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Odontology
Published in: Odontology 1/2014

01-01-2014 | Review Article

Fibroblast growth factor signaling in mammalian tooth development

Authors: Chun-Ying Li, Jan Prochazka, Alice F. Goodwin, Ophir D. Klein

Published in: Odontology | Issue 1/2014

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Abstract

In this review, we discuss the central role of fibroblast growth factor (FGF) signaling in mammalian tooth development. The FGF family consists of 22 members, most of which bind to four different receptor tyrosine kinases, which in turn signal through a cascade of intracellular proteins. This signaling regulates a number of cellular processes, including proliferation, differentiation, cell adhesion and cell mobility. FGF signaling first becomes important in the presumptive dental epithelium at the initiation stage of tooth development, and subsequently, it controls the invagination of the dental epithelium into the underlying mesenchyme. Later, FGFs are critical in tooth shape formation and differentiation of ameloblasts and odontoblasts, as well as in the development and homeostasis of the stem cell niche that fuels the continuously growing mouse incisor. In addition, FGF signaling is critical in human teeth, as mutations in genes encoding FGF ligands or receptors result in several congenital syndromes characterized by alterations in tooth number, morphology or enamel structure. The parallel roles of FGF signaling in mouse and human tooth development demonstrate the conserved importance of FGF signaling in mammalian odontogenesis.
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Metadata
Title
Fibroblast growth factor signaling in mammalian tooth development
Authors
Chun-Ying Li
Jan Prochazka
Alice F. Goodwin
Ophir D. Klein
Publication date
01-01-2014
Publisher
Springer Japan
Published in
Odontology / Issue 1/2014
Print ISSN: 1618-1247
Electronic ISSN: 1618-1255
DOI
https://doi.org/10.1007/s10266-013-0142-1

Other articles of this Issue 1/2014

Odontology 1/2014 Go to the issue

Original Article

A two-colored chewing gum test for assessing masticatory performance: a preliminary study

Original Article

Morphometric analysis of the cranial base in Asians

Case Report

Peri-implant bone tissues around retrieved human implants after time periods longer than 5 years: a retrospective histologic and histomorphometric evaluation of 8 cases

Erratum

Erratum to: Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy

Original Article

Fatigue resistance of rotary instruments manufactured using different nickel–titanium alloys: a comparative study

Original Article

Association of gingival recession and other factors with the presence of dentin hypersensitivity