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World Journal of Surgical Oncology

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Open Access 01-12-2013 | Research

Extracorporeal tumor cell filtration during extended liver surgery: first clinical use of leukocyte depletion filters – a case series

Authors: Karl J. Oldhafer, Gregor A. Stavrou, Marcello Donati, Philipp Kaudel, Nils R. Frühauf

Published in: World Journal of Surgical Oncology | Issue 1/2013

Abstract

Background

During oncologic surgery, intraoperative manipulation of tumor tissue is almost unpreventable and causes a high risk of tumor cell dissemination into venous blood. A tumor cell-reducing effect of leukocyte adhesion filter systems has been shown under in vitro conditions.

Methods

In a first clinical attempt, leukocyte adhesion filters were integrated into veno-venous bypass systems in four patients undergoing extended liver surgery for secondary hepatic malignancies.

Practicability, handling, and safety aspects as well as potency of cell removal and clinical side effects of the filter system were analyzed.

Results

All patients tolerated the application of the system without problems during operative and postoperative follow-up. Immunohistochemical staining of perioperative blood samples detected cytokeratin positive (CK+) cells in three cases during the hepatic mobilization.

Conclusions

Effectiveness of CK+ cell depletion and safety of the procedure was shown. The presented surgical technique represents a safe and innovative tool; however, clinical significance has to be examined in a larger patient cohort.

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Title: Extracorporeal tumor cell filtration during extended liver surgery: first clinical use of leukocyte depletion filters – a case series
Authors: Karl J. Oldhafer
Gregor A. Stavrou
Marcello Donati
Philipp Kaudel
Nils R. Frühauf
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: World Journal of Surgical Oncology / Issue 1/2013
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/1477-7819-11-159

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Extracorporeal tumor cell filtration during extended liver surgery: first clinical use of leukocyte depletion filters – a case series

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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