Published in:
Open Access
01-05-2014 | Poster presentation
Functional characterization of HIV-1 Tat exon-1 variants from North India and their implications on HIV-1 transactivation and TAR interaction
Authors:
Larance Ronsard, VG Ramachandran, Akhil C Banerjea
Published in:
BMC Infectious Diseases
|
Special Issue 3/2014
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Excerpt
HIV-1 virus is a rapidly evolving virus due to genetic variability through its rapid replication, mutation and recombination potential which is a major hurdle in vaccine development. One of the effective ways to modulate HIV-1 infection is to target viral proteins; among the viral proteins, Tat plays a major role in HIV-1 pathogenesis. It activates viral gene expression through TAR interaction. The aim of this study was to characterize genetic and functional variants of Tat exon-1 from HIV-1 patients from North India. …