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Tumor Biology
Published in: Tumor Biology 9/2015

01-09-2015 | Research Article

Expression of myeloid zinc finger 1 and the correlation to clinical aspects of oral squamous cell carcinoma

Authors: Chung-Po Ko, Li-Chiu Yang, Chih-Jung Chen, Kun-Tu Yeh, Shu-Hui Lin, Shun-Fa Yang, Mu-Kuan Chen, Chiao-Wen Lin

Published in: Tumor Biology | Issue 9/2015

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Abstract

The myeloid zinc finger 1 (MZF1) is a zinc finger transcription factor which regulates myeloid differentiation and oncogenesis. However, little information is available concerning the MZF1 expression in oral squamous cell carcinoma (OSCC) and its correlation with patients’ prognosis. We detected the expression of MZF1 in 274 patients with OSCC using tissue microarrays (TMAs) and evaluated the associations between nuclear MZF1 expression and the clinical parameters of OSCC patients. We found that nuclear MZF1 expression was present in 190/274 (69.3 %) cases, and loss of nuclear expression of MZF1 was associated with more advanced clinical stages (p = 0.011) and larger tumor size (p = 0.002), but not associated with positive lymph node metastasis and distal metastasis. Importantly, tongue squamous cell carcinomas (SCC) patients with negative nuclear MZF1 expression had significantly worse overall survival rates (log-rank test, p = 0.028). In conclusion, our results revealed that the loss of nuclear expression of MZF1 in OSCC samples can predict the progression of OSCC and the survival of OSCC patients in Taiwan.
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Metadata
Title
Expression of myeloid zinc finger 1 and the correlation to clinical aspects of oral squamous cell carcinoma
Authors
Chung-Po Ko
Li-Chiu Yang
Chih-Jung Chen
Kun-Tu Yeh
Shu-Hui Lin
Shun-Fa Yang
Mu-Kuan Chen
Chiao-Wen Lin
Publication date
01-09-2015
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 9/2015
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3419-x

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