Published in:
01-04-2006 | Erratum
Exserohilum: an emerging human pathogen
Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 4/2006
Login to get accessExcerpt
Due to a typesetting error, the last column was omitted from Tables 1 and 2.
Table 1
Characteristics of patients with invasive Exserohilum infection
|
Patient no. [ref.]
|
Age (y)/sex
|
Exserohilum species
|
Country/year of report
|
Underlying disease and predisposing factors
|
Sites of infection
|
Therapy (antifungal susceptibility; duration)
|
Outcome
|
|---|---|---|---|---|---|---|---|
|
1 [5]
|
12/M
|
rostratum a
|
Western USA/1980
|
None
|
Bone
|
Surgery, local and systemic AmBc
|
Cure
|
|
2 [6]
|
20/F
|
longirostratum b
|
France/1983
|
Surgical correction of congenital VSD and AI
|
Endocarditis, vertebral osteomyelitis
|
AmB, keto (72 h MFC=1 μg/ml for both; 10 months), surgery
|
Cure
|
|
3 [7]
|
63/M
|
rostratum
|
Israel/1987
|
AML; antimicrobial and chemotherapy; neutropenia
|
Skin (cutaneous), nasal mucosa
|
AmB (2 months)
|
Cure
|
|
4 [8]
|
5/F
|
rostratum
|
Texas, USA/1990
|
Aplastic anemia; cytotoxic therapy
|
Paranasal sinuses, soft tissue
|
AmB (48 h MIC<0.14 μg/ml), itra (48 h MIC<0.02 μg/ml)
|
Progression; death due to bacterial sepsis
|
|
5 [9]
|
16/M
|
NR
|
South Africa/1993
|
None
|
Skin (subcutaneous), lung, brain
|
AmB (total dose 2.5 g), 5-flu
|
Cure
|
|
6 [10]
|
7/F
|
rostratum
|
Texas, USA/1994
|
Aplastic anemia
|
Paranasal sinuses, lungs
|
AmB
|
Death
|
|
7 [11]
|
41/F
|
NR
|
Israel/2004
|
AML
|
Paranasal sinuses, lungs
|
AmB, itra
|
Failure; death due to bacterial sepsis
|
|
8 [12]
|
8/M
|
NR
|
Israel/2003
|
ALL, antimicrobial and chemotherapy; neutropenia
|
Skin (cutaneous), Paranasal sinuses, lungs
|
AmB, itra (5 mos.)
|
Cure; death due to malignancy and Fusarium infection
|
|
9 [PR]
|
8/F
|
NR
|
Israel/2005
|
ALL; antimicrobial and chemotherapy; neutropenia
|
Paranasal sinuses, lungs
|
AmB, vori (9 months), surgery
|
Cure
|
|
10 [PR]
|
3/F
|
NR
|
Israel/2005
|
ALL; antimicrobial and chemotherapy; neutropenia
|
Paranasal sinuses, soft palate
|
AmB, itra (13 months), surgery
|
Cure
|
Table 2
Characteristics of patients with Exserohilum skin and corneal infections
|
Patient no. [ref.]
|
Age (y)/sex
|
Exserohilum species
|
Country/year of report
|
Underlying diseases and predisposing factors
|
Sites of infection
|
Therapy (antifungal susceptibility; duration)
|
Outcome
|
|---|---|---|---|---|---|---|---|
|
11 [3]
|
34/F
|
rostratum
|
Calif., USA/1986
|
Cardiac transplantation; immunosuppression
|
Skin (subcutaneous)
|
AmB, keto, surgery
|
Cure
|
|
12 [13]
|
55/F
|
rostratum
|
S. Carolina, USA/1987
|
Fish sting
|
Skin (subcutaneous)
|
Surgery, keto (6 weeks)
|
Cure
|
|
13 [14]
|
3/M
|
rostratum
|
Tenn., USA/1991
|
ALL; antimicrobial and chemotherapy; neutropenia; local cloth tape
|
Skin (cutaneous)
|
AmB (24 h MIC=0.39 μg/ml; 1 month), 5-flu (24 h MIC >20 μg/ml; 2 weeks)
|
Cure
|
|
14 [15]
|
74/M
|
rostratum
|
Texas, USA/1991
|
COPD; steroid therapy
|
Skin (cutaneous)
|
Keto+topical clotrimazole (6 weeks)
|
Cure
|
|
15 [16]
|
63/M
|
rostratum
|
Taiwan/1993
|
Diabetes; local trauma
|
Skin (subcutaneous)
|
Keto (3 weeks)
|
No improvement; death due to bacterial sepsis
|
|
16 [16]
|
31/M
|
rostratum
|
Taiwan/1993
|
Topical steroids for psoriasis
|
Skin (cutaneous)
|
Topical bifonazole (2 weeks)
|
Cure
|
|
17 [17]
|
22/M
|
rostratum
|
Va., USA/1993
|
Superficial lacerations; cocaine use, MOF
|
Skin (cutaneous)
|
AmB
|
Death due to MOF
|
|
18 [18]
|
40/F
|
rostratum
|
India/1995
|
None
|
Skin (cutaneous)
|
None
|
Unknown
|
|
19 [19]
|
NR/NR
|
rostratum a
|
Fla., USA/1975
|
None
|
Cornea
|
Topical gentamicin
|
Cure
|
|
20 [20]
|
40/F
|
rostratum
|
India/1991
|
Rt. eye injury from a paddy leaf
|
Cornea
|
Topical keto
|
No improvement
|
|
21 [21]
|
47/M
|
longirostratum
|
Honduras/1994
|
Left eye struck by unknown foreign body during train riding
|
Cornea and uvea
|
Surgery, keto
|
Cure following enucleation
|
|
22 [22]
|
55/M
|
rostratum
|
India/1996
|
Lash injury to rt. eye by cow’s tail
|
Cornea
|
Topical nata + mico (6 weeks)
|
Cure (vision 6/18)
|
|
23 [23]
|
42/M
|
rostratum
|
India/1999
|
None
|
Cornea
|
Surgery, topical keto+nata
|
Cure (vision 6/18)
|
|
24 [24]
|
18/F
|
rostratum
|
India/2004
|
None
|
Cornea
|
topical itra
|
Cure
|