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International Archives of Occupational and Environmental Health

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09-12-2023 | Fatty Liver | Original Article

Relationship between exposure to metalworking fluids and nonalcoholic fatty liver disease

Authors: Weiling Chan, Geyang Li, Li Zhou, Jin Wang, Lin Song, Lejia Zhu, Lan Lin, Beining Wu, Jing Xiao, Yulong Lian

Published in: International Archives of Occupational and Environmental Health | Issue 1/2024

Abstract

Objective

The relationship between metalworking fluids (MWFs) and nonalcoholic fatty liver disease (NAFLD) has not been previously explored. We aim to investigate the relationship between occupational exposure to MWFs and the prevalence of NAFLD and to determine the cumulative exposure threshold per day.

Methods

In 2020, 2079 employees were selected randomly from one computer numerical control machining factory in Wuxi for a questionnaire survey, and occupational health examinations were conducted at the affiliated branch of Wuxi Eighth People's Hospital. MWF samples were collected within the factory using the National Institute for Occupational Safety and Health (NIOSH) 5524 method. NAFLD was defined as having a hepatic steatosis index (HSI) ≥ 36 without significant alcohol consumption. The relationship between NAFLD and MWFs was analyzed using logistic regression, and the daily exposure threshold was calculated using R software.

Results

MWF exposure was found to be a risk factor for NAFLD in exposed workers compared to the non-exposed group. The OR for NAFLD in workers exposed to MWFs compared to controls was 1.42 (95% CI: 1.04–1.95). An increased risk of NAFLD was shown to be associated with an increasing dose. The daily exposure dose threshold to MWFs was found to be 6.54 mg/m³ (OR = 2.09, 95% CI: 1.24–3.52).

Conclusion

An association between occupational exposure to MWFs and NAFLD was found. As the concentration of exposure rose, the prevalence of NAFLD was also escalated.

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Title: Relationship between exposure to metalworking fluids and nonalcoholic fatty liver disease
Authors: Weiling Chan
Geyang Li
Li Zhou
Jin Wang
Lin Song
Lejia Zhu
Lan Lin
Beining Wu
Jing Xiao
Yulong Lian
Publication date: 09-12-2023
Publisher: Springer Berlin Heidelberg
Keyword: Fatty Liver
Published in: International Archives of Occupational and Environmental Health / Issue 1/2024
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI: https://doi.org/10.1007/s00420-023-02025-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between exposure to metalworking fluids and nonalcoholic fatty liver disease

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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