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Open Access 05-09-2023 | Frontotemporal Dementia | Original Article

Application of the mild behavioral impairment checklist in Chinese patients with the behavioral variant of frontotemporal dementia

Authors: Yue Cui, Li Liu, Min Chu, Kexin Xie, Zhongyun Chen, Haitian Nan, Yu Kong, Tianxinyu Xia, Yingtao Wang, Yihao Wang, Qianqian He, Liyong Wu

Published in: Neurological Sciences | Issue 2/2024

Abstract

Background

The mild behavioral impairment checklist (MBI-C) designed to capture neuropsychiatric symptoms in the whole spectrum of elder with or without dementia, have been verified in mild behavioral impairment, mild cognitive impairment and Alzheimer's Disease, but never used in the behavioral variant of frontotemporal dementia (bvFTD).

Methods

Fifty-two patients with bvFTD (mild, n = 30; moderate-severe, n = 22) and 82 community-dwelling elderly individuals (HCs) were enrolled. All subjects were assessed with a full neuropsychological scale including the MBI-C, Neuropsychiatric Inventory Questionnaire (NPI-Q), and Frontal Behavioral Inventory (FBI). Receiver operating characteristic curves were drawn to analyze the sensitivity and specificity of the MBI-C, NPI-Q, and FBI, and cutoff points were determined using the Youden index.

Results

The MBI-C and domain scores in all patients with bvFTD were significantly higher than those in HCs. The most common symptoms of bvFTD were apathy (82.7%) and impulse dyscontrol (80.8%). The MBI-C score was positively correlated with the NPI-Q, FBI, and Activities of Daily Living. For differentiating patients with both bvFTD and mild bvFTD from HCs, the optimal MBI-C cutoff point was 5.5 with a sensitivity of 100% and specificity of 82%, and its sensitivity was higher than that of the NPI-Q and FBI.

Conclusion

The MBI-C is a sensitive tool for screening behavioral and psychological symptoms in patients with bvFTD, even in the early stages of the disease.

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Title: Application of the mild behavioral impairment checklist in Chinese patients with the behavioral variant of frontotemporal dementia
Authors: Yue Cui
Li Liu
Min Chu
Kexin Xie
Zhongyun Chen
Haitian Nan
Yu Kong
Tianxinyu Xia
Yingtao Wang
Yihao Wang
Qianqian He
Liyong Wu
Publication date: 05-09-2023
Publisher: Springer International Publishing
Keywords: Frontotemporal Dementia
Frontotemporal Dementia
Published in: Neurological Sciences / Issue 2/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07049-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Application of the mild behavioral impairment checklist in Chinese patients with the behavioral variant of frontotemporal dementia

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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