Skip to main content
Top
Published in: Journal of Nephrology 1/2019

01-02-2019 | Fertility | Review

Fertility and reproductive care in chronic kidney disease

Authors: Sandra Marie Dumanski, Sofia Bano Ahmed

Published in: Journal of Nephrology | Issue 1/2019

Login to get access

Abstract

In both women and men, chronic kidney disease (CKD) is associated with decreased fertility. Though a multitude of factors contribute to the reduction in fertility in this population, progressively impaired function of the hypothalamic–pituitary–gonadal axis appears to play a key role in the pathophysiology. There is limited research on strategies to manage infertility in the CKD population, but intensive hemodialysis, kidney transplantation, medication management and assisted reproductive technologies (ART) have all been proposed. Though fertility and reproductive care are reported as important elements of care by CKD patients themselves, few nephrology clinicians routinely address fertility and reproductive care in clinical interactions. Globally, the average age of parenthood is increasing, with concurrent growth and expansion in the use of ART. Coupled with an increasing prevalence of CKD in women and men of reproductive age, the importance of understanding fertility and reproductive technologies in this population is highlighted. This review endeavors to explore the female and male factors that affect fertility in the CKD population, as well as the evidence supporting strategies for reproductive care.
Literature
1.
go back to reference Wiles KS, Nelson-Piercy C, Bramham K (2018) Reproductive health and pregnancy in women with chronic kidney disease. Nat Rev Nephrol 14:165–184CrossRefPubMed Wiles KS, Nelson-Piercy C, Bramham K (2018) Reproductive health and pregnancy in women with chronic kidney disease. Nat Rev Nephrol 14:165–184CrossRefPubMed
3.
go back to reference Piccoli GB, Conijn A, Consiglio V, Vasario E, Attini R, Deagostini MC et al (2010) Pregnancy in dialysis patients: is the evidence strong enough to lead us to change our counselling policy? Clin J Am Soc Nephrol 5:62–71CrossRefPubMedPubMedCentral Piccoli GB, Conijn A, Consiglio V, Vasario E, Attini R, Deagostini MC et al (2010) Pregnancy in dialysis patients: is the evidence strong enough to lead us to change our counselling policy? Clin J Am Soc Nephrol 5:62–71CrossRefPubMedPubMedCentral
4.
go back to reference Lehtihet M, Hylander B (2015) Semen quality in men with chronic kidney disease and its correlation with chronic kidney disease stages. Andrologia 47:1103–1108CrossRefPubMed Lehtihet M, Hylander B (2015) Semen quality in men with chronic kidney disease and its correlation with chronic kidney disease stages. Andrologia 47:1103–1108CrossRefPubMed
5.
go back to reference Holley JL, Schmidt RJ (2013) Changes in fertility and hormone replacement therapy in kidney disease. Adv Chronic Kidney Dis 20(3):240–245CrossRefPubMed Holley JL, Schmidt RJ (2013) Changes in fertility and hormone replacement therapy in kidney disease. Adv Chronic Kidney Dis 20(3):240–245CrossRefPubMed
6.
go back to reference Van Ek GF, Krouwel EM, Nicolai MPJ, Den Oudsten BL, Den Ouden MEM, Dieben SWM et al (2017) What is the role of nephrologists and nurses of the dialysis department in providing fertility care to CKD patients? A questionnaire study among care providers. Int Urol Nephrol 49:1273–1285CrossRefPubMedPubMedCentral Van Ek GF, Krouwel EM, Nicolai MPJ, Den Oudsten BL, Den Ouden MEM, Dieben SWM et al (2017) What is the role of nephrologists and nurses of the dialysis department in providing fertility care to CKD patients? A questionnaire study among care providers. Int Urol Nephrol 49:1273–1285CrossRefPubMedPubMedCentral
7.
go back to reference Ramesh S, James MT, Holroyd-Leduc JM, Wilton SB, Seely EW, Wheeler DC, Ahmed SB (2017) Sex hormone status in women with chronic kidney disease: survey of nephrologists’ and renal allied health care providers’ perceptions. Can J Kidney Health Dis 4:1–13CrossRef Ramesh S, James MT, Holroyd-Leduc JM, Wilton SB, Seely EW, Wheeler DC, Ahmed SB (2017) Sex hormone status in women with chronic kidney disease: survey of nephrologists’ and renal allied health care providers’ perceptions. Can J Kidney Health Dis 4:1–13CrossRef
8.
go back to reference Tong A, Jesudason S, Craig JC, Winkelmayer WC (2015) Perspectives on pregnancy in women with chronic kidney disease: systematic review of qualitative studies. Nephrol Dial Transplant 30:652–661CrossRefPubMed Tong A, Jesudason S, Craig JC, Winkelmayer WC (2015) Perspectives on pregnancy in women with chronic kidney disease: systematic review of qualitative studies. Nephrol Dial Transplant 30:652–661CrossRefPubMed
9.
go back to reference Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callaghan CA, Lasserson DS, Hobbs FDR (2016) Global prevalence of chronic kidney disease—a systematic review and meta-analysis. PLoS One 11(7):e0158765CrossRefPubMedPubMedCentral Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callaghan CA, Lasserson DS, Hobbs FDR (2016) Global prevalence of chronic kidney disease—a systematic review and meta-analysis. PLoS One 11(7):e0158765CrossRefPubMedPubMedCentral
10.
go back to reference Vinhas J, Gardete-Correia L, Boavida JM, Raposo JF, Mesquita A, Fona MC et al (2011) Prevalence of chronic kidney disease and associated risk factors, and risk of end-stage renal disease: data from the PREVADIAB study. Nephron Clin Pract 119:c35–40CrossRefPubMed Vinhas J, Gardete-Correia L, Boavida JM, Raposo JF, Mesquita A, Fona MC et al (2011) Prevalence of chronic kidney disease and associated risk factors, and risk of end-stage renal disease: data from the PREVADIAB study. Nephron Clin Pract 119:c35–40CrossRefPubMed
11.
go back to reference Jiang L, Liang Y, Qiu B, Wang F, Duan X, Yang X et al (2010) Prevalence of chronic kidney disease in a rural Chinese adult population: the Handan Eye Study. Nephron 114(4):C295–C302PubMed Jiang L, Liang Y, Qiu B, Wang F, Duan X, Yang X et al (2010) Prevalence of chronic kidney disease in a rural Chinese adult population: the Handan Eye Study. Nephron 114(4):C295–C302PubMed
12.
go back to reference Kramer H, Palmas W, Kestenbaum B, Cushman M, Allison M, Astor B et al (2008) Chronic kidney disease prevalence estimates among racial/ethnic groups: the multi-ethnic study of atherosclerosis. Clin J Am Soc Nephrol 3(5):1391–1397CrossRefPubMedPubMedCentral Kramer H, Palmas W, Kestenbaum B, Cushman M, Allison M, Astor B et al (2008) Chronic kidney disease prevalence estimates among racial/ethnic groups: the multi-ethnic study of atherosclerosis. Clin J Am Soc Nephrol 3(5):1391–1397CrossRefPubMedPubMedCentral
13.
go back to reference White SL, Polkinghorne KR, Atkins RC, Chadban SJ (2010) Comparison of the prevalence and mortality risk of CKD in Australia using the CKD epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study GFR estimating equations: the AusDiab (Australian Diabetes, Obesity and Lifestyle) Study. Am J Kidney Dis 55(4):660–670CrossRefPubMed White SL, Polkinghorne KR, Atkins RC, Chadban SJ (2010) Comparison of the prevalence and mortality risk of CKD in Australia using the CKD epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study GFR estimating equations: the AusDiab (Australian Diabetes, Obesity and Lifestyle) Study. Am J Kidney Dis 55(4):660–670CrossRefPubMed
14.
go back to reference Juutilainen A, Kastarinen H, Antikainen R, Peltonen M, Salomaa V, Tuomilehto J et al (2012) Trends in estimated kidney function: the FINRISK surveys. Eur J Epidemiol 27(4):305–313CrossRefPubMed Juutilainen A, Kastarinen H, Antikainen R, Peltonen M, Salomaa V, Tuomilehto J et al (2012) Trends in estimated kidney function: the FINRISK surveys. Eur J Epidemiol 27(4):305–313CrossRefPubMed
15.
16.
go back to reference Barclay K, Myrskyla M (2016) Advanced maternal age and offspring outcomes: reproductive aging and counterbalancing period trends. Popul Dev Rev 42(1):61–94CrossRef Barclay K, Myrskyla M (2016) Advanced maternal age and offspring outcomes: reproductive aging and counterbalancing period trends. Popul Dev Rev 42(1):61–94CrossRef
17.
go back to reference Piccoli GB, Minelli F, Versino E, Cabiddu G, Attini R, Vigotti FN et al (2016) Pregnancy in dialysis patients in the new millennium: a systematic review and meta-regression analysis correlating dialysis schedules and pregnancy outcomes. Nephrol Dial Transplant 31(11):1915–1934CrossRefPubMed Piccoli GB, Minelli F, Versino E, Cabiddu G, Attini R, Vigotti FN et al (2016) Pregnancy in dialysis patients in the new millennium: a systematic review and meta-regression analysis correlating dialysis schedules and pregnancy outcomes. Nephrol Dial Transplant 31(11):1915–1934CrossRefPubMed
18.
go back to reference Nazario RDCP, Turato ER (2007) Fantasies about pregnancy and motherhood reported by fertile adult women under hemodialysis in the Brazilian Southeast: a clinical-qualitative study. Rev Lat Am Enferm 15:55–61CrossRef Nazario RDCP, Turato ER (2007) Fantasies about pregnancy and motherhood reported by fertile adult women under hemodialysis in the Brazilian Southeast: a clinical-qualitative study. Rev Lat Am Enferm 15:55–61CrossRef
19.
go back to reference Eckardt K, Coresh J, Devuyst O, Johnson RJ, Kottgen A, Levey AS et al (2013) Evolving importance of kidney disease: From subspecialty to global health burden. Lancet 382(9887):158–69CrossRefPubMed Eckardt K, Coresh J, Devuyst O, Johnson RJ, Kottgen A, Levey AS et al (2013) Evolving importance of kidney disease: From subspecialty to global health burden. Lancet 382(9887):158–69CrossRefPubMed
22.
go back to reference Cochrane R, Regan L (1997) Undetected gynaecological disorders in women with renal disease. Hum Reprod 12(4):667–670CrossRefPubMed Cochrane R, Regan L (1997) Undetected gynaecological disorders in women with renal disease. Hum Reprod 12(4):667–670CrossRefPubMed
23.
go back to reference Ahmed SB, Ramesh S (2016) Sex hormones in women with kidney disease. Nephrol Dial Transplant 31(11):1787–1795CrossRefPubMed Ahmed SB, Ramesh S (2016) Sex hormones in women with kidney disease. Nephrol Dial Transplant 31(11):1787–1795CrossRefPubMed
24.
go back to reference Piccoli GB, Cabiddu G, Attini R, Vigotti F, Fassio F, Rolfo A et al (2015) Pregnancy in chronic kidney disease: questions and answers in a changing panorama. Best Pract Res Clin Obstet Gynaecol 29:625–642CrossRefPubMed Piccoli GB, Cabiddu G, Attini R, Vigotti F, Fassio F, Rolfo A et al (2015) Pregnancy in chronic kidney disease: questions and answers in a changing panorama. Best Pract Res Clin Obstet Gynaecol 29:625–642CrossRefPubMed
25.
go back to reference Piccoli GB, Cabiddu G, Daidone G, Guzzo G, Maxia S, Ciniglio I et al (2014) The children of dialysis: Live-born babies from on-dialysis mothers in Italy—an epideminological perspective comparing dialysis, kidney transplantation and the overall population. Nephrol Dial Transplant 29(8):1578–1586CrossRefPubMed Piccoli GB, Cabiddu G, Daidone G, Guzzo G, Maxia S, Ciniglio I et al (2014) The children of dialysis: Live-born babies from on-dialysis mothers in Italy—an epideminological perspective comparing dialysis, kidney transplantation and the overall population. Nephrol Dial Transplant 29(8):1578–1586CrossRefPubMed
26.
go back to reference Knight M, Kurinczuk JJ, Tuffnell D, Brocklehurst P (2005) The UK obstetric surveillance system for rare disorders of pregnancy. BJOG 112:263–265CrossRefPubMed Knight M, Kurinczuk JJ, Tuffnell D, Brocklehurst P (2005) The UK obstetric surveillance system for rare disorders of pregnancy. BJOG 112:263–265CrossRefPubMed
28.
go back to reference Bramham K, Nelson-Piercy C, Gao H, Pierce M, Bush N, Spark P et al (2013) Pregnancy in renal transplant recipients: a UK national cohort study. Clin J Am Soc Nephrol 8:290–298CrossRefPubMed Bramham K, Nelson-Piercy C, Gao H, Pierce M, Bush N, Spark P et al (2013) Pregnancy in renal transplant recipients: a UK national cohort study. Clin J Am Soc Nephrol 8:290–298CrossRefPubMed
29.
go back to reference Holley JL, Schmidt RJ, Bender FH (1997) Gynecologic and reproductive issues in women on dialysis. Am J Kidney Dis 29(5):685–690CrossRefPubMed Holley JL, Schmidt RJ, Bender FH (1997) Gynecologic and reproductive issues in women on dialysis. Am J Kidney Dis 29(5):685–690CrossRefPubMed
30.
go back to reference Lim VS, Henriquez C, Sievertsen G, Frohman LA (1980) Ovarian function in chronic renal failure: evidence suggesting hypothalamic anovulation. Ann Int Med 93(1):21–27CrossRefPubMed Lim VS, Henriquez C, Sievertsen G, Frohman LA (1980) Ovarian function in chronic renal failure: evidence suggesting hypothalamic anovulation. Ann Int Med 93(1):21–27CrossRefPubMed
32.
go back to reference Ahmed SB, Vitek WS, Holley JL (2017) Fertility, contraception, and novel reproductive technologies in chronic kidney disease. Semin Nephrol 37(4):327–336CrossRefPubMed Ahmed SB, Vitek WS, Holley JL (2017) Fertility, contraception, and novel reproductive technologies in chronic kidney disease. Semin Nephrol 37(4):327–336CrossRefPubMed
33.
go back to reference Sievertsen GD, Lim VS, Nakawatase C, Frohman LA (1980) Metabolic clearance and secretion rates of human prolactin in normal subjects and in patients with chronic renal failure. J Clin Endocrinol Metab 5(1):846–852CrossRef Sievertsen GD, Lim VS, Nakawatase C, Frohman LA (1980) Metabolic clearance and secretion rates of human prolactin in normal subjects and in patients with chronic renal failure. J Clin Endocrinol Metab 5(1):846–852CrossRef
34.
go back to reference Matuszkiewicz-Rowinska J, Skorzewska K, Radowicki S, Niemczyk S, Sokalski A, Przedlacki J et al (2004) Endometrial morphology and pituitary–gonadal axis dysfunction in women of reproductive age undergoing chronic haemodialysis—a multicenter study. Nephrol Dial Transplant 19:2074–2077CrossRefPubMed Matuszkiewicz-Rowinska J, Skorzewska K, Radowicki S, Niemczyk S, Sokalski A, Przedlacki J et al (2004) Endometrial morphology and pituitary–gonadal axis dysfunction in women of reproductive age undergoing chronic haemodialysis—a multicenter study. Nephrol Dial Transplant 19:2074–2077CrossRefPubMed
35.
go back to reference Chakhtoura Z, Meunier M, Caby J, Mercadal L, Arzouk N, Barrou B, Touraine P (2015) Gynecologic followup of 129 women on dialysis and after kidney transplantation: a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol 187:1–5CrossRefPubMed Chakhtoura Z, Meunier M, Caby J, Mercadal L, Arzouk N, Barrou B, Touraine P (2015) Gynecologic followup of 129 women on dialysis and after kidney transplantation: a retrospective cohort study. Eur J Obstet Gynecol Reprod Biol 187:1–5CrossRefPubMed
36.
go back to reference Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW et al (2012) Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause 19(4):387–395CrossRefPubMedPubMedCentral Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW et al (2012) Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause 19(4):387–395CrossRefPubMedPubMedCentral
37.
go back to reference Rose C, Gill J, Zalunardo N, Johnston O, Mehrotra A, Gill JS (2016) Timing of pregnancy after kidney transplantation and risk of allograft failure. Am J Transplant 16:2360–2367CrossRefPubMed Rose C, Gill J, Zalunardo N, Johnston O, Mehrotra A, Gill JS (2016) Timing of pregnancy after kidney transplantation and risk of allograft failure. Am J Transplant 16:2360–2367CrossRefPubMed
38.
go back to reference Filocamo JT, Zanazzi M, Marzi VL, Lombardi G, Popolo GD, Mancini G et al (2009) Sexual dysfunction in women during dialysis and after renal transplantation. J Sex Med 6:3125–3131CrossRefPubMed Filocamo JT, Zanazzi M, Marzi VL, Lombardi G, Popolo GD, Mancini G et al (2009) Sexual dysfunction in women during dialysis and after renal transplantation. J Sex Med 6:3125–3131CrossRefPubMed
39.
go back to reference Tauchmanova L, Carraro R, Sabbatini M, De Rosa M, Orio F, Palomba S et al (2004) Hypothalamic–pituitary–gonadal axis function after successful kidney transplantation in men and women. Hum Reprod 19:867–873CrossRefPubMed Tauchmanova L, Carraro R, Sabbatini M, De Rosa M, Orio F, Palomba S et al (2004) Hypothalamic–pituitary–gonadal axis function after successful kidney transplantation in men and women. Hum Reprod 19:867–873CrossRefPubMed
40.
go back to reference Pietrzak B, Wielgos M, Kaminski P, Jabiry-Zieniewicz Z, Bobrowska K (2006) Menstrual cycle and sex hormone profile in kidney-transplanted women. Neuro Endocrinol Lett 27:198–202PubMed Pietrzak B, Wielgos M, Kaminski P, Jabiry-Zieniewicz Z, Bobrowska K (2006) Menstrual cycle and sex hormone profile in kidney-transplanted women. Neuro Endocrinol Lett 27:198–202PubMed
41.
go back to reference Barua M, Hladunewich M, Keunen J, Pierratos A, McFarlane P, Sood M, Chan CT (2008) Successful pregnancies on nocturnal home hemodialysis. Clin J Am Soc Nephrol 3:392–396CrossRefPubMedPubMedCentral Barua M, Hladunewich M, Keunen J, Pierratos A, McFarlane P, Sood M, Chan CT (2008) Successful pregnancies on nocturnal home hemodialysis. Clin J Am Soc Nephrol 3:392–396CrossRefPubMedPubMedCentral
42.
go back to reference Van Eps C, Hawley C, Jeffries J, Johnson DW, Campbell S, Isbel N et al (2012) Changes in serum prolactin, sex hormones and thyroid function with alternate nightly nocturnal home haemodialysis. Nephrology 17:42–47CrossRefPubMed Van Eps C, Hawley C, Jeffries J, Johnson DW, Campbell S, Isbel N et al (2012) Changes in serum prolactin, sex hormones and thyroid function with alternate nightly nocturnal home haemodialysis. Nephrology 17:42–47CrossRefPubMed
43.
go back to reference Wilkosz P, Greggains GD, Tanbo TG, Fedorcsak P (2014) Female reproductive decline is determined by remaining ovarian reserve and age. PLoS One 9(10):e108343CrossRefPubMedPubMedCentral Wilkosz P, Greggains GD, Tanbo TG, Fedorcsak P (2014) Female reproductive decline is determined by remaining ovarian reserve and age. PLoS One 9(10):e108343CrossRefPubMedPubMedCentral
44.
go back to reference Iwase A, Nakamura T, Osuka S, Takikawa S, Goto M, Kikkawa F (2015) Anti-Mullerian hormone as a marker of ovarian reserve: what we have learned and what should we know? Reprod Med Biol 15(3):127–136CrossRefPubMedPubMedCentral Iwase A, Nakamura T, Osuka S, Takikawa S, Goto M, Kikkawa F (2015) Anti-Mullerian hormone as a marker of ovarian reserve: what we have learned and what should we know? Reprod Med Biol 15(3):127–136CrossRefPubMedPubMedCentral
45.
go back to reference Stoumpos S, Lees J, Welsh P, Hund M, Geddes CC, Nelson SM, Mark PB (2018) The utility of anti-Mullerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reprod Biomed Online 36:219–226CrossRefPubMed Stoumpos S, Lees J, Welsh P, Hund M, Geddes CC, Nelson SM, Mark PB (2018) The utility of anti-Mullerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reprod Biomed Online 36:219–226CrossRefPubMed
46.
go back to reference Sikora-Grabka E, Adamczak M, Kuczera P, Szotowska M, Madej P, Wiecek A (2016) Serum anti-Mullerian hormone concentration in young women with chronic kidney disease on hemodialysis, and after successful kidney transplantation. Kidney Blood Press Res 41:552–560CrossRefPubMed Sikora-Grabka E, Adamczak M, Kuczera P, Szotowska M, Madej P, Wiecek A (2016) Serum anti-Mullerian hormone concentration in young women with chronic kidney disease on hemodialysis, and after successful kidney transplantation. Kidney Blood Press Res 41:552–560CrossRefPubMed
47.
go back to reference Cui L, Sheng Y, Sun M, Hu J, Qin Y, Chen Z (2016) Chronic pelvic inflammation diminished ovarian reserve as indicated by serum anti-Mullerian hormone. PLoS One 11(6):e0156130CrossRefPubMedPubMedCentral Cui L, Sheng Y, Sun M, Hu J, Qin Y, Chen Z (2016) Chronic pelvic inflammation diminished ovarian reserve as indicated by serum anti-Mullerian hormone. PLoS One 11(6):e0156130CrossRefPubMedPubMedCentral
48.
go back to reference Senates E, Colak Y, Erdem ED, Yesil A, Coskunpinar E, Sahin O et al (2013) Serum anti-Mullerian hormone levels are lower in reproductive age women with Crohn’s disease compared to healthy control women. Crohn’s Colitis 7:e29–e34CrossRef Senates E, Colak Y, Erdem ED, Yesil A, Coskunpinar E, Sahin O et al (2013) Serum anti-Mullerian hormone levels are lower in reproductive age women with Crohn’s disease compared to healthy control women. Crohn’s Colitis 7:e29–e34CrossRef
49.
go back to reference Chen L, Yang T, Lu D, Feng Y, Chen H, Chen D et al (2018) Central role of dysregulation of TGF-B/Smad in CKD progression and potential targets of its treatment. Biomed Pharmacother 101:670–681CrossRefPubMed Chen L, Yang T, Lu D, Feng Y, Chen H, Chen D et al (2018) Central role of dysregulation of TGF-B/Smad in CKD progression and potential targets of its treatment. Biomed Pharmacother 101:670–681CrossRefPubMed
50.
go back to reference Dumont A, Robin G, Catteau-Jonard S, Dewailly D (2015) Role of anti-Mullerian hormone in pathophysiology, diagnosis and treatment of polycystic ovary syndrome: a review. Reprod Biol Endocrinol 13:137CrossRefPubMedPubMedCentral Dumont A, Robin G, Catteau-Jonard S, Dewailly D (2015) Role of anti-Mullerian hormone in pathophysiology, diagnosis and treatment of polycystic ovary syndrome: a review. Reprod Biol Endocrinol 13:137CrossRefPubMedPubMedCentral
51.
go back to reference Garg D, Tal R (2016) The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reprod Biomed Online 33:15–28CrossRefPubMed Garg D, Tal R (2016) The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reprod Biomed Online 33:15–28CrossRefPubMed
52.
go back to reference Basok EK, Atsu N, Rifaioglu MM, Kantarci G, Yildirim A, Tokuc R (2009) Assessment of female sexual function and quality of life in predialysis, peritoneal dialysis, hemodialysis, and renal transplant patients. Int Urol Nephrol 41:473–481CrossRefPubMed Basok EK, Atsu N, Rifaioglu MM, Kantarci G, Yildirim A, Tokuc R (2009) Assessment of female sexual function and quality of life in predialysis, peritoneal dialysis, hemodialysis, and renal transplant patients. Int Urol Nephrol 41:473–481CrossRefPubMed
54.
go back to reference Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F et al (2010) Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis 56(4):670–685CrossRefPubMed Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F et al (2010) Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis 56(4):670–685CrossRefPubMed
55.
go back to reference Okundaye I, Abrinko P, Hou S (1998) Registry of pregnancy in dialysis patients. Am J Kidney Dis 31(5):766–773CrossRefPubMed Okundaye I, Abrinko P, Hou S (1998) Registry of pregnancy in dialysis patients. Am J Kidney Dis 31(5):766–773CrossRefPubMed
56.
go back to reference Shahir AK, Briggs N, Katsoulis J, Levidiotis V (2013) An observational outcomes study from 1966 to 2008, examining pregnancy and neonatal outcomes from dialysed women using data from the ANZDATA registry. Nephrology 18:276–284CrossRefPubMed Shahir AK, Briggs N, Katsoulis J, Levidiotis V (2013) An observational outcomes study from 1966 to 2008, examining pregnancy and neonatal outcomes from dialysed women using data from the ANZDATA registry. Nephrology 18:276–284CrossRefPubMed
57.
58.
59.
go back to reference Houssiau F, Vasconcelos C, D’Cruz D, Sebastiani G, Garrido E, Danieli M et al (2002) Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 46:2121–2131CrossRefPubMed Houssiau F, Vasconcelos C, D’Cruz D, Sebastiani G, Garrido E, Danieli M et al (2002) Immunosuppressive therapy in lupus nephritis: the Euro-Lupus Nephritis Trial, a randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 46:2121–2131CrossRefPubMed
60.
go back to reference Zhang X, Li C, Ma X, Zhao J, An Y, Liu S et al (2014) Short-interval lower-dose intravenous cyclophosphamide as induction and maintenance therapy for lupus nephritis: a prospective observational study. Clin Rheumatol 33:939–945CrossRefPubMed Zhang X, Li C, Ma X, Zhao J, An Y, Liu S et al (2014) Short-interval lower-dose intravenous cyclophosphamide as induction and maintenance therapy for lupus nephritis: a prospective observational study. Clin Rheumatol 33:939–945CrossRefPubMed
63.
go back to reference Elizur S, Chian R, Pineau C, Son W, Holzer H, Huang J et al (2008) Fertility preservation treatment for young women with autoimmune diseases facing treatment with gonadotoxic agents. Rheumatology 47(10):1506–1509CrossRefPubMed Elizur S, Chian R, Pineau C, Son W, Holzer H, Huang J et al (2008) Fertility preservation treatment for young women with autoimmune diseases facing treatment with gonadotoxic agents. Rheumatology 47(10):1506–1509CrossRefPubMed
64.
go back to reference Rodriguez-Wallberg KA, Oktay K (2012) Recent advances in oocyte and ovarian tissue cryopreservation and transplantation. Best Pract Res Clin Obstet Gynaecol 26(3):391–405CrossRefPubMedPubMedCentral Rodriguez-Wallberg KA, Oktay K (2012) Recent advances in oocyte and ovarian tissue cryopreservation and transplantation. Best Pract Res Clin Obstet Gynaecol 26(3):391–405CrossRefPubMedPubMedCentral
65.
go back to reference Lambertini M, Boni L, Michelotti A, Gamucci T, Scotto T, Gori S et al (2015) Ovarian suppression with triptorelin during adjuvant breast cancer chemotherapy and long-term ovarian function, pregnancies, and disease-free survival. JAMA 314(24):2632–2640CrossRefPubMed Lambertini M, Boni L, Michelotti A, Gamucci T, Scotto T, Gori S et al (2015) Ovarian suppression with triptorelin during adjuvant breast cancer chemotherapy and long-term ovarian function, pregnancies, and disease-free survival. JAMA 314(24):2632–2640CrossRefPubMed
66.
go back to reference Somers EC, Marder W, Christman GM, Ognenovski V, McCune WJ (2005) Use of a gonadotropin-releaseing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus. Arthritis Rheum 52:2761–2767CrossRefPubMed Somers EC, Marder W, Christman GM, Ognenovski V, McCune WJ (2005) Use of a gonadotropin-releaseing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus. Arthritis Rheum 52:2761–2767CrossRefPubMed
67.
go back to reference Marder W, McCune WJ, Wang L, Wing JJ, Fisseha S, McConnell DS et al (2012) Adjunctive GnRH-a treatment attenuates depletion of ovarian reserve associated with cyclophosphamide therapy in premenopausal SLE patients. Gynecol Endocrinol 28:624–627CrossRefPubMedPubMedCentral Marder W, McCune WJ, Wang L, Wing JJ, Fisseha S, McConnell DS et al (2012) Adjunctive GnRH-a treatment attenuates depletion of ovarian reserve associated with cyclophosphamide therapy in premenopausal SLE patients. Gynecol Endocrinol 28:624–627CrossRefPubMedPubMedCentral
68.
go back to reference Sullivan-Pyke CS, Senapati S, Mainigi MA, Barnhart KT (2017) In vitro fertilization and adverse obstetric and perinatal outcomes. Semin Perinatol 41(6):345–353CrossRefPubMedPubMedCentral Sullivan-Pyke CS, Senapati S, Mainigi MA, Barnhart KT (2017) In vitro fertilization and adverse obstetric and perinatal outcomes. Semin Perinatol 41(6):345–353CrossRefPubMedPubMedCentral
69.
go back to reference Orquevaux P, Masseau A, Le Guern V, Gayet V, Vauthier D, Guettrot-Imbert G et al (2017) In vitro fertilization in 37 women with systemic lupus erythematosus or antiphospholipid syndrome: a series of 97 procedures. J Rheumatol 44:613–618CrossRefPubMed Orquevaux P, Masseau A, Le Guern V, Gayet V, Vauthier D, Guettrot-Imbert G et al (2017) In vitro fertilization in 37 women with systemic lupus erythematosus or antiphospholipid syndrome: a series of 97 procedures. J Rheumatol 44:613–618CrossRefPubMed
70.
go back to reference Pietrzak B, Mazanowska N, Kocixzewska-Najman B, Szymusik I, Grzechocinska B, Pazik J et al (2015) Successful pregnancy outcome after in vitro fertilization in a kidney graft recipient: a case report and literature review. Ann Transplant 20:338–341CrossRefPubMed Pietrzak B, Mazanowska N, Kocixzewska-Najman B, Szymusik I, Grzechocinska B, Pazik J et al (2015) Successful pregnancy outcome after in vitro fertilization in a kidney graft recipient: a case report and literature review. Ann Transplant 20:338–341CrossRefPubMed
71.
go back to reference Nouri K, Bader Y, Helmy S, Ott J, Jirecek S, Tempfer CB (2011) Live birth after in vitro fertilization and single embryo transfer in a kidney transplant patient: a case report and review of the literature. J Assist Reprod Genet 28(4):351–353CrossRefPubMed Nouri K, Bader Y, Helmy S, Ott J, Jirecek S, Tempfer CB (2011) Live birth after in vitro fertilization and single embryo transfer in a kidney transplant patient: a case report and review of the literature. J Assist Reprod Genet 28(4):351–353CrossRefPubMed
72.
go back to reference Norrman E, Bergh C, Wennerholm U (2015) Pregnancy outcome and long-term follow-up after in vitro fertilization in women with renal transplantation. Human Reprod 30(1):205–213CrossRef Norrman E, Bergh C, Wennerholm U (2015) Pregnancy outcome and long-term follow-up after in vitro fertilization in women with renal transplantation. Human Reprod 30(1):205–213CrossRef
73.
go back to reference Marak CP, Chopra A, Alappan N, Ponea AM, Guddati AK (2013) Ovarian hyperstimulation syndrome as an etiology of obstructive uropathy. Case Rep Obstet Gynecol 2013:653704PubMedPubMedCentral Marak CP, Chopra A, Alappan N, Ponea AM, Guddati AK (2013) Ovarian hyperstimulation syndrome as an etiology of obstructive uropathy. Case Rep Obstet Gynecol 2013:653704PubMedPubMedCentral
74.
go back to reference Thoreau A, Tran PL, Gabriele M, Marie HFS, Boukerrou M (2018) Ureteral obstruction and ruptured kidney following ovarian hyperstimulation syndrome. J Gynecol Obstet Hum Reprod 47(4):167–169CrossRefPubMed Thoreau A, Tran PL, Gabriele M, Marie HFS, Boukerrou M (2018) Ureteral obstruction and ruptured kidney following ovarian hyperstimulation syndrome. J Gynecol Obstet Hum Reprod 47(4):167–169CrossRefPubMed
75.
go back to reference Al-Inany HG, Youssef MA, Ayeleke RO, Brown J, Lam WS, Broekmans FJ (2016) Gonadotropin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev 4:CD001750PubMed Al-Inany HG, Youssef MA, Ayeleke RO, Brown J, Lam WS, Broekmans FJ (2016) Gonadotropin-releasing hormone antagonists for assisted reproductive technology. Cochrane Database Syst Rev 4:CD001750PubMed
76.
go back to reference Piccoli B, Arduino S, Attini R, Parisi S, Fassio F, Biolcati M et al (2013) Multiple pregnancies in CKD patients: an explosive mix. Clin J Am Soc Nephrol 8(1):41–50CrossRefPubMed Piccoli B, Arduino S, Attini R, Parisi S, Fassio F, Biolcati M et al (2013) Multiple pregnancies in CKD patients: an explosive mix. Clin J Am Soc Nephrol 8(1):41–50CrossRefPubMed
77.
go back to reference Iglesias P, Carrero JJ, Diez JJ (2012) Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options. J Nephrol 25(1):31–42CrossRefPubMed Iglesias P, Carrero JJ, Diez JJ (2012) Gonadal dysfunction in men with chronic kidney disease: clinical features, prognostic implications and therapeutic options. J Nephrol 25(1):31–42CrossRefPubMed
78.
go back to reference Zachoval R, Jarabak J, Slatinska J, Burgelova M, Sobotka V, Vranova J, Krhut J (2013) Dynamics of fertility in patients on waiting list for kidney transplantation. Bratisl Lek Listy 114(12):711–715PubMed Zachoval R, Jarabak J, Slatinska J, Burgelova M, Sobotka V, Vranova J, Krhut J (2013) Dynamics of fertility in patients on waiting list for kidney transplantation. Bratisl Lek Listy 114(12):711–715PubMed
79.
go back to reference Eckersten D, Giwercman A, Pihlsgard M, Bruun L, Christensson A (2018) Impact of kidney transplantation on reproductive hormone levels in males: a longitudinal study. Nephron 138:192–201CrossRefPubMed Eckersten D, Giwercman A, Pihlsgard M, Bruun L, Christensson A (2018) Impact of kidney transplantation on reproductive hormone levels in males: a longitudinal study. Nephron 138:192–201CrossRefPubMed
80.
go back to reference Eckersten D, Giwercman A, Bruun L, Cristensson A (2015) Anti-Mullerian hormone, a Sertoli cell-derived marker, is decreased in plasma of male patients in all stages of chronic kidney disease. Andrology 3:1160–1164CrossRefPubMed Eckersten D, Giwercman A, Bruun L, Cristensson A (2015) Anti-Mullerian hormone, a Sertoli cell-derived marker, is decreased in plasma of male patients in all stages of chronic kidney disease. Andrology 3:1160–1164CrossRefPubMed
81.
go back to reference Eckersten D, Giwercman A, Christensson A (2015) Male patients with terminal renal failure exhibit low serum levels of antimullerian hormone. Asian J Androl 17:149–153CrossRefPubMed Eckersten D, Giwercman A, Christensson A (2015) Male patients with terminal renal failure exhibit low serum levels of antimullerian hormone. Asian J Androl 17:149–153CrossRefPubMed
84.
go back to reference Hotaling JM, Patel Z (2014) Male endocrine dysfunction. Urol Clin N Am 41(1):39CrossRef Hotaling JM, Patel Z (2014) Male endocrine dysfunction. Urol Clin N Am 41(1):39CrossRef
85.
go back to reference Eckersten D, Tsatsanis C, Giwercman A, Bruun L, Pihlsgard M, Christensson A (2017) MicroRNA-155 and anti-Mullerian hormone: new potential markers of subfertility in men with chronic kidney disease. Nephron Extra 7:33–41CrossRefPubMedPubMedCentral Eckersten D, Tsatsanis C, Giwercman A, Bruun L, Pihlsgard M, Christensson A (2017) MicroRNA-155 and anti-Mullerian hormone: new potential markers of subfertility in men with chronic kidney disease. Nephron Extra 7:33–41CrossRefPubMedPubMedCentral
86.
go back to reference Fryckstedt J, Hylander B (2008) Sexual function in patients with end-stage renal disease. Scand J Urol Nephrol 42:466–471CrossRefPubMed Fryckstedt J, Hylander B (2008) Sexual function in patients with end-stage renal disease. Scand J Urol Nephrol 42:466–471CrossRefPubMed
87.
go back to reference Tanio J, Jahnukainen K, Nurmio M, Pakarinen M, Jalanko H, Jahnukainen T (2014) Testicular function, semen quality, and fertility in young men after renal transplantation during childhood or adolescence. Transplantation 98(9):987–993CrossRef Tanio J, Jahnukainen K, Nurmio M, Pakarinen M, Jalanko H, Jahnukainen T (2014) Testicular function, semen quality, and fertility in young men after renal transplantation during childhood or adolescence. Transplantation 98(9):987–993CrossRef
88.
go back to reference Akbari F, Alavi M, Esteghamati A, Mehrsai A, Djaladat H, Zohrevand R et al (2003) Effect of renal transplantation on sperm quality and sex hormone levels. BJU Int 92(3):281–283CrossRefPubMed Akbari F, Alavi M, Esteghamati A, Mehrsai A, Djaladat H, Zohrevand R et al (2003) Effect of renal transplantation on sperm quality and sex hormone levels. BJU Int 92(3):281–283CrossRefPubMed
Metadata
Title
Fertility and reproductive care in chronic kidney disease
Authors
Sandra Marie Dumanski
Sofia Bano Ahmed
Publication date
01-02-2019
Publisher
Springer International Publishing
Published in
Journal of Nephrology / Issue 1/2019
Print ISSN: 1121-8428
Electronic ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-018-00569-9

Other articles of this Issue 1/2019

Journal of Nephrology 1/2019 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.