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International Urogynecology Journal

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01-04-2021 | Review Article

Family history and pelvic organ prolapse: a systematic review and meta-analysis

Authors: Parisa Samimi, Sarah H. Jones, Ayush Giri

Published in: International Urogynecology Journal | Issue 4/2021

Abstract

Introduction and hypothesis

Numerous analytic observational studies assess family history as a risk factor for POP and report a wide range of associations. This review aims to systematically evaluate the role of family history of POP in relation to POP risk and its recurrence.

Methods

A review was performed of the PubMed/MEDLINE database with search criteria specifying family history, risk factors, POP, and their synonyms as title/abstract keywords, as well as MESH terms, up to March 2020. We aggregated evidence across studies with fixed effects (FE) and random effects (RE) meta-analysis.

Results

Forty-three articles underwent full-text review. Eighteen independent studies evaluating the relationship between family history of POP and POP risk in 3639 POP cases and 10,912 controls were eligible for meta-analysis. Four studies evaluating family history and POP recurrence in 224 recurrent cases and 400 non-recurrent cases were eligible for inclusion into another meta-analyses. A positive family history of POP is on average associated with 2.3- to 2.7-fold increased risk for POP (RE OR = 2.64; 95% CI = 2.07, 3.35) as well as a 1.4-fold increased risk for POP recurrence (FE OR = 1.44; 95% CI = 1.00, 2.08). Meta-analysis estimates of POP risk varied by study design, definition of family history, and model adjustment status. We found evidence that publication bias and recall bias are a possibility.

Conclusions

Family history of POP is a risk factor for both POP presence and recurrence. However, reported magnitudes may be overestimates due to confounding, recall bias, and publication bias.

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Title: Family history and pelvic organ prolapse: a systematic review and meta-analysis
Authors: Parisa Samimi
Sarah H. Jones
Ayush Giri
Publication date: 01-04-2021
Publisher: Springer International Publishing
Published in: International Urogynecology Journal / Issue 4/2021
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-020-04559-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Family history and pelvic organ prolapse: a systematic review and meta-analysis

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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