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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Fas deficiency attenuates bone loss during antigen induced arthritis in mice

Authors: Elvira Lazic Mosler, Sania Kuzmac, Sanja Ivcevic, Danka Grcevic, Ana Marusic, Natasa Kovacic

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Antigen induced arthritis (AIA) is an experimental model of rheumatoid arthritis induced by methylated bovine serum albumin (mBSA) [1]. Hyperplastic synovia in AIA contains fibroblast-like synoviocytes (FLS) with reduced ability to differentiate into osteoblasts, chondroblasts or adipocytes [2]. Since Fas is shown to inhibit osteoblast differentiation [3], we were interested whether such inhibitory effect may contribute to the pathogenesis of AIA. …
Literature
1.
van den Berg WB, et al: Murine antigen-induced arthritis. Methods in Molecular Medicine, Volume 136: Arthritis Research. 2007, Cope AP Totowa (NJ): Humana Press Inc, 2: 243-253.
2.
Li X, Makarov SS: An essential role of NF-kappaB in the "tumor-like" phenotype of arthritic synoviocytes. Proc Natl Acad Sci USA. 2006, 103: 17432-7. 10.1073/pnas.0607939103.PubMedCentralCrossRefPubMed
3.
Kovacic N, Lukic IK, Grcevic D, Katavic V, Croucher P, Marusic A: The Fas/Fas-ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis. J Immunol. 2007, 178: 3379-89.PubMedCentralCrossRefPubMed
Metadata
Title
Fas deficiency attenuates bone loss during antigen induced arthritis in mice
Authors
Elvira Lazic Mosler
Sania Kuzmac
Sanja Ivcevic
Danka Grcevic
Ana Marusic
Natasa Kovacic
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3639

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