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Published in: Molecular Imaging and Biology 6/2009

01-11-2009 | Research Article

FDG-Accumulating Atherosclerotic Plaques Identified with 18F-FDG-PET/CT in 141 Patients

Authors: Johan A. Wassélius, Stig A. Larsson, Hans Jacobsson

Published in: Molecular Imaging and Biology | Issue 6/2009

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Abstract

Purpose

The aim of this study was to describe the prevalence of atherosclerotic plaques based on [18F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.

Procedures

One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.

Results

Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal aorta was the vessel with the highest plaque count. Patients with one risk factor had significantly less active and inactive plaques.

Conclusions

The observed association between the numbers of cardiovascular risk factors and the numbers of FDG-accumulating plaques as well as calcified plaques further supports the validity and value of FDG-PET/CT in the non-invasive identification and characterization of atherosclerotic disease.
Literature
2.
go back to reference Davies MJ (1996) Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation 94:2013–2020PubMed Davies MJ (1996) Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation 94:2013–2020PubMed
3.
go back to reference Fishbein MC, Siegel RJ (1996) How big are coronary atherosclerotic plaques that rupture? Circulation 94(10):2662–2666PubMed Fishbein MC, Siegel RJ (1996) How big are coronary atherosclerotic plaques that rupture? Circulation 94(10):2662–2666PubMed
4.
go back to reference Libby P (2006) Atherosclerosis: disease biology affecting the coronary vasculature. Am J Cardiol 98(12A):3Q–9QCrossRefPubMed Libby P (2006) Atherosclerosis: disease biology affecting the coronary vasculature. Am J Cardiol 98(12A):3Q–9QCrossRefPubMed
5.
go back to reference Bleeker-Rovers CP, Bredie SJ, van der Meer JW et al (2003) F-18-fluorodeoxyglucose positron emission tomography in diagnosis and follow-up of patients with different types of vasculitis. Neth J Med 61(10):323–329PubMed Bleeker-Rovers CP, Bredie SJ, van der Meer JW et al (2003) F-18-fluorodeoxyglucose positron emission tomography in diagnosis and follow-up of patients with different types of vasculitis. Neth J Med 61(10):323–329PubMed
6.
go back to reference Blockmans D, De Ceuninck L, Vanderschueren S et al (2007) Repetitive 18-fluorodeoxyglucose positron emission tomography in isolated polymyalgia rheumatica: a prospective study in 35 patients. Rheumatology (Oxford) 46(4):672–677CrossRef Blockmans D, De Ceuninck L, Vanderschueren S et al (2007) Repetitive 18-fluorodeoxyglucose positron emission tomography in isolated polymyalgia rheumatica: a prospective study in 35 patients. Rheumatology (Oxford) 46(4):672–677CrossRef
7.
go back to reference Lederman RJ, Raylman RR, Fisher SJ et al (2001) Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG). Nucl Med Commun 22(7):747–753CrossRefPubMed Lederman RJ, Raylman RR, Fisher SJ et al (2001) Detection of atherosclerosis using a novel positron-sensitive probe and 18-fluorodeoxyglucose (FDG). Nucl Med Commun 22(7):747–753CrossRefPubMed
8.
go back to reference Ogawa M, Ishino S, Mukai T et al (2004) (18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study. J Nucl Med 45(7):1245–1250PubMed Ogawa M, Ishino S, Mukai T et al (2004) (18)F-FDG accumulation in atherosclerotic plaques: immunohistochemical and PET imaging study. J Nucl Med 45(7):1245–1250PubMed
9.
go back to reference Rudd JH, Warburton EA, Fryer TD et al (2002) Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 105(23):2708–2711CrossRefPubMed Rudd JH, Warburton EA, Fryer TD et al (2002) Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 105(23):2708–2711CrossRefPubMed
10.
go back to reference Davies JR, Rudd JH, Fryer TD et al (2005) Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxy-glucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 36(12):2642–2647CrossRefPubMed Davies JR, Rudd JH, Fryer TD et al (2005) Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxy-glucose positron-emission tomography and high-resolution magnetic resonance imaging. Stroke 36(12):2642–2647CrossRefPubMed
11.
go back to reference Tawakol A, Migrino RQ, Bashian GG et al (2006) In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 48(9):1818–1824CrossRefPubMed Tawakol A, Migrino RQ, Bashian GG et al (2006) In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 48(9):1818–1824CrossRefPubMed
12.
go back to reference Tahara N, Kai H, Ishibashi M et al (2006) Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 48(9):1825–1831CrossRefPubMed Tahara N, Kai H, Ishibashi M et al (2006) Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 48(9):1825–1831CrossRefPubMed
13.
go back to reference Ben-Haim S, Kupzov E, Tamir A et al (2004) Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET/CT. J Nucl Med 45(11):1816–1821PubMed Ben-Haim S, Kupzov E, Tamir A et al (2004) Evaluation of 18F-FDG uptake and arterial wall calcifications using 18F-FDG PET/CT. J Nucl Med 45(11):1816–1821PubMed
14.
go back to reference Dunphy MP, Freiman A, Larson SM et al (2005) Association of vascular 18F-FDG uptake with vascular calcification. J Nucl Med 46(8):1278–1284PubMed Dunphy MP, Freiman A, Larson SM et al (2005) Association of vascular 18F-FDG uptake with vascular calcification. J Nucl Med 46(8):1278–1284PubMed
15.
go back to reference Tahara N, Kai H, Yamagishi S et al (2007) Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol 49(14):1533–1539CrossRefPubMed Tahara N, Kai H, Yamagishi S et al (2007) Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol 49(14):1533–1539CrossRefPubMed
Metadata
Title
FDG-Accumulating Atherosclerotic Plaques Identified with 18F-FDG-PET/CT in 141 Patients
Authors
Johan A. Wassélius
Stig A. Larsson
Hans Jacobsson
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Molecular Imaging and Biology / Issue 6/2009
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI
https://doi.org/10.1007/s11307-009-0223-2

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