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Archives of Virology
Published in: Archives of Virology 12/2016

01-12-2016 | Brief Report

Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro

Authors: Manik Ghosh, Andrea Civra, Massimo Rittà, Valeria Cagno, Siva Ganesh Mavuduru, Preeti Awasthi, David Lembo, Manuela Donalisio

Published in: Archives of Virology | Issue 12/2016

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Abstract

Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against herpes simplex virus type 2 (HSV-2), the main causative agent of genital ulcers and sores. Water and chloroform bark extracts were the most active against HSV-2, and also against an acyclovir-resistant strain. We demonstrate that the water extract has a direct virus-inactivating activity. By contrast, the chloroform extract inhibits viral attachment and entry and limits the production of viral progeny.
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Metadata
Title
Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro
Authors
Manik Ghosh
Andrea Civra
Massimo Rittà
Valeria Cagno
Siva Ganesh Mavuduru
Preeti Awasthi
David Lembo
Manuela Donalisio
Publication date
01-12-2016
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 12/2016
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3032-3

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