscle afferents to the hemodynamic, autonomic, and ventilatory responses to exercise in patients with chronic heart failure: effects of physical training. Circulation 93(5):940–952PubMed

go back to reference Roveda F, Middlekauff HR, Rondon MU et al (2003) The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. JACC 42(5):854–860PubMed Roveda F, Middlekauff HR, Rondon MU et al (2003) The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. JACC 42(5):854–860PubMed

go back to reference Coats AJS, Adamopoulos S, Radaelli A, McCance A, Meyer TE, Bernardi L, Solda PL, Davey P, Ormerod O, Forfar C, Conway J, Sleight P (1992) Controlled trial of physical training in chronic heart failure: exercise performance, hemodynamics, ventilation and autonomic function. Circulation 85:2119–2131PubMed Coats AJS, Adamopoulos S, Radaelli A, McCance A, Meyer TE, Bernardi L, Solda PL, Davey P, Ormerod O, Forfar C, Conway J, Sleight P (1992) Controlled trial of physical training in chronic heart failure: exercise performance, hemodynamics, ventilation and autonomic function. Circulation 85:2119–2131PubMed

go back to reference Adamopoulos S, Ponikowski P, Cerquetani E, Piepoli M, Rosano G, Sleight P, Coats AJ (1995) Circadian pattern of heart rate variability in chronic heart failure patients. Effects of physical training. Eur Heart J 16(10):1380–1386PubMed Adamopoulos S, Ponikowski P, Cerquetani E, Piepoli M, Rosano G, Sleight P, Coats AJ (1995) Circadian pattern of heart rate variability in chronic heart failure patients. Effects of physical training. Eur Heart J 16(10):1380–1386PubMed

go back to reference Myers J, Hadley D, Oswald U et al (2007) Effects of exercise training on heart rate recovery in patients with chronic heart failure. Am Heart J 153(6):1056–1063PubMed Myers J, Hadley D, Oswald U et al (2007) Effects of exercise training on heart rate recovery in patients with chronic heart failure. Am Heart J 153(6):1056–1063PubMed

go back to reference Liu JL, Kulakofsky J, Zucker IH (2002) Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure. J Appl Physiol 92(6):2403–2408PubMed Liu JL, Kulakofsky J, Zucker IH (2002) Exercise training enhances baroreflex control of heart rate by a vagal mechanism in rabbits with heart failure. J Appl Physiol 92(6):2403–2408PubMed

go back to reference Gao L, Wang W, Liu D, Zucker IH (2007) Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure. Circulation 115(24):3095–3102PubMed Gao L, Wang W, Liu D, Zucker IH (2007) Exercise training normalizes sympathetic outflow by central antioxidant mechanisms in rabbits with pacing-induced chronic heart failure. Circulation 115(24):3095–3102PubMed

go back to reference Passino C, Severino S, Poletti R, Piepoli MF, Mammini C, Clerico A, Gabutti A, Nassi G, Emdin M (2006) Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure. JACC 47(9):1835–1839PubMed Passino C, Severino S, Poletti R, Piepoli MF, Mammini C, Clerico A, Gabutti A, Nassi G, Emdin M (2006) Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure. JACC 47(9):1835–1839PubMed

go back to reference Adamopoulos S, Parissis J, Karatzas D, Kroupis C, Georgiadis M, Karavolias D, Paraskevaidis J, Koniavitou K, Koats AJ, Kremastinos DT (2002) Physical training modulates proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure. J Am Coll Cardiol 39:653–663PubMed Adamopoulos S, Parissis J, Karatzas D, Kroupis C, Georgiadis M, Karavolias D, Paraskevaidis J, Koniavitou K, Koats AJ, Kremastinos DT (2002) Physical training modulates proinflammatory cytokines and soluble Fas/soluble Fas ligand system in patients with chronic heart failure. J Am Coll Cardiol 39:653–663PubMed

go back to reference Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, Kempf W, Schubert A, Schuler G, Hambrecht R (2003) Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol 42:861–868PubMed Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, Kempf W, Schubert A, Schuler G, Hambrecht R (2003) Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol 42:861–868PubMed

go back to reference Linke A, Adams V, Schulze PC et al (2005) Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. Circulation 111(14):1763–1770PubMed Linke A, Adams V, Schulze PC et al (2005) Antioxidative effects of exercise training in patients with chronic heart failure: increase in radical scavenger enzyme activity in skeletal muscle. Circulation 111(14):1763–1770PubMed

go back to reference Gielen S, Adams V, Linke A, Erbs S, Möbius-Winkler S, Schubert A, Schuler G, Hambrecht R (2005) Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. Eur J Cardiovasc Prev Rehabil 12(4):393–400PubMed Gielen S, Adams V, Linke A, Erbs S, Möbius-Winkler S, Schubert A, Schuler G, Hambrecht R (2005) Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. Eur J Cardiovasc Prev Rehabil 12(4):393–400PubMed

go back to reference Maiorana A, O’Driscoll G, Dembo L, Cheetham C, Goodman C, Taylor R, Green D (2000) Effect of aerobic and resistance exercise training on vascular function in heart failure. Am J Physiol Heart Circ Physiol 279(4):H1999–H2005PubMed Maiorana A, O’Driscoll G, Dembo L, Cheetham C, Goodman C, Taylor R, Green D (2000) Effect of aerobic and resistance exercise training on vascular function in heart failure. Am J Physiol Heart Circ Physiol 279(4):H1999–H2005PubMed

go back to reference Laufs U, Werner N, Link A et al (2004) Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109(2):220–226PubMed Laufs U, Werner N, Link A et al (2004) Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 109(2):220–226PubMed

go back to reference Sarto P, Balducci E, Balconi G, Fiordaliso F, Merlo L, Tuzzato G, Pappagallo GL, Frigato N, Zanocco A, Forestieri C, Azzarello G, Mazzucco A, Valenti MT, Alborino F, Noventa D, Vinante O, Pascotto P, Sartore S, Dejana E, Latini R (2007) Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. J Card Fail 13(9):701–708PubMed Sarto P, Balducci E, Balconi G, Fiordaliso F, Merlo L, Tuzzato G, Pappagallo GL, Frigato N, Zanocco A, Forestieri C, Azzarello G, Mazzucco A, Valenti MT, Alborino F, Noventa D, Vinante O, Pascotto P, Sartore S, Dejana E, Latini R (2007) Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. J Card Fail 13(9):701–708PubMed

go back to reference Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, Yu J, Adams V, Niebauer J, Schuler G (1998) Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 98(24):2709–2715PubMed Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, Yu J, Adams V, Niebauer J, Schuler G (1998) Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 98(24):2709–2715PubMed

go back to reference You Fang Z, Marwick T (2003) Mechanisms of exercise training in patients with heart failure. Am Heart J 145:904–911PubMed You Fang Z, Marwick T (2003) Mechanisms of exercise training in patients with heart failure. Am Heart J 145:904–911PubMed

go back to reference Pu CT, Johnson MT, Forman DE, Hausdorff JM, Roubenoff R, Foldvari M, Fielding RA, Singh MA (2001) Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure. J Appl Physiol 90:2341–2350PubMed Pu CT, Johnson MT, Forman DE, Hausdorff JM, Roubenoff R, Foldvari M, Fielding RA, Singh MA (2001) Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure. J Appl Physiol 90:2341–2350PubMed

go back to reference Beckers PJ, Denollet J, Possemiers NM, Wuyts FL, Vrints CJ, Conraads VM (2008) Combined endurance-resistance training vs. endurance training in patients with chronic heart failure: a prospective randomized study. Eur Heart J 29(15):1858–1866PubMed Beckers PJ, Denollet J, Possemiers NM, Wuyts FL, Vrints CJ, Conraads VM (2008) Combined endurance-resistance training vs. endurance training in patients with chronic heart failure: a prospective randomized study. Eur Heart J 29(15):1858–1866PubMed

go back to reference Larsen AI, Lindal S, Aukrust P, Toft I, Aarsland T, Dickstein K (2002) Effect of exercise training on skeletal muscle fibre characteristics in men with chronic heart failure. Correlation between skeletal muscle alterations, cytokines and exercise capacity. Int J Cardiol 83(1):25–32PubMed Larsen AI, Lindal S, Aukrust P, Toft I, Aarsland T, Dickstein K (2002) Effect of exercise training on skeletal muscle fibre characteristics in men with chronic heart failure. Correlation between skeletal muscle alterations, cytokines and exercise capacity. Int J Cardiol 83(1):25–32PubMed

go back to reference Sullivan MJ, Higginbotham MB, Cobb FR (1988) Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects. Circulation 78(3):506–515PubMed Sullivan MJ, Higginbotham MB, Cobb FR (1988) Exercise training in patients with severe left ventricular dysfunction. Hemodynamic and metabolic effects. Circulation 78(3):506–515PubMed

go back to reference Hambrecht R, Niebauer J, Fiehn E, Kälberer B, Offner B, Hauer K, Riede U, Schlierf G, Kübler W, Schuler G (1995) Physical training in patients with stable chronic heart failure: effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. J Am Coll Cardiol 25(6):1239–1249PubMed Hambrecht R, Niebauer J, Fiehn E, Kälberer B, Offner B, Hauer K, Riede U, Schlierf G, Kübler W, Schuler G (1995) Physical training in patients with stable chronic heart failure: effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. J Am Coll Cardiol 25(6):1239–1249PubMed

go back to reference Brunotte F, Thompson CH, Adamopoulos S, Coats A, Unitt J, Lindsay D, Kaklamanis L, Radda GK, Rajagopalan B (1995) Rat skeletal muscle metabolism in experimental heart failure: effects of physical training. Acta Physiol Scand 154(4):439–447PubMed Brunotte F, Thompson CH, Adamopoulos S, Coats A, Unitt J, Lindsay D, Kaklamanis L, Radda GK, Rajagopalan B (1995) Rat skeletal muscle metabolism in experimental heart failure: effects of physical training. Acta Physiol Scand 154(4):439–447PubMed

go back to reference Ventura-Clapier R, Mettauer B, Bigard X (2007) Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure. Cardiovasc Res 73(1):10–18PubMed Ventura-Clapier R, Mettauer B, Bigard X (2007) Beneficial effects of endurance training on cardiac and skeletal muscle energy metabolism in heart failure. Cardiovasc Res 73(1):10–18PubMed

go back to reference Garnier A, Fortin D, Delomenie C, Momken I, Veksler V, Ventura-Clapier R (2003) Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 551:491–501PubMed Garnier A, Fortin D, Delomenie C, Momken I, Veksler V, Ventura-Clapier R (2003) Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol 551:491–501PubMed

go back to reference Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115(24):3086–3094PubMed Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T (2007) Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation 115(24):3086–3094PubMed

go back to reference Keteyian SJ, Levine AB, Brawner CA, Kataoka T, Rogers FJ, Schairer JR, Stein PD, Levine TB, Goldstein S (1996) Exercise training in patients with heart failure: a randomized, controlled trial. Ann Int Med 124:1051–1057PubMed Keteyian SJ, Levine AB, Brawner CA, Kataoka T, Rogers FJ, Schairer JR, Stein PD, Levine TB, Goldstein S (1996) Exercise training in patients with heart failure: a randomized, controlled trial. Ann Int Med 124:1051–1057PubMed

go back to reference Dubach P, Myers J, Dziekan G, Goebbels U, Reinhart W, Muller P, Buser P, Stulz P, Vogt P, Ratti R (1997) The effect of high intensity exercise training on central hemodynamic response to exercise in men with reduced left ventricular function. J Am Coll Cardiol 29:1591–1598PubMed Dubach P, Myers J, Dziekan G, Goebbels U, Reinhart W, Muller P, Buser P, Stulz P, Vogt P, Ratti R (1997) The effect of high intensity exercise training on central hemodynamic response to exercise in men with reduced left ventricular function. J Am Coll Cardiol 29:1591–1598PubMed

go back to reference Belardinelli R, Georgiou D, Cianci G, Purcaro A (1999) Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 99(9):1173–1182PubMed Belardinelli R, Georgiou D, Cianci G, Purcaro A (1999) Randomized, controlled trial of long-term moderate exercise training in chronic heart failure: effects on functional capacity, quality of life, and clinical outcome. Circulation 99(9):1173–1182PubMed

go back to reference Beer M, Wagner D, Myers J, Sandstede J, Köstler H, Hahn D, Neubauer S, Dubach P (2008) Effects of exercise training on myocardial energy metabolism and ventricular function assessed by quantitative phosphorus-31 magnetic resonance spectroscopy and magnetic resonance imaging in dilated cardiomyopathy. J Am Coll Cardiol 51(19):1883–1891PubMed Beer M, Wagner D, Myers J, Sandstede J, Köstler H, Hahn D, Neubauer S, Dubach P (2008) Effects of exercise training on myocardial energy metabolism and ventricular function assessed by quantitative phosphorus-31 magnetic resonance spectroscopy and magnetic resonance imaging in dilated cardiomyopathy. J Am Coll Cardiol 51(19):1883–1891PubMed

go back to reference European Heart Failure Training Group (1998) Experience from controlled trials of physical training in chronic heart failure. Protocol and patient factors in effectiveness in the improvement in exercise tolerance. Eur Heart J 19(3):466–475 European Heart Failure Training Group (1998) Experience from controlled trials of physical training in chronic heart failure. Protocol and patient factors in effectiveness in the improvement in exercise tolerance. Eur Heart J 19(3):466–475

go back to reference Piepoli MF, Davos C, Francis DP, Coats AJS, ExTraMATCH Collaborative (2004) Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 328:189–198PubMed Piepoli MF, Davos C, Francis DP, Coats AJS, ExTraMATCH Collaborative (2004) Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 328:189–198PubMed

go back to reference O’Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Piña IL, HF-ACTION Investigators (2009) Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301(14):1439–1450PubMed O’Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Piña IL, HF-ACTION Investigators (2009) Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 301(14):1439–1450PubMed

go back to reference Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Strömberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Tendera M, Auricchio A, Bax J, Böhm M, Corrà U, della Bella P, Elliott PM, Follath F, Gheorghiade M, Hasin Y, Hernborg A, Jaarsma T, Komajda M, Kornowski R, Piepoli M, Prendergast B, Tavazzi L, Vachiery JL, Verheugt FW, Zamorano JL, Zannad F (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 10(10):933–989 Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Strömberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Tendera M, Auricchio A, Bax J, Böhm M, Corrà U, della Bella P, Elliott PM, Follath F, Gheorghiade M, Hasin Y, Hernborg A, Jaarsma T, Komajda M, Kornowski R, Piepoli M, Prendergast B, Tavazzi L, Vachiery JL, Verheugt FW, Zamorano JL, Zannad F (2008) ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur Heart J 10(10):933–989

go back to reference Roy RR, Meadows ID, Baldwin KM, Edgerton VR (1982) Functional significance of compensatory overloaded rat fast muscle. J Appl Physiol 52:473–478PubMed Roy RR, Meadows ID, Baldwin KM, Edgerton VR (1982) Functional significance of compensatory overloaded rat fast muscle. J Appl Physiol 52:473–478PubMed

go back to reference Buller AJ, Eccles JC, Eccles RM (1960) Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses. J Physiol 150:417–439PubMed Buller AJ, Eccles JC, Eccles RM (1960) Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses. J Physiol 150:417–439PubMed

go back to reference Kanno S, Oda N, Abe M, Saito S, Hori K, Handa Y, Tabayashi K, Sato Y (1999) Establishment of a simple and practical procedure applicable to therapeutic angiogenesis. Circulation 99:2682–2687PubMed Kanno S, Oda N, Abe M, Saito S, Hori K, Handa Y, Tabayashi K, Sato Y (1999) Establishment of a simple and practical procedure applicable to therapeutic angiogenesis. Circulation 99:2682–2687PubMed

go back to reference Annex BH, Torgan CE, Lin P, Taylor DA, Thompson MA, Peters KG, Kraus WE (1998) Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle. Am J Physiol 274:H860–H867PubMed Annex BH, Torgan CE, Lin P, Taylor DA, Thompson MA, Peters KG, Kraus WE (1998) Induction and maintenance of increased VEGF protein by chronic motor nerve stimulation in skeletal muscle. Am J Physiol 274:H860–H867PubMed

go back to reference Pette D, Vrbová G (1999) What does chronic electrical stimulation teach us about muscle plasticity? Muscle Nerve 22:666–677 (Review)PubMed Pette D, Vrbová G (1999) What does chronic electrical stimulation teach us about muscle plasticity? Muscle Nerve 22:666–677 (Review)PubMed

go back to reference Browson C, Isenberg H, Brown W, Salmons S, Edwards Y (1988) Changes in skeletal muscle gene transcription induced by chronic stimulation. Muscle Nerve 11:1183–1189 Browson C, Isenberg H, Brown W, Salmons S, Edwards Y (1988) Changes in skeletal muscle gene transcription induced by chronic stimulation. Muscle Nerve 11:1183–1189

go back to reference Williams RS, Garcia-Moll M, Mellor J, Salmons S, Harlan W (1987) Adaptation of skeletal muscle to increase contractile activity. Expression of nuclear genes encoding mitochondrial proteins. J Biol Chem 262:2764–2767PubMed Williams RS, Garcia-Moll M, Mellor J, Salmons S, Harlan W (1987) Adaptation of skeletal muscle to increase contractile activity. Expression of nuclear genes encoding mitochondrial proteins. J Biol Chem 262:2764–2767PubMed

go back to reference Heilmann C, Muller W, Pette D (1981) Correlation between ultrastructural and functional changes in sarcoplasmic reticulum during chronic stimulation of fast muscle. J Membrane Biol 59:143–149 Heilmann C, Muller W, Pette D (1981) Correlation between ultrastructural and functional changes in sarcoplasmic reticulum during chronic stimulation of fast muscle. J Membrane Biol 59:143–149

go back to reference Hudlická O, Dodd L, Renkin EM, Gray SD (1982) Early changes in fiber profile and capillary density in long-term stimulated muscles. Am J Physiol 243:H528–H535PubMed Hudlická O, Dodd L, Renkin EM, Gray SD (1982) Early changes in fiber profile and capillary density in long-term stimulated muscles. Am J Physiol 243:H528–H535PubMed

go back to reference Salmons S, Gale DR, Sreter FA (1978) Ultrastructural aspects of the transformation of muscle fibre type by long-term stimulation: changes in Z discs and mitochondria. J Anat 127:17–31PubMed Salmons S, Gale DR, Sreter FA (1978) Ultrastructural aspects of the transformation of muscle fibre type by long-term stimulation: changes in Z discs and mitochondria. J Anat 127:17–31PubMed

go back to reference Salmons S, Sreter FA (1976) Significance of impulse activity in the transformation of skeletal muscle type. Nature 263:30–34PubMed Salmons S, Sreter FA (1976) Significance of impulse activity in the transformation of skeletal muscle type. Nature 263:30–34PubMed

go back to reference Gordon T, Mao J (1994) Muscle atrophy and procedures for training after spinal cord injury. Phys Ther 74:50–60 (Review)PubMed Gordon T, Mao J (1994) Muscle atrophy and procedures for training after spinal cord injury. Phys Ther 74:50–60 (Review)PubMed

go back to reference Jacobs PL, Nash MS (2001) Modes, benefits and risks of voluntary and electrically induced exercise in persons with spinal cord injury. J Spinal Cord Med 24:10–18 (Review)PubMed Jacobs PL, Nash MS (2001) Modes, benefits and risks of voluntary and electrically induced exercise in persons with spinal cord injury. J Spinal Cord Med 24:10–18 (Review)PubMed

go back to reference Hillegass EA, Dudley CA (1999) Surface electrical stimulation of skeletal muscle after spinal cord injury. Spinal Cord 37:251–257PubMed Hillegass EA, Dudley CA (1999) Surface electrical stimulation of skeletal muscle after spinal cord injury. Spinal Cord 37:251–257PubMed

go back to reference Scremin AM, Kurta L, Gentili A, Wiseman B, Perell K, Krunkel C, Scremin OU (1999) Increasing muscle mass in spinal cord injured persons with a functional electrical stimulation exercise programme. Arch Phys Med Rehabil 80:1531–1536PubMed Scremin AM, Kurta L, Gentili A, Wiseman B, Perell K, Krunkel C, Scremin OU (1999) Increasing muscle mass in spinal cord injured persons with a functional electrical stimulation exercise programme. Arch Phys Med Rehabil 80:1531–1536PubMed

go back to reference Arcidsson I, Arcidsson H, Eriksson E, Jansson E (1986) Prevention of quadriceps wasting after immobilization: an evaluation of the effect of electrical stimulation. Orthopedics 9:1519–1528 Arcidsson I, Arcidsson H, Eriksson E, Jansson E (1986) Prevention of quadriceps wasting after immobilization: an evaluation of the effect of electrical stimulation. Orthopedics 9:1519–1528

go back to reference Gibson JN, Morrison WL, Scrimgeour CM, Smith K, Stoward PJ, Rennie MJ (1989) Effects of therapeutic percutaneous electrical stimulation of atrophic human quadriceps on muscle composition, protein synthesis and contractile properties. Eur J Clin Invest 19:206–212PubMed Gibson JN, Morrison WL, Scrimgeour CM, Smith K, Stoward PJ, Rennie MJ (1989) Effects of therapeutic percutaneous electrical stimulation of atrophic human quadriceps on muscle composition, protein synthesis and contractile properties. Eur J Clin Invest 19:206–212PubMed

go back to reference Vinge O, Edvardsen L, Jensen F, Jensen FG, Wernerman J, Kehlet H (1996) Effect of transcutaneous electrical muscle stimulation on postoperative muscle mass and protein synthesis. Br J Surg 83:360–363PubMed Vinge O, Edvardsen L, Jensen F, Jensen FG, Wernerman J, Kehlet H (1996) Effect of transcutaneous electrical muscle stimulation on postoperative muscle mass and protein synthesis. Br J Surg 83:360–363PubMed

go back to reference Lewek M, Stevens J, Snyder-Mackler L (2001) The use of electrical stimulation to increase quadriceps femoris muscle force in an elderly patient following a total knee arthroplasty. Phys Ther 81:1565–1571PubMed Lewek M, Stevens J, Snyder-Mackler L (2001) The use of electrical stimulation to increase quadriceps femoris muscle force in an elderly patient following a total knee arthroplasty. Phys Ther 81:1565–1571PubMed

go back to reference Maillefert JF, Eicher JC, Walker P, Dulieu V, Rouhier-Marcer I, Branly F, Cohen M, Brunotte F, Wolf JE, Casillas JM, Didier JP (1998) Effects of low-frequency electrical stimulation of quadriceps and calf muscles in patients with chronic heart failure. J Cardiopulm Rehabil 18:277–282PubMed Maillefert JF, Eicher JC, Walker P, Dulieu V, Rouhier-Marcer I, Branly F, Cohen M, Brunotte F, Wolf JE, Casillas JM, Didier JP (1998) Effects of low-frequency electrical stimulation of quadriceps and calf muscles in patients with chronic heart failure. J Cardiopulm Rehabil 18:277–282PubMed

go back to reference Vaquero AF, Chicharro JL, Gil L, Ruiz MP, Sánchez V, Lucía A, Urrea S, Gómez MA (1998) Effects of muscle electrical stimulation on peak VO2 in cardiac transplant patients. Int J Sports Med 19:317–322PubMed Vaquero AF, Chicharro JL, Gil L, Ruiz MP, Sánchez V, Lucía A, Urrea S, Gómez MA (1998) Effects of muscle electrical stimulation on peak VO₂ in cardiac transplant patients. Int J Sports Med 19:317–322PubMed

go back to reference Quittan M, Sochor A, Wiesinger G, Kollmitzer J, Sturm B, Pacher R, Mayr W (1999) Strength improvement of knee extensor muscles in patients with chronic heart failure by neuromuscular electrical stimulation. Artif Organs 23(5):432–435PubMed Quittan M, Sochor A, Wiesinger G, Kollmitzer J, Sturm B, Pacher R, Mayr W (1999) Strength improvement of knee extensor muscles in patients with chronic heart failure by neuromuscular electrical stimulation. Artif Organs 23(5):432–435PubMed

go back to reference Quittan M, Wiesinger GF, Sturm B, Puiq S, Mayr W, Sochor A, Paternostro T, Resch KL, Pacher R, Fialka-Moser V (2001) Improvement of thigh muscles by neuromuscular electrical stimulation in patients with refractory heart failure. Am J Phys Med Rehabil 80:206–214PubMed Quittan M, Wiesinger GF, Sturm B, Puiq S, Mayr W, Sochor A, Paternostro T, Resch KL, Pacher R, Fialka-Moser V (2001) Improvement of thigh muscles by neuromuscular electrical stimulation in patients with refractory heart failure. Am J Phys Med Rehabil 80:206–214PubMed

go back to reference Harris S, LeMaitre JP, Machenzie G, Fox KA, Denvir MA (2003) A randomized study of home-based electrical stimulation of the legs and conventional bicycle exercise for patients with chronic heart failure. Eur Heart J 24:871–878PubMed Harris S, LeMaitre JP, Machenzie G, Fox KA, Denvir MA (2003) A randomized study of home-based electrical stimulation of the legs and conventional bicycle exercise for patients with chronic heart failure. Eur Heart J 24:871–878PubMed

go back to reference Nuhr MJ, Pette D, Berger R, Quittan M, Crevenna R, Huelsman M, Wiesinger GF, Moser P, Fialka-Moser V, Pacher R (2004) Beneficial effects of chronic low-frequency stimulation of thigh muscles in patients with advanced chronic heart failure. Eur Heart J 25:136–143PubMed Nuhr MJ, Pette D, Berger R, Quittan M, Crevenna R, Huelsman M, Wiesinger GF, Moser P, Fialka-Moser V, Pacher R (2004) Beneficial effects of chronic low-frequency stimulation of thigh muscles in patients with advanced chronic heart failure. Eur Heart J 25:136–143PubMed

go back to reference Deley G, Kervio G, Verges B, Hannequin A, Petitdant MF, Salmi-Belmihoub S, Grassi B, Casillas JM (2005) Comparison of low-frequency electrical myostimulation and conventional aerobic exercise training in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 12:226–233PubMed Deley G, Kervio G, Verges B, Hannequin A, Petitdant MF, Salmi-Belmihoub S, Grassi B, Casillas JM (2005) Comparison of low-frequency electrical myostimulation and conventional aerobic exercise training in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 12:226–233PubMed

go back to reference Dobsák P, Nováková M, Siegelová J, Fiser B, Vítovec J, Naqasaka M, Kohzuki M, Yambe T, Nitta S, Eicher JC, Wolf JE, Imachi K (2006) Low-frequency electrical stimulation increases muscle strength and improves blood supply in patients with chronic heart failure. Circ J 70:75–82PubMed Dobsák P, Nováková M, Siegelová J, Fiser B, Vítovec J, Naqasaka M, Kohzuki M, Yambe T, Nitta S, Eicher JC, Wolf JE, Imachi K (2006) Low-frequency electrical stimulation increases muscle strength and improves blood supply in patients with chronic heart failure. Circ J 70:75–82PubMed

go back to reference Dobsák P, Nováková M, Fiser B, Siegelová J, Balcárková P, Spinarová L, Vítovec J, Minami N, Naqasaka M, Kohzuki M, Yambe T, Imachi K, Nitta S, Eicher JC, Wolf JE (2005) Electrical stimulation of skeletal muscles. An alternative to aerobic exercise training in patients with chronic heart failure. Int Heart J 47(3):441–453 Dobsák P, Nováková M, Fiser B, Siegelová J, Balcárková P, Spinarová L, Vítovec J, Minami N, Naqasaka M, Kohzuki M, Yambe T, Imachi K, Nitta S, Eicher JC, Wolf JE (2005) Electrical stimulation of skeletal muscles. An alternative to aerobic exercise training in patients with chronic heart failure. Int Heart J 47(3):441–453

go back to reference Karavidas AI, Raisakis KG, Parissis JT, Tsekoura DK, Adamopoulos S, Korres DA, Farmakis D, Zacharoulis A, Fotiadis I, Matsakas E, Zacharoulis A (2006) Functional electrical stimulation improves endothelial function and reduces peripheral immune responses in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 13:592–597PubMed Karavidas AI, Raisakis KG, Parissis JT, Tsekoura DK, Adamopoulos S, Korres DA, Farmakis D, Zacharoulis A, Fotiadis I, Matsakas E, Zacharoulis A (2006) Functional electrical stimulation improves endothelial function and reduces peripheral immune responses in patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 13:592–597PubMed

go back to reference Karavidas A, Parissis J, Arapi S, Farmakis D, Korres D, Nikolaou M, Fotiadis J, Potamitis N, Driva X, Paraskevaidis I, Matsakas E, Filippatos G, Kremastinos DT (2008) Effects of functional electrical stimulation on quality of life and emotional stress in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy: a randomized, placebo-controlled trial. Eur J Heart Failure 10(7):709–713 Karavidas A, Parissis J, Arapi S, Farmakis D, Korres D, Nikolaou M, Fotiadis J, Potamitis N, Driva X, Paraskevaidis I, Matsakas E, Filippatos G, Kremastinos DT (2008) Effects of functional electrical stimulation on quality of life and emotional stress in patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy: a randomized, placebo-controlled trial. Eur J Heart Failure 10(7):709–713

go back to reference Banerjee P, Caulfield B, Crowe L, Clark A (2009) Prolonged electrical muscle stimulation exercise improves strength, peak VO2 and exercise capacity in patients with stable chronic heart failure. J Card Fail 15(4):319–326PubMed Banerjee P, Caulfield B, Crowe L, Clark A (2009) Prolonged electrical muscle stimulation exercise improves strength, peak VO₂ and exercise capacity in patients with stable chronic heart failure. J Card Fail 15(4):319–326PubMed

go back to reference Karavidas A, Parissis J, Matzaraki V, Arapi S, Varounis C, Ikonomidis I, Grillias P, Paraskevaidis I, Pyrgakis V, Filippatos G, Kremastinos D (2010) Functional electrical stimulation is more effective in severe symptomatic heart failure patients and improves their adherence to rehabilitation programs. J Card Fail 16:244–249PubMed Karavidas A, Parissis J, Matzaraki V, Arapi S, Varounis C, Ikonomidis I, Grillias P, Paraskevaidis I, Pyrgakis V, Filippatos G, Kremastinos D (2010) Functional electrical stimulation is more effective in severe symptomatic heart failure patients and improves their adherence to rehabilitation programs. J Card Fail 16:244–249PubMed

go back to reference Wiesinger GF, Crevenna R, Nuhr MJ, Huelsmann M, Fialka-Moser V, Quittan M (2001) Neuromuscular electric stimulation in heart transplantation candidates with cardiac pacemakers. Arch Phys Med Rehabill 82(10):1476–1477 Wiesinger GF, Crevenna R, Nuhr MJ, Huelsmann M, Fialka-Moser V, Quittan M (2001) Neuromuscular electric stimulation in heart transplantation candidates with cardiac pacemakers. Arch Phys Med Rehabill 82(10):1476–1477

go back to reference Crevenna R, Mayr W, Keilani M, Pleiner J, Nuhr M, Quittan M, Pacher R, Fialka-Moser V, Woltz M (2003) Safety of a combined strength and endurance training using neuromuscular electrical stimulation of thigh muscles in patients with heart failure and bipolar sensing cardiac pacemakers. Wien Klin Wochenschr 115(19–20):710–714PubMed Crevenna R, Mayr W, Keilani M, Pleiner J, Nuhr M, Quittan M, Pacher R, Fialka-Moser V, Woltz M (2003) Safety of a combined strength and endurance training using neuromuscular electrical stimulation of thigh muscles in patients with heart failure and bipolar sensing cardiac pacemakers. Wien Klin Wochenschr 115(19–20):710–714PubMed

go back to reference Crevenna R, Wolzt M, Fialka-Moser V, Keilani M, Nuhr M, Paternostra-Sluga T, Pacher R, Mayr W, Quittan M (2004) Long-term transcutaneous neuromuscular electrical stimulation in patients with bipolar sensing implantable cardioverter defibrillators: a pilot safety study. Artif Organs 28(1):99–102PubMed Crevenna R, Wolzt M, Fialka-Moser V, Keilani M, Nuhr M, Paternostra-Sluga T, Pacher R, Mayr W, Quittan M (2004) Long-term transcutaneous neuromuscular electrical stimulation in patients with bipolar sensing implantable cardioverter defibrillators: a pilot safety study. Artif Organs 28(1):99–102PubMed