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Published in: BMC Gastroenterology 1/2015

Open Access 01-12-2015 | Research article

Factors impacting physicians’ decisions to prevent variceal hemorrhage

Authors: Kathleen Yan, John FP Bridges, Salvador Augustin, Loren Laine, Guadalupe Garcia-Tsao, Liana Fraenkel

Published in: BMC Gastroenterology | Issue 1/2015

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Abstract

Background

Reasons underlying the variability of physicians’ preferences for non-selective beta-blockers (BBs) and endoscopic variceal ligation (EVL) to prevent a first variceal bleed have not been empirically studied. Our aims were to examine whether 1) gastroenterologists can be classified into distinct subgroups based on how they prioritize specific treatment attributes and 2) physician characteristics are associated with treatment preference.

Methods

We surveyed physicians to determine their preferred treatment for a standardized patient with large varices and examined the influence of treatment characteristics on physicians’ decision making using best-worst scaling. Latent class analysis was used to examine whether physicians could be classified into groups with similar decision-making styles.

Results

110 physicians were interviewed (participation rate 39%). The majority spent two or more days a week performing endoscopies and had practices comprising less than 25% of patients with liver disease. Latent class analysis demonstrated that physicians could be classified into at least two distinct groups. Most (n = 80, Group 1) were influenced solely by the ability to visually confirm eradication of varices. In contrast, members of Group 2 (n = 30) were influenced by the side effects and mechanism of action of BBs. Group 1 members were more likely to have practices that included fewer patients with liver disease and more likely to choose options including EVL (p = 0.01 for both).

Conclusions

Among physicians, where the majority performs endoscopy on two or more days per week, most prefer prevention strategies which include EVL. This may be due to the strong appeal of being able to visualize eradication of varices.
Literature
1.
go back to reference Garcia-Tsao G, Groszmann RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology. 1985;5:419–24.CrossRefPubMed Garcia-Tsao G, Groszmann RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology. 1985;5:419–24.CrossRefPubMed
2.
go back to reference Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46:922–38.CrossRefPubMed Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology. 2007;46:922–38.CrossRefPubMed
3.
go back to reference D'Amico G, Pagliaro L, Bosch J. Pharmacological treatment of portal hypertension: an evidence-based approach. Sem Liv Dis. 1999;19:475–505.CrossRef D'Amico G, Pagliaro L, Bosch J. Pharmacological treatment of portal hypertension: an evidence-based approach. Sem Liv Dis. 1999;19:475–505.CrossRef
4.
go back to reference Villanueva C, Aracil C, Colomo A, Hernández-Gea V, López-Balaguer JM, Alvarez-Urturi C, et al. Acute hemodynamic response to beta-blockers and prediction of long-term outcome in primary prophylaxis of variceal bleeding. Gastroenterology. 2009;137:119–28.CrossRefPubMed Villanueva C, Aracil C, Colomo A, Hernández-Gea V, López-Balaguer JM, Alvarez-Urturi C, et al. Acute hemodynamic response to beta-blockers and prediction of long-term outcome in primary prophylaxis of variceal bleeding. Gastroenterology. 2009;137:119–28.CrossRefPubMed
5.
go back to reference Gluud LL, Krag A. Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults. Cochrane Database Syst Rev. 2012;8:CD004544.PubMed Gluud LL, Krag A. Banding ligation versus beta-blockers for primary prevention in oesophageal varices in adults. Cochrane Database Syst Rev. 2012;8:CD004544.PubMed
6.
go back to reference Bai M, Qi X, Yang M, Han G, Fan D. Combined therapies versus monotherapies for the first variceal bleeding in patients with high-risk varices: a meta-analysis of randomized controlled trials. J Gastroenterol Hepatol. 2014;29:442–52.CrossRefPubMed Bai M, Qi X, Yang M, Han G, Fan D. Combined therapies versus monotherapies for the first variceal bleeding in patients with high-risk varices: a meta-analysis of randomized controlled trials. J Gastroenterol Hepatol. 2014;29:442–52.CrossRefPubMed
7.
go back to reference de Franchis R. Endoscopy critics vs. endoscopy enthusiasts for primary prophylaxis of variceal bleeding. Hepatology. 2006;43:24–6.CrossRefPubMed de Franchis R. Endoscopy critics vs. endoscopy enthusiasts for primary prophylaxis of variceal bleeding. Hepatology. 2006;43:24–6.CrossRefPubMed
8.
go back to reference Jensen DM. Outcomes, effectiveness, tolerability, and direct costs of prophylactic variceal treatments. Hepatology. 2006;43:197–8.CrossRef Jensen DM. Outcomes, effectiveness, tolerability, and direct costs of prophylactic variceal treatments. Hepatology. 2006;43:197–8.CrossRef
9.
go back to reference Longacre AV, Imaeda A, Garcia-Tsao G, Fraenkel L. A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage. Hepatology. 2008;47:169–76.CrossRefPubMedPubMedCentral Longacre AV, Imaeda A, Garcia-Tsao G, Fraenkel L. A pilot project examining the predicted preferences of patients and physicians in the primary prophylaxis of variceal hemorrhage. Hepatology. 2008;47:169–76.CrossRefPubMedPubMedCentral
10.
go back to reference Finn A, Louviere JJ. Determining the appropriate response to evidence of public concern: the case of food safety. J Public Policy Marketing. 1992;11:12–25. Finn A, Louviere JJ. Determining the appropriate response to evidence of public concern: the case of food safety. J Public Policy Marketing. 1992;11:12–25.
11.
go back to reference Bridges JF, Joy S, Gallego G, Blauvelt BM, Geschwind JF, Pawlik T. Priorities for hepatocellular carcinoma (HCC) control: a comparison of policy needs in five European countries. J Comp Pol Anal. 2012;14:352–68. Bridges JF, Joy S, Gallego G, Blauvelt BM, Geschwind JF, Pawlik T. Priorities for hepatocellular carcinoma (HCC) control: a comparison of policy needs in five European countries. J Comp Pol Anal. 2012;14:352–68.
12.
13.
go back to reference Najafzadeh M, Lynd LD, Davis JC, Bryan S, Anis A, Marra M, et al. Barriers to integrating personalized medicine into clinical practice: a best-worst scaling choice experiment. Genet Med. 2012;14:520–6.CrossRefPubMed Najafzadeh M, Lynd LD, Davis JC, Bryan S, Anis A, Marra M, et al. Barriers to integrating personalized medicine into clinical practice: a best-worst scaling choice experiment. Genet Med. 2012;14:520–6.CrossRefPubMed
14.
go back to reference Ratcliffe J, Flynn T, Terlich F, Stevens K, Brazier J, Sawyer M. Developing adolescent-specific health state values for economic evaluation: an application of profile case best-worst scaling to the Child Health Utility 9D. PharmacoEconomics. 2012;30:713–27.CrossRefPubMed Ratcliffe J, Flynn T, Terlich F, Stevens K, Brazier J, Sawyer M. Developing adolescent-specific health state values for economic evaluation: an application of profile case best-worst scaling to the Child Health Utility 9D. PharmacoEconomics. 2012;30:713–27.CrossRefPubMed
15.
go back to reference Youden WJ. Use of incomplete block replications in estimating tobacco-mosaic virus: contributions. Boyce Thompson Inst Plant Res. 1937;8:41–8. Youden WJ. Use of incomplete block replications in estimating tobacco-mosaic virus: contributions. Boyce Thompson Inst Plant Res. 1937;8:41–8.
16.
go back to reference Youden WJ. Experimental designs to increase accuracy of greenhouse studies: contributions. Boyce Thompson Inst Plant Res. 1940;11:219–28. Youden WJ. Experimental designs to increase accuracy of greenhouse studies: contributions. Boyce Thompson Inst Plant Res. 1940;11:219–28.
17.
18.
go back to reference de Franchis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53:762–8.CrossRefPubMed de Franchis R. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53:762–8.CrossRefPubMed
19.
go back to reference Thiele M, Krag A, Rohde U, Gluud LL. Meta-analysis: banding ligation and medical interventions for the prevention of rebleeding from oesophageal varices. Aliment Pharmacol Ther. 2012;35:1155–65.CrossRefPubMed Thiele M, Krag A, Rohde U, Gluud LL. Meta-analysis: banding ligation and medical interventions for the prevention of rebleeding from oesophageal varices. Aliment Pharmacol Ther. 2012;35:1155–65.CrossRefPubMed
20.
go back to reference Lugtenberg M, Burgers JS, Besters CF, Han D, Westert GP. Perceived barriers to guideline adherence: a survey among general practitioners. BMC Fam Pract. 2011;12:98.CrossRefPubMedPubMedCentral Lugtenberg M, Burgers JS, Besters CF, Han D, Westert GP. Perceived barriers to guideline adherence: a survey among general practitioners. BMC Fam Pract. 2011;12:98.CrossRefPubMedPubMedCentral
21.
go back to reference Lugtenberg M, Zegers-van Schaick JM, Westert GP, Burgers JS. Why don't physicians adhere to guideline recommendations in practice? An analysis of barriers among Dutch general practitioners. Implement Sci. 2009;4:54.CrossRefPubMedPubMedCentral Lugtenberg M, Zegers-van Schaick JM, Westert GP, Burgers JS. Why don't physicians adhere to guideline recommendations in practice? An analysis of barriers among Dutch general practitioners. Implement Sci. 2009;4:54.CrossRefPubMedPubMedCentral
23.
go back to reference Trout JD. The psychology of scientific explanation. Philosophy Compass. 2007;2:564–91.CrossRef Trout JD. The psychology of scientific explanation. Philosophy Compass. 2007;2:564–91.CrossRef
24.
go back to reference Flynn TN. Valuing citizen and patient preferences in health: recent developments in three types of best-worst scaling. Expert Rev Pharmacoecon Outcomes Res. 2010;10:259–67.CrossRefPubMed Flynn TN. Valuing citizen and patient preferences in health: recent developments in three types of best-worst scaling. Expert Rev Pharmacoecon Outcomes Res. 2010;10:259–67.CrossRefPubMed
25.
go back to reference Flynn TN, Louviere JJ, Peters TJ, Coast J. Best-worst scaling: what it can do for health care research and how to do it. J Health Econ. 2007;26:171–89.CrossRefPubMed Flynn TN, Louviere JJ, Peters TJ, Coast J. Best-worst scaling: what it can do for health care research and how to do it. J Health Econ. 2007;26:171–89.CrossRefPubMed
26.
go back to reference Gallego G, Bridges JF, Flynn T, Blauvelt BM, Niessen LW. Using best-worst scaling in horizon scanning for hepatocellular carcinoma technologies. Int J Technol Assess Health Care. 2012;28:339–46.CrossRefPubMed Gallego G, Bridges JF, Flynn T, Blauvelt BM, Niessen LW. Using best-worst scaling in horizon scanning for hepatocellular carcinoma technologies. Int J Technol Assess Health Care. 2012;28:339–46.CrossRefPubMed
27.
go back to reference Louviere JJ, Flynn TN. Using best-worst scaling choice experiments to measure public perceptions and preferences for healthcare reform in Australia. Patient. 2010;3:275–83.CrossRefPubMed Louviere JJ, Flynn TN. Using best-worst scaling choice experiments to measure public perceptions and preferences for healthcare reform in Australia. Patient. 2010;3:275–83.CrossRefPubMed
Metadata
Title
Factors impacting physicians’ decisions to prevent variceal hemorrhage
Authors
Kathleen Yan
John FP Bridges
Salvador Augustin
Loren Laine
Guadalupe Garcia-Tsao
Liana Fraenkel
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Gastroenterology / Issue 1/2015
Electronic ISSN: 1471-230X
DOI
https://doi.org/10.1186/s12876-015-0287-1

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