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Open Access 01-12-2020 | Research article

Functional connectivity and quality of life in young adults with cerebral palsy: a feasibility study

Authors: Diana Tajik-Parvinchi, Andrew Davis, Sophia Roth, Peter Rosenbaum, Sarah N. Hopmans, Aya Dudin, Geoffrey Hall, Jan Willem Gorter, MyStory Study Group

Published in: BMC Neurology | Issue 1/2020

Abstract

Background

Cerebral Palsy (CP) is a group of disorders that affect the development of movement and posture. CP results from injuries to the immature brain during the prenatal, perinatal, or postnatal stage of development. Neuroimaging research in CP has focused on the structural changes of the brain during early development, but little is known about brain’s structural and functional changes during late adolescence and early adulthood, a period in time when individuals experience major changes as they transition into adulthood. The work reported here served as a feasibility study within a larger program of research (MyStory Study). We aimed to determine whether it would be feasible to scan and obtain good quality data without the use of sedation during a resting state condition for functional connectivity (FC) analyses in young adults with CP. Second, we aimed to identify the FC pattern(s) that are associated with depressive mood ratings, indices of pain and fatigue, and quality of life in this group.

Methods

Resting state functional images were collected from 9 young people with CP (18–29 years). We applied a stringent head motion correction and quality control methods following preprocessing.

Results

We were able to scan and obtain good quality data without the use of sedation from this group of young individuals with CP who demonstrated a range of gross motor ability. The functional connectivity networks of interest were identified in the data using standard seed regions. Our analyses further revealed that higher well-being scores were associated with higher levels of FC between the Medial Pre-Frontal Cortex and the right Lateral Parietal regions, which are implicated in prosocial and emotion regulations skills. The implications of this association are discussed.

Conclusion

The findings of the present study demonstrate that it is feasible to conduct resting state functional connectivity in young adults with CP with different gross motor abilities without the use of sedation. Our results also highlight a neural circuitry that is associated with the self-report of quality of life and emotion regulation. These findings identify these regions/circuitries as important seeds for further investigations into mental health and wellbeing in CP.

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Title: Functional connectivity and quality of life in young adults with cerebral palsy: a feasibility study
Authors: Diana Tajik-Parvinchi
Andrew Davis
Sophia Roth
Peter Rosenbaum
Sarah N. Hopmans
Aya Dudin
Geoffrey Hall
Jan Willem Gorter
MyStory Study Group
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-01950-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Functional connectivity and quality of life in young adults with cerebral palsy: a feasibility study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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