Published in:
01-08-2005 | Original Paper
Extraskeletal osteosarcoma has a favourable prognosis when treated like conventional osteosarcoma
Authors:
Sing Yu Goldstein-Jackson, Georg Gosheger, Günter Delling, Wolfgang E. Berdel, G. Ulrich. Exner, Gernot Jundt, Jan-Nicolas Machatschek, Andreas Zoubek, Heribert Jürgens, Stefan S. Bielack, for the Cooperative Osteosarcoma Study Group COSS
Published in:
Journal of Cancer Research and Clinical Oncology
|
Issue 8/2005
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Abstract
Purpose: The aims of this analysis were to investigate the clinical features of extraskeletal osteosarcoma (ESOS) and examine the outcome after multi-modal therapy. Methods: The co-operative osteosarcoma study-group database was searched for patients with extraskeletal osteosarcoma. Eligible patients were included in a retrospective analysis of patient, tumour and treatment related variables and outcome. As for conventional osteosarcoma, scheduled treatment included surgery and multi-agent chemotherapy. Results: Seventeen eligible patients were identified with a median age of 44 years (range, 3–65 years). The thigh was the commonest tumour site. Two patients had a history of previous malignancies and two had primary metastases. Median follow-up was 3.2 years (range: 0.6–7.4 years) and at last follow-up, 11 patients were alive in complete remission, 3 patients were alive with disease and 3 patients had died of their disease. Three-year overall actuarial and event-free survival rates were 77% and 56%, respectively. Patients with macroscopically complete surgical remission had an improved overall survival (P=0.0004). Conclusions: The patients in this retrospective study had a surprisingly good survival rate. This may be due to the combination of multi-agent chemotherapy with surgery, and we recommend this approach in the treatment of ESOS.