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Journal of Assisted Reproduction and Genetics

27-04-2024 | Fertility | Fertility Preservation

Fertility preservation in males with cancer of trends, region development, and efficacy in mainland China from 16 regions Chinese sperm banks

Authors: Xiao Liu, Qiling Wang, Huiqiang Sheng, Xiaowei Liang, Zhiqiang Wang, Tianqing Meng, Yushan Li, Hao Dong, Wenbing Zhu, Jigao Yang, Zhou Zhang, Xianglong Jiang, Aiping Zhang, Zuowen Liang, Xiaojin He, Chunying Song, Fuping Li, Xinzong Zhang

Published in: Journal of Assisted Reproduction and Genetics

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Abstract

Purpose

Male cancer survivors experience confusion about fertility following cancer treatment. The aims of this study were to evaluate survivors’ semen quality in different tumor type groups in China and to analyze the current situation and challenges of male cancer patients with sperm cryopreservation.

Methods

This was a multicenter retrospective study of male patients with cancer who underwent sperm cryopreservation in 16 regions of the national sperm banks over an 11-year period from 2010 to 2020.

Results

The number of male cancer patients with sperm cryopreservation showed an overall upward trend. The development of male cancer fertility preservation (FP) in the eastern, central, and western regions of Chinese displayed imbalance. There are seven tumor types for sperm preservation in the top incidence ten tumor types, including lymphoma, leukemia, nasopharyngeal carcinoma, sarcoma, thyroid cancer, and brain tumor. Moreover, nasopharyngeal carcinoma is a high incidence rate in China, which is related to high sperm preservation rate, different from other countries. The most percentage of males receiving sperm cryopreservation in the testicular cancers (15–39 years old) of China in 2020 was 5.55%, 1.29% in the lymphoma, and 0.39% in the leukemia. According to the type of cancer, a statistically significant lower pre-sperm density, total sperm output, and post-sperm density was observed in testicular cancers. It is worth noting that the prevalence of azoospermia 22.2% in leukemia patients attribute to urgent treatment before sperm cryopreservation. Disposition of cryopreserved sperm categories included continued storage (47.2%), discarded (9%), death (0.9%), and use (3.7%).

Conclusion

This study provides the first comprehensive national statistical census and review of fertility preservation in male cancer patients with respect to trends, prevalence, and cancer types. The development of male cancer fertility preservation in China is imbalanced and percentage of males receiving sperm cryopreservation in the adolescent and young adult cancers was low. Sixteen human sperm banks from China analyze current problems and challenges, and then prioritize steps toward the achievement of the FP strategy framework for Healthy China 2030.
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Metadata
Title
Fertility preservation in males with cancer of trends, region development, and efficacy in mainland China from 16 regions Chinese sperm banks
Authors
Xiao Liu
Qiling Wang
Huiqiang Sheng
Xiaowei Liang
Zhiqiang Wang
Tianqing Meng
Yushan Li
Hao Dong
Wenbing Zhu
Jigao Yang
Zhou Zhang
Xianglong Jiang
Aiping Zhang
Zuowen Liang
Xiaojin He
Chunying Song
Fuping Li
Xinzong Zhang
Publication date
27-04-2024
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-024-03121-w