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Allergy, Asthma & Clinical Immunology

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Open Access 01-12-2022 | Food Allergy | Case report

Nasal mucosal reactivity assessment via a double-blind placebo-controlled food challenge with cow’s milk allergens

Authors: Edyta Krzych-Fałta, Oksana Wojas, Piotr Samel-Kowalik, Adam J. Sybilski, Bolesław Samoliński

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2022

Abstract

Background

Allergies, including food allergies, are a considerable clinical and public-health problem. The introduced preventive measures and differential diagnostics, including oral food challenges, are the gold standard for determining further treatment planning.

Case presentation

We present a case of an 18-year-old girl with a cow’s milk allergy who underwent an oral food challenge (double blind oral food challenge). Such a challenge may be confounded by inducing a response from other systems and organs, which provides theoretical grounds for the use of other methods of assessing the body’s response to food allergens (response demonstrated by the upper respiratory tract). Based on this idea, in order to assess the degree of mucosal response, we used optical rhinometry as an objective method for nasal patency evaluation, as well as identification of tryptase level in nasal lavage fluid and exfoliative cytology of nasal mucosa. The results of these tests confirmed positive reaction of the nasal mucosa in the course of the oral allergen challenge.

Conclusions

The observed increase in the nasal mucosal reactivity that accompanies oral food challenges may suggest a potential for using food allergens in nasal allergen provocation testing in order to diagnose food allergies.

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Title: Nasal mucosal reactivity assessment via a double-blind placebo-controlled food challenge with cow’s milk allergens
Authors: Edyta Krzych-Fałta
Oksana Wojas
Piotr Samel-Kowalik
Adam J. Sybilski
Bolesław Samoliński
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Food Allergy
Published in: Allergy, Asthma & Clinical Immunology / Issue 1/2022
Electronic ISSN: 1710-1492
DOI: https://doi.org/10.1186/s13223-022-00700-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Nasal mucosal reactivity assessment via a double-blind placebo-controlled food challenge with cow’s milk allergens

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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