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Open Access 01-12-2015 | Case report

Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified?

Authors: Vittorio Branchi, Philipp Lingohr, Winfried A Willinek, Alexander Semaan, Hui Zhou, Glen Kristiansen, Günter Klöppel, Jörg C Kalff, Nico Schäfer, Hanno Matthaei

Published in: European Journal of Medical Research | Issue 1/2015

Abstract

Background

Cystic lesions of the pancreas resembling intraductal papillary mucinous neoplasms (IPMN) have been reported to develop in an increased rate following liver transplantation and immunosuppression. The cause for this possible association is thus far elusive.

Presentation of the case

We report on a 60-year-old male patient who developed an extensive multicystic change of the entire pancreas, suspicious for IPMN, under follow-up after liver transplantation for secondary sclerosing cholangitis. A total pancreaduodenectomy with splenectomy was performed. The postoperative histopathological assessment revealed a multifocal branch duct IPMN of the gastric subtype showing low-grade dysplasia.

Discussion

In the absence of evidence-based guidelines for the management of suspected IPMNs in liver transplant recipients, each patient’s management should be discussed in detail.

Conclusion

Prospective studies may help to understand the disease and identify risk factors for malignant transformation in IPMNs after liver transplantation for treatment optimization.

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Title: Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified?
Authors: Vittorio Branchi
Philipp Lingohr
Winfried A Willinek
Alexander Semaan
Hui Zhou
Glen Kristiansen
Günter Klöppel
Jörg C Kalff
Nico Schäfer
Hanno Matthaei
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2015
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-015-0117-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Extensive multifocal branch duct IPMN of the pancreas after liver transplantation: is surgery justified?

Abstract

Background

Presentation of the case

Discussion

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Presentation of the case

Discussion

Conclusion

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