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01-05-2019 | Fibromyalgia | Review

Role of inflammation in the pathogenesis and treatment of fibromyalgia

Author: Ilke Coskun Benlidayi

Published in: Rheumatology International | Issue 5/2019

Abstract

Fibromyalgia is a multifaceted disease. The clinical picture of fibromyalgia covers numerous comorbidities. Each comorbidity stands as a distinct condition. However, common pathophysiologic factors are occupied in their background. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been supposed to have role in the pathogenesis of fibromyalgia. The aim of the present article was to review the current literature regarding the potential role of inflammation in the pathogenesis and treatment of fibromyalgia. A literature search was conducted through PubMed/MEDLINE and Web of Science databases using relevant keywords. Recent evidence on this highly studied topic indicates that fibromyalgia has an immunological background. Cytokines/chemokines, lipid mediators, oxidative stress and several plasma-derived factors underlie the inflammatory state in fibromyalgia. There are potential new therapeutic options targeting inflammatory pathways in fibromyalgia patients. In conclusion, there is evidence to support the inflammation-driven pathways in the pathogenesis of fibromyalgia. However, further research is required to fully understand the network of inflammation and its possible role in diagnosis and/or treatment of fibromyalgia.

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Ribeiro VGC, Mendonça VA, Souza ALC, Fonseca SF, Camargos ACR, Lage VKS, Neves CDC, Santos JM, Teixeira LAC, Vieira ELM, Teixeira Junior AL, Mezêncio B, Fernandes JSC, Leite HR, Poortmans JR, Lacerda ACR (2018) Inflammatory biomarkers responses after acute whole body vibration in fibromyalgia. Braz J Med Biol Res 51:e6775. https://doi.org/10.1590/1414-431X20176775 CrossRefPubMedPubMedCentral

Title: Role of inflammation in the pathogenesis and treatment of fibromyalgia
Author: Ilke Coskun Benlidayi
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Keywords: Fibromyalgia
Fibromyalgia
Cytokines
Published in: Rheumatology International / Issue 5/2019
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-019-04251-6

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Image Credits

STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

At a glance: The STEP trials

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