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Annals of Hematology
Published in: Annals of Hematology 10/2017

01-10-2017 | Letter to the Editor

Frequency of hemoglobin E/β-thalassemia compound heterozygotes with low hemoglobin F phenotype among cases with a diagnosis of hemoglobin E homozygote, determined by high-performance liquid chromatography, in prenatal control program for β-thalassemia

Authors: Peerapon Wong, Arunee Srichaiya, Pawanrat Suannum, Prissana Charoenporn, Sawichayaporn Jermnim, Monthira Chan-In, Akamon Tapprom, Rawisut Deoisares

Published in: Annals of Hematology | Issue 10/2017

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Excerpt

Dear Editor, …
Literature
1.
Olivieri NF, Pakbaz Z, Vichinsky E (2010) HbE/β-thalassemia: basis of marked clinical diversity. Hematol Oncol Clin North Am 24:1055–1070CrossRefPubMed
2.
Yamsri S, Singha K, Prajantasen T, Taweenan W, Fucharoen G, Sanchaisuriya K, Fucharoen S (2015) A large cohort of β(+)-thalassemia in Thailand: molecular, hematological and diagnostic considerations. Blood Cells Mol Dis 54:164–169CrossRefPubMed
3.
Sae-ung N, Srivorakun H, Fucharoen G, Yamsri S, Sanchaisuriya K, Fucharoen S (2012) Phenotypic expression of hemoglobins A2, E and F in various hemoglobin E related disorders. Blood Cells Mol Dis 48:11–16CrossRefPubMed
4.
Prasing W, Pornprasert S (2014) Measurement of HbA2by capillary electrophoresis for diagnosing β-thalassemia/HbE disease in patients with low HbF. Lab Med 45:226–230CrossRefPubMed
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Saetung R, Ongchai S, Charoenkwan P, Sanguansermsri T (2013) Genotyping of beta thalassemia trait by high-resolution DNA melting analysis. Southeast Asian J Trop Med Public Health 44:1055–1064PubMed
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Sirichotiyakul S, Saetung R, Sanguansermsri T (2003) Analysis of beta-thalassemia mutations in northern Thailand using an automated fluorescence DNA sequencing technique. Hemoglobin 27:89–95CrossRefPubMed
7.
Sanguansermsri T, Phumyu N, Chomchuen S, Steger HF (1999) Screening for alpha-thalassemia-1 heterozygotes in expecting couples by the combination of a simple erythrocyte osmotic fragility test and a PCR-based method. Community Genet 2:26–29PubMed
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Steinberg MH, Adams JG (1991) Hemoglobin A2: origin, evolution, and aftermath. Blood 78:2165–2177PubMed
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Pakdee N, Yamsri S, Fucharoen G, Sanchaisuriya K, Pissard S, Fucharoen S (2014) Variability of hemoglobin F expression in hemoglobin EE disease: hematological and molecular analysis. Blood Cells Mol Dis 53:11–15CrossRefPubMed
Metadata
Title
Frequency of hemoglobin E/β-thalassemia compound heterozygotes with low hemoglobin F phenotype among cases with a diagnosis of hemoglobin E homozygote, determined by high-performance liquid chromatography, in prenatal control program for β-thalassemia
Authors
Peerapon Wong
Arunee Srichaiya
Pawanrat Suannum
Prissana Charoenporn
Sawichayaporn Jermnim
Monthira Chan-In
Akamon Tapprom
Rawisut Deoisares
Publication date
01-10-2017
Publisher
Springer Berlin Heidelberg
Published in
Annals of Hematology / Issue 10/2017
Print ISSN: 0939-5555
Electronic ISSN: 1432-0584
DOI
https://doi.org/10.1007/s00277-017-3089-4

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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