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Open Access 01-12-2021 | Fatty Liver | Research

Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey

Authors: Rui Huang, Jian-Gao Fan, Jun-Ping Shi, Yi-Min Mao, Bing-Yuan Wang, Jing-Min Zhao, Lun-Gen Lu, Bi-Hui Zhong, Zheng-Sheng Zou, You-Qing Xu, Yi-Nong Ye, Long-Gen Liu, Lian-Jie Lin, Jian-Ping Li, Hui-Ying Rao, Lai Wei

Published in: Health and Quality of Life Outcomes | Issue 1/2021

Abstract

Background

Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient’s health status, including physical, emotional, mental and social well-being. In this study, we aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on HRQL in a Chinese population.

Methods

In this national multicenter cross-sectional survey, patients with NAFLD were enrolled. Chronic Liver Disease Questionnaire (CLDQ)-NAFLD was used to qualify HRQL. Univariate and multivariate analysis were used to identify independent risk factors of HRQL.

Results

A total of 5181 patients with NAFLD from 90 centers were enrolled in this study (mean age, 43.8 ± 13.3 years; male, 65.8%). The overall CLDQ score was 5.66 ± 0.89. Multivariate logistic regression analysis showed that body mass index (BMI: HR, 1.642; 95% CI, 1.330–2.026), alanine transaminase (ALT: HR, 1.006; 95% CI, 1.001–1.011), triglyceride (HR, 1.184; 95% CI, 1.074–1.305), disease severity (HR, 3.203; 95% CI, 1.418–7.232) and cardiovascular disease (HR, 4.305; 95% CI, 2.074–8.939) were independent risk factors for overall CLDQ score. In the logistic analyses of individual domain, BMI and triglyceride were independent risk factors of all domains. ALT, disease severity, diabetes, depression and cardiovascular disease were influencing factors for the CLDQ score of several domains.

Conclusions

This national multicenter cross-sectional survey in China indicated that the HRQL in patients with NAFLD was impaired. HRQL was found to be significantly associated with sociodemographic and clinical factors. Attention should be paid to the optimally managing care of patients with NAFLD to improve their HRQL.

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Title: Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey
Authors: Rui Huang
Jian-Gao Fan
Jun-Ping Shi
Yi-Min Mao
Bing-Yuan Wang
Jing-Min Zhao
Lun-Gen Lu
Bi-Hui Zhong
Zheng-Sheng Zou
You-Qing Xu
Yi-Nong Ye
Long-Gen Liu
Lian-Jie Lin
Jian-Ping Li
Hui-Ying Rao
Lai Wei
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Fatty Liver
Published in: Health and Quality of Life Outcomes / Issue 1/2021
Electronic ISSN: 1477-7525
DOI: https://doi.org/10.1186/s12955-021-01778-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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