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International Urogynecology Journal

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Open Access 01-11-2015 | Review Article

Risk factors for pelvic organ prolapse and its recurrence: a systematic review

Authors: Tineke F. M. Vergeldt, Mirjam Weemhoff, Joanna IntHout, Kirsten B. Kluivers

Published in: International Urogynecology Journal | Issue 11/2015

Abstract

Introduction and hypothesis

Pelvic organ prolapse (POP) is a common condition with multifactorial etiology. The purpose of this systematic review was to provide an overview of literature on risk factors for POP and POP recurrence.

Methods

PubMed and Embase were searched with “pelvic organ prolapse” combined with “recurrence” and combined with “risk factors,” with Medical Subject Headings and Thesaurus terms and text words variations until 4 August 2014, without language or publication date restrictions. Only cohort or cross-sectional studies carried out in western developed countries containing multivariate analyses and with a definition of POP based on anatomical references were included. POP recurrence had to be defined as anatomical recurrence after native tissue repair without mesh. Follow-up after surgery should have been at least 1 year. Articles were excluded if POP was not a separate entity or if it was unclear whether the outcome was primary POP or recurrence.

Results

PubMed and Embase revealed 2,988 and 4,449 articles respectively. After preselection, 534 articles were independently evaluated by two researchers, of which 15 met the selection criteria. In 10 articles on primary POP, 30 risk factors were investigated. Parity, vaginal delivery, age, and body mass index (BMI) were significantly associated in at least two articles. In 5 articles on POP recurrence, 29 risk factors were investigated. Only preoperative stage was significantly associated in at least two articles.

Conclusion

Parity, vaginal delivery, age, and BMI are risk factors for POP and preoperative stage is a risk factor for POP recurrence.

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Title: Risk factors for pelvic organ prolapse and its recurrence: a systematic review
Authors: Tineke F. M. Vergeldt
Mirjam Weemhoff
Joanna IntHout
Kirsten B. Kluivers
Publication date: 01-11-2015
Publisher: Springer London
Published in: International Urogynecology Journal / Issue 11/2015
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-015-2695-8

At a glance: The STEP trials

Springer Medicine

Risk factors for pelvic organ prolapse and its recurrence: a systematic review

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

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