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Published in: Malaria Journal 1/2013

Open Access 01-12-2013 | Commentary

Fulani show decreased susceptibility to Plasmodium falciparum infection versus Mossi: data from a community-wide screening and treatment of asymptomatic carriers in Burkina Faso

Authors: Alfred B Tiono, Sodiomon B Sirima, Kamal Hamed

Published in: Malaria Journal | Issue 1/2013

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Abstract

Background

The Fulani ethnic group is known to have a lower susceptibility to Plasmodium falciparum infection than the Mossi.

Methods

This commentary describes data from a recent cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of P. falciparum in 18 villages in Saponé, Burkina Faso.

Results

The Fulani groups had a lower proportion of asymptomatic carriers at any occasion, a lower density of asexual forms and gametocytes of P. falciparum at baseline, and, in children under five years of age, lower rates of symptomatic malaria episodes per person-year than the Mossi.

Discussion and conclusion

These data confirm previously reported differences in P. falciparum susceptibility between Fulani and Mossi.
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Literature
1.
go back to reference Modiano D, Petrarca V, Sirima BS, Bosman A, Nebie I, Diallo D, Lamizana L, Esposito F, Coluzzi M: Plasmodium falciparum malaria in sympatric ethnic groups of Burkina Faso, west Africa. Parassitologia. 1995, 37: 255-259.PubMed Modiano D, Petrarca V, Sirima BS, Bosman A, Nebie I, Diallo D, Lamizana L, Esposito F, Coluzzi M: Plasmodium falciparum malaria in sympatric ethnic groups of Burkina Faso, west Africa. Parassitologia. 1995, 37: 255-259.PubMed
2.
go back to reference Modiano D, Petrarca V, Sirima BS, Nebie I, Diallo D, Esposito F, Coluzzi M: Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups. Proc Natl Acad Sci USA. 1996, 93: 13206-13211. 10.1073/pnas.93.23.13206.PubMedCentralCrossRefPubMed Modiano D, Petrarca V, Sirima BS, Nebie I, Diallo D, Esposito F, Coluzzi M: Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups. Proc Natl Acad Sci USA. 1996, 93: 13206-13211. 10.1073/pnas.93.23.13206.PubMedCentralCrossRefPubMed
3.
go back to reference Modiano D, Chiucchiuini A, Petrarca V, Sirima BS, Luoni G, Perlmann H, Esposito F, Coluzzi M: Humoral response to Plasmodium falciparum Pf155/ring-infected erythrocyte surface antigen and Pf332 in three sympatric ethnic groups of Burkina Faso. AmJTrop Med Hyg. 1998, 58: 220-224. Modiano D, Chiucchiuini A, Petrarca V, Sirima BS, Luoni G, Perlmann H, Esposito F, Coluzzi M: Humoral response to Plasmodium falciparum Pf155/ring-infected erythrocyte surface antigen and Pf332 in three sympatric ethnic groups of Burkina Faso. AmJTrop Med Hyg. 1998, 58: 220-224.
4.
go back to reference Torcia MG, Santarlasci V, Cosmi L, Clemente A, Maggi L, Mangano VD, Verra F, Bancone G, Nebie I, Sirima BS, Liotta F, Frosali F, Angeli R, Severini C, Sannella AR, Bonini P, Lucibello M, Maggi E, Garaci E, Coluzzi M, Cozzolino F, Annunziato F, Romagnani S, Modiano D: Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria. Proc Natl Acad Sci USA. 2008, 105: 646-651. 10.1073/pnas.0709969105.PubMedCentralCrossRefPubMed Torcia MG, Santarlasci V, Cosmi L, Clemente A, Maggi L, Mangano VD, Verra F, Bancone G, Nebie I, Sirima BS, Liotta F, Frosali F, Angeli R, Severini C, Sannella AR, Bonini P, Lucibello M, Maggi E, Garaci E, Coluzzi M, Cozzolino F, Annunziato F, Romagnani S, Modiano D: Functional deficit of T regulatory cells in Fulani, an ethnic group with low susceptibility to Plasmodium falciparum malaria. Proc Natl Acad Sci USA. 2008, 105: 646-651. 10.1073/pnas.0709969105.PubMedCentralCrossRefPubMed
5.
go back to reference Lokki AI, Jarvela I, Israelsson E, Maiga B, Troye-Blomberg M, Dolo A, Doumbo OK, Meri S, Holmberg V: Lactase persistence genotypes and malaria susceptibility in Fulani of Mali. Malar J. 2011, 10: 9-10.1186/1475-2875-10-9.PubMedCentralCrossRefPubMed Lokki AI, Jarvela I, Israelsson E, Maiga B, Troye-Blomberg M, Dolo A, Doumbo OK, Meri S, Holmberg V: Lactase persistence genotypes and malaria susceptibility in Fulani of Mali. Malar J. 2011, 10: 9-10.1186/1475-2875-10-9.PubMedCentralCrossRefPubMed
6.
go back to reference Tiono AB, Ouedraogo A, Ogutu B, Diarra A, Coulibaly B, Gansane A, Sirima SB, O’Neil G, Mukhopadhyay A, Hamed K: A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso. Malar J. 2013, 12: 79-10.1186/1475-2875-12-79.PubMedCentralCrossRefPubMed Tiono AB, Ouedraogo A, Ogutu B, Diarra A, Coulibaly B, Gansane A, Sirima SB, O’Neil G, Mukhopadhyay A, Hamed K: A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso. Malar J. 2013, 12: 79-10.1186/1475-2875-12-79.PubMedCentralCrossRefPubMed
7.
go back to reference Modiano D, Luoni G, Sirima BS, Lanfrancotti A, Petrarca V, Cruciani F, Simpore J, Ciminelli BM, Foglietta E, Grisanti P, Bianco I, Modiano G, Coluzzi M: The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes. Trans R Soc Trop Med Hyg. 2001, 95: 149-152. 10.1016/S0035-9203(01)90141-5.CrossRefPubMed Modiano D, Luoni G, Sirima BS, Lanfrancotti A, Petrarca V, Cruciani F, Simpore J, Ciminelli BM, Foglietta E, Grisanti P, Bianco I, Modiano G, Coluzzi M: The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes. Trans R Soc Trop Med Hyg. 2001, 95: 149-152. 10.1016/S0035-9203(01)90141-5.CrossRefPubMed
8.
go back to reference Farouk SE, Dolo A, Bereczky S, Kouriba B, Maiga B, Farnert A, Perlmann H, Hayano M, Montgomery SM, Doumbo OK, Troye-Blomberg M: Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali. Microbes Infect. 2005, 7: 110-117. 10.1016/j.micinf.2004.09.012.CrossRefPubMed Farouk SE, Dolo A, Bereczky S, Kouriba B, Maiga B, Farnert A, Perlmann H, Hayano M, Montgomery SM, Doumbo OK, Troye-Blomberg M: Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali. Microbes Infect. 2005, 7: 110-117. 10.1016/j.micinf.2004.09.012.CrossRefPubMed
9.
go back to reference Israelsson E, Vafa M, Maiga B, Lysen A, Iriemenam NC, Dolo A, Doumbo OK, Troye-Blomberg M, Berzins K: Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali. Malar J. 2008, 7: 175-10.1186/1475-2875-7-175.PubMedCentralCrossRefPubMed Israelsson E, Vafa M, Maiga B, Lysen A, Iriemenam NC, Dolo A, Doumbo OK, Troye-Blomberg M, Berzins K: Differences in Fcgamma receptor IIa genotypes and IgG subclass pattern of anti-malarial antibodies between sympatric ethnic groups in Mali. Malar J. 2008, 7: 175-10.1186/1475-2875-7-175.PubMedCentralCrossRefPubMed
10.
go back to reference Nasr A, Iriemenam NC, Giha HA, Balogun HA, Anders RF, Troye-Blomberg M, Elghazali G, Berzins K: FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan. Malar J. 2009, 8: 43-10.1186/1475-2875-8-43.PubMedCentralCrossRefPubMed Nasr A, Iriemenam NC, Giha HA, Balogun HA, Anders RF, Troye-Blomberg M, Elghazali G, Berzins K: FcgammaRIIa (CD32) polymorphism and anti-malarial IgG subclass pattern among Fulani and sympatric ethnic groups living in eastern Sudan. Malar J. 2009, 8: 43-10.1186/1475-2875-8-43.PubMedCentralCrossRefPubMed
11.
go back to reference Cherif MK, Sanou GS, Maiga B, Israelsson E, Ouedraogo AL, Bougouma EC, Diarra A, Ouedraogo A, Ouattara AS, Troye-Blomberg M, Dolo A, Cavanagh DR, Theisen M, Modiano D, Sirima SB, Nebie I: FcgammaRIIa polymorphism and anti-malaria-specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso. Scand J Immunol. 2012, 75: 606-613. 10.1111/j.1365-3083.2012.02690.x.CrossRefPubMed Cherif MK, Sanou GS, Maiga B, Israelsson E, Ouedraogo AL, Bougouma EC, Diarra A, Ouedraogo A, Ouattara AS, Troye-Blomberg M, Dolo A, Cavanagh DR, Theisen M, Modiano D, Sirima SB, Nebie I: FcgammaRIIa polymorphism and anti-malaria-specific IgG and IgG subclass responses in populations differing in susceptibility to malaria in Burkina Faso. Scand J Immunol. 2012, 75: 606-613. 10.1111/j.1365-3083.2012.02690.x.CrossRefPubMed
12.
go back to reference Luoni G, Verra F, Arca B, Sirima BS, Troye-Blomberg M, Coluzzi M, Kwiatkowski D, Modiano D: Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa. Genes Immun. 2001, 2: 411-414. 10.1038/sj.gene.6363797.CrossRefPubMed Luoni G, Verra F, Arca B, Sirima BS, Troye-Blomberg M, Coluzzi M, Kwiatkowski D, Modiano D: Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa. Genes Immun. 2001, 2: 411-414. 10.1038/sj.gene.6363797.CrossRefPubMed
Metadata
Title
Fulani show decreased susceptibility to Plasmodium falciparum infection versus Mossi: data from a community-wide screening and treatment of asymptomatic carriers in Burkina Faso
Authors
Alfred B Tiono
Sodiomon B Sirima
Kamal Hamed
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2013
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-12-163

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